2018年7月4日
Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury.
Scientific reports
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- 巻
- 8
- 号
- 1
- 開始ページ
- 10132
- 終了ページ
- 10132
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-018-28425-7
Neuritin is a small extracellular protein that plays important roles in the process of neural development, synaptic plasticity, and neural cell survival. Here we investigated the function of neuritin in a mouse model of optic nerve injury (ONI). ONI induced upregulation of neuritin mRNA in the retina of WT mice. The retinal structure and the number of retinal ganglion cells (RGCs) were normal in adult neuritin knockout (KO) mice. In vivo retinal imaging and histopathological analyses demonstrated that RGC death and inner retinal degeneration following ONI were more severe in neuritin KO mice. Immunoblot analyses revealed that ONI-induced phosphorylation of Akt and ERK were suppressed in neuritin KO mice. Our findings suggest that neuritin has neuroprotective effects following ONI and may be useful for treatment of posttraumatic complication.
- リンク情報
- ID情報
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- DOI : 10.1038/s41598-018-28425-7
- PubMed ID : 29973613
- PubMed Central 記事ID : PMC6031618