論文

国際誌
2021年7月

Association of estimated plasma volume and weight loss after long-term administration and subsequent discontinuation of the sodium-glucose cotransporter-2 inhibitor tofogliflozin.

Diabetes, obesity & metabolism
  • Yasuhiro Matsubayashi
  • ,
  • Akihiro Yoshida
  • ,
  • Hideki Suganami
  • ,
  • Momoko Oe
  • ,
  • Takaaki Sato
  • ,
  • Yuta Yaguchi
  • ,
  • Kazuya Fujihara
  • ,
  • Takaho Yamada
  • ,
  • Shiro Tanaka
  • ,
  • Kohei Kaku
  • ,
  • Hirohito Sone

23
7
開始ページ
1660
終了ページ
1665
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/dom.14387

Sodium-glucose cotransporter-2 inhibitors (SGLT2) are drugs that have been reported to have several effects through the regulation of plasma volume, for example, antihypertensive effects. This study aimed to clarify the impact of long-term administration and subsequent discontinuation of the SGLT2 inhibitor tofogliflozin on estimated plasma volume (ePV), brain natriuretic peptide (BNP) and the relationship between changes in ePV, BNP and body weight (BW). Data from 157 participants with type 2 diabetes receiving tofogliflozin monotherapy in a phase 3 study were analysed. Changes in variables or correlations among them during a 52-week administration and a 2-week post-treatment period were investigated. Percent change in ePV was calculated using the Strauss formula. Significant decreases in BW, ePV and ln-transformed BNP (ln-BNP) were noted by week 52. %ΔBW was not significantly correlated with %ΔePV and Δln-BNP, while %ΔePV was significantly correlated with Δln-BNP. Two weeks after discontinuation of tofogliflozin, BW, ePV and ln-BNP were significantly increased. %ΔBW was significantly correlated with %ΔePV and Δln-BNP. Furthermore, ePV and BNP were significantly higher than baseline levels.

リンク情報
DOI
https://doi.org/10.1111/dom.14387
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33769665
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252731
ID情報
  • DOI : 10.1111/dom.14387
  • PubMed ID : 33769665
  • PubMed Central 記事ID : PMC8252731

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