論文

国際誌
2021年

Influence of oxytocin administration on somatosensory evoked magnetic fields induced by median nerve stimulation during hand action observation in healthy male volunteers.

PloS one
  • Yasuki Ono
  • ,
  • Tetsu Hirosawa
  • ,
  • Chiaki Hasegawa
  • ,
  • Takashi Ikeda
  • ,
  • Kiwamu Kudo
  • ,
  • Nobushige Naito
  • ,
  • Yuko Yoshimura
  • ,
  • Mitsuru Kikuchi

16
3
開始ページ
e0249167
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0249167

Watching another person's hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalography (MEG) to investigate SEFs following electrical stimulation of the right median nerve in 20 healthy male participants during hand movement observation, which were initially presented as static images followed by moving images. The participants were randomly assigned to receive either oxytocin or saline during the first trial, with the treatment being reversed during a second trial. Log-transformed ratios of the N20 and N30 amplitudes were calculated and compared between moving and static images observations. Phase locking (calculated using intertrial phase coherence) of brain oscillations was also analyzed to evaluate alpha, beta and gamma rhythm changes after oxytocin administration. Log N30 ratios showed no significant changes after placebo administration but showed a decreasing tendency (albeit not significant) after placebo administration, which may suggest mirror neuron system involvement. In contrast, log N20 ratios were increased after placebo administration, but showed no significant change after oxytocin administration. Interestingly, the gamma band activity around N20 increased after placebo administration, suggesting that oxytocin exerted an analgesic effect on median nerve stimulation, and inhibited the gamma band increase. Oxytocin might therefore modulate not only the mirror neuron system, but also the sensory processing associated with median nerve stimulation.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0249167
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33788881
ID情報
  • DOI : 10.1371/journal.pone.0249167
  • PubMed ID : 33788881

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