論文

国際誌
2021年9月

Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status.

Diabetes care
  • Mayuko Harada Yamada
  • ,
  • Kazuya Fujihara
  • ,
  • Satoru Kodama
  • ,
  • Takaaki Sato
  • ,
  • Taeko Osawa
  • ,
  • Yuta Yaguchi
  • ,
  • Masahiko Yamamoto
  • ,
  • Masaru Kitazawa
  • ,
  • Yasuhiro Matsubayashi
  • ,
  • Takaho Yamada
  • ,
  • Hiroyasu Seida
  • ,
  • Wataru Ogawa
  • ,
  • Hirohito Sone

44
9
開始ページ
2124
終了ページ
2131
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2337/dc20-2252

OBJECTIVE: To determine associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with new-onset coronary artery disease (CAD) or cerebrovascular disease (CVD) according to glucose status. RESEARCH DESIGN AND METHODS: Examined was a nationwide claims database from 2008 to 2016 on 593,196 individuals. A Cox proportional hazards model identified risks of CAD and CVD events among five levels of SBP and DBP. RESULTS: During the study period 2,240 CAD and 3,207 CVD events occurred. Compared with SBP ≤119 mmHg, which was the lowest quintile of SBP, hazard ratios (95% CI) for CAD/CVD in the 4 higher quintiles (120-129, 130-139, 140-149, ≥150 mmHg) gradually increased from 2.10 (1.73-2.56)/1.46 (1.27-1.68) in quintile 2 to 3.21 (2.37-4.34)/4.76 (3.94-5.75) in quintile 5 for normoglycemia, from 1.39 (1.14-1.69)/1.70 (1.44-2.01) in quintile 2 to 2.52 (1.95-3.26)/4.12 (3.38-5.02) in quintile 5 for borderline glycemia, and from 1.50 (1.19-1.90)/1.72 (1.31-2.26) in quintile 2 to 2.52 (1.95-3.26)/3.54 (2.66-4.70) in quintile 5 for diabetes. A similar trend was observed for DBP across 4 quintiles (75-79, 80-84, 85-89, and ≥90 mmHg) compared with ≥74 mmHg, which was the lowest quintile. CONCLUSIONS: Results indicated that cardiovascular risks gradually increased with increases in SBP and DBP regardless of the presence of and degree of a glucose abnormality. Further interventional trials are required to apply findings from this cohort study to clinical practice.

リンク情報
DOI
https://doi.org/10.2337/dc20-2252
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34035075
ID情報
  • DOI : 10.2337/dc20-2252
  • PubMed ID : 34035075

エクスポート
BibTeX RIS