論文

査読有り 国際誌
2021年7月

Physical and biological beam modeling for carbon beam scanning at Osaka Heavy Ion Therapy Center.

Journal of applied clinical medical physics
  • Shinichiro Fujitaka
  • Yusuke Fujii
  • Hideaki Nihongi
  • Satoshi Nakayama
  • Masaaki Takashina
  • Noriaki Hamatani
  • Toshiro Tsubouchi
  • Masashi Yagi
  • Kazumasa Minami
  • Kazuhiko Ogawa
  • Junetsu Mizoe
  • Tatsuaki Kanai
  • 全て表示

22
7
開始ページ
77
終了ページ
92
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/acm2.13262

We have developed physical and biological beam modeling for carbon scanning therapy at the Osaka Heavy Ion Therapy Center (Osaka HIMAK). Carbon beam scanning irradiation is based on continuous carbon beam scanning, which adopts hybrid energy changes using both accelerator energy changes and binary range shifters in the nozzles. The physical dose calculation is based on a triple Gaussian pencil-beam algorithm, and we thus developed a beam modeling method using dose measurements and Monte Carlo simulation for the triple Gaussian. We exploited a biological model based on a conventional linear-quadratic (LQ) model and the photon equivalent dose, without considering the dose dependency of the relative biological effectiveness (RBE), to fully comply with the carbon passive dose distribution using a ridge filter. We extended a passive ridge-filter design method, in which carbon and helium LQ parameters are applied to carbon and fragment isotopes, respectively, to carbon scanning treatment. We then obtained radiation quality data, such as the linear energy transfer (LET) and LQ parameters, by Monte Carlo simulation. The physical dose was verified to agree with measurements to within ±2% for various patterns of volume irradiation. Furthermore, the RBE in the middle of a spread-out Bragg peak (SOBP) reproduced that from passive dose distribution results to within ±1.5%. The developed carbon beam modeling and dose calculation program was successfully applied in clinical use at Osaka HIMAK.

リンク情報
DOI
https://doi.org/10.1002/acm2.13262
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33998157
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292693
ID情報
  • DOI : 10.1002/acm2.13262
  • PubMed ID : 33998157
  • PubMed Central 記事ID : PMC8292693

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