論文

国際誌
2019年7月1日

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism.

Brain : a journal of neurology
  • Keiho Owada
  • ,
  • Takashi Okada
  • ,
  • Toshio Munesue
  • ,
  • Miho Kuroda
  • ,
  • Toru Fujioka
  • ,
  • Yota Uno
  • ,
  • Kaori Matsumoto
  • ,
  • Hitoshi Kuwabara
  • ,
  • Daisuke Mori
  • ,
  • Yuko Okamoto
  • ,
  • Yuko Yoshimura
  • ,
  • Yuki Kawakubo
  • ,
  • Yuko Arioka
  • ,
  • Masaki Kojima
  • ,
  • Teruko Yuhi
  • ,
  • Walid Yassin
  • ,
  • Itaru Kushima
  • ,
  • Seico Benner
  • ,
  • Nanayo Ogawa
  • ,
  • Naoko Kawano
  • ,
  • Yosuke Eriguchi
  • ,
  • Yukari Uemura
  • ,
  • Maeri Yamamoto
  • ,
  • Yukiko Kano
  • ,
  • Kiyoto Kasai
  • ,
  • Haruhiro Higashida
  • ,
  • Norio Ozaki
  • ,
  • Hirotaka Kosaka
  • ,
  • Hidenori Yamasue

142
7
開始ページ
2127
終了ページ
2136
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/brain/awz126

Discrepancies in efficacy between single-dose and repeated administration of oxytocin for autism spectrum disorder have led researchers to hypothesize that time-course changes in efficacy are induced by repeated administrations of the peptide hormone. However, repeatable, objective, and quantitative measurement of autism spectrum disorder's core symptoms are lacking, making it difficult to examine potential time-course changes in efficacy. We tested this hypothesis using repeatable, objective, and quantitative measurement of the core symptoms of autism spectrum disorder. We examined videos recorded during semi-structured social interaction administered as the primary outcome in single-site exploratory (n = 18, crossover within-subjects design) and multisite confirmatory (n = 106, parallel-group design), double-blind, placebo-controlled 6-week trials of repeated intranasal administrations of oxytocin (48 IU/day) in adult males with autism spectrum disorder. The main outcomes were statistical representative values of objectively quantified facial expression intensity in a repeatable part of the Autism Diagnostic Observation Schedule: the maximum probability (i.e. mode) and the natural logarithm of mode on the probability density function of neutral facial expression and the natural logarithm of mode on the probability density function of happy expression. Our recent study revealed that increases in these indices characterize autistic facial expression, compared with neurotypical individuals. The current results revealed that oxytocin consistently and significantly decreased the increased natural logarithm of mode on the probability density function of neutral facial expression compared with placebo in exploratory (effect-size, -0.57; 95% CI, -1.27 to 0.13; P = 0.023) and confirmatory trials (-0.41; -0.62 to -0.20; P < 0.001). A significant interaction between time-course (at baseline, 2, 4, 6, and 8 weeks) and the efficacy of oxytocin on the natural logarithm of mode on the probability density function of neutral facial expression was found in confirmatory trial (P < 0.001). Post hoc analyses revealed maximum efficacy at 2 weeks (P < 0.001, Cohen's d = -0.78; 95% CI, -1.21 to -0.35) and deterioration of efficacy at 4 weeks (P = 0.042, Cohen's d = -0.46; 95% CI, -0.90 to -0.01) and 6 weeks (P = 0.10, Cohen's d = -0.35; 95% CI, -0.77 to 0.08), while efficacy was preserved at 2 weeks post-treatment (i.e. 8 weeks) (P < 0.001, Cohen's d = -1.24; 95% CI, -1.71 to -0.78). Quantitative facial expression analyses successfully verified the positive effects of repeated oxytocin on autistic individuals' facial expressions and demonstrated a time-course change in efficacy. The current findings support further development of an optimized regimen of oxytocin treatment.

リンク情報
DOI
https://doi.org/10.1093/brain/awz126
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31096266
ID情報
  • DOI : 10.1093/brain/awz126
  • ISSN : 0006-8950
  • PubMed ID : 31096266

エクスポート
BibTeX RIS