論文

査読有り 国際誌
2016年9月

Single-neuron and genetic correlates of autistic behavior in macaque

SCIENCE ADVANCES
  • Kyoko Yoshida
  • ,
  • Yasuhiro Go
  • ,
  • Itaru Kushima
  • ,
  • Atsushi Toyoda
  • ,
  • Asao Fujiyama
  • ,
  • Hiroo Imai
  • ,
  • Nobuhito Saito
  • ,
  • Atsushi Iriki
  • ,
  • Norio Ozaki
  • ,
  • Masaki Isoda

2
9
開始ページ
e1600558
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/sciadv.1600558
出版者・発行元
AMER ASSOC ADVANCEMENT SCIENCE

Atypical neurodevelopment in autism spectrum disorder is a mystery, defying explanation despite increasing attention. We report on a Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well as restricted and repetitive behaviors, along with our single-neuron and genomic analyses. Its social ability was measured in a turn-taking task, where two monkeys monitor each other's actions for adaptive behavioral planning. In its brain, the medial frontal neurons responding to others' actions, abundant in the controls, were almost nonexistent. In its genes, whole-exome sequencing and copy number variation analyses identified rare coding variants linked to human neuropsychiatric disorders in 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) and adenosine triphosphate (ATP)-binding cassette subfamily A13 (ABCA13). This combination of systems neuroscience and cognitive genomics in macaques suggests a new, phenotype-to-genotype approach to studying mental disorders.

リンク情報
DOI
https://doi.org/10.1126/sciadv.1600558
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27679817
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031467
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000383734400012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1126/sciadv.1600558
  • ISSN : 2375-2548
  • eISSN : 2375-2548
  • PubMed ID : 27679817
  • PubMed Central 記事ID : PMC5031467
  • Web of Science ID : WOS:000383734400012

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