2016年9月
Single-neuron and genetic correlates of autistic behavior in macaque
SCIENCE ADVANCES
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- 巻
- 2
- 号
- 9
- 開始ページ
- e1600558
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/sciadv.1600558
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Atypical neurodevelopment in autism spectrum disorder is a mystery, defying explanation despite increasing attention. We report on a Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well as restricted and repetitive behaviors, along with our single-neuron and genomic analyses. Its social ability was measured in a turn-taking task, where two monkeys monitor each other's actions for adaptive behavioral planning. In its brain, the medial frontal neurons responding to others' actions, abundant in the controls, were almost nonexistent. In its genes, whole-exome sequencing and copy number variation analyses identified rare coding variants linked to human neuropsychiatric disorders in 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) and adenosine triphosphate (ATP)-binding cassette subfamily A13 (ABCA13). This combination of systems neuroscience and cognitive genomics in macaques suggests a new, phenotype-to-genotype approach to studying mental disorders.
- リンク情報
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- DOI
- https://doi.org/10.1126/sciadv.1600558
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27679817
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031467
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000383734400012&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1126/sciadv.1600558
- ISSN : 2375-2548
- eISSN : 2375-2548
- PubMed ID : 27679817
- PubMed Central 記事ID : PMC5031467
- Web of Science ID : WOS:000383734400012