論文

筆頭著者 責任著者
2023年7月3日

WPOI-4/5 Correlates With Lymph Node Recurrence and Poor Prognosis in Early-stage Tongue Squamous Cell Carcinoma

Cancer Diagnosis & Prognosis
  • MORIYASU YAMAUCHI
  • ,
  • TOMOYA ISHIDA
  • ,
  • AKIMICHI MINESAKI
  • ,
  • YUICHIRO KURATOMI

3
4
開始ページ
457
終了ページ
462
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.21873/cdp.10239
出版者・発行元
Anticancer Research USA Inc.

Background/Aim: Neck management in patients with early-stage tongue cancer remains controversial. The worst pattern of invasion (WPOI) of the primary tumor has been associated with the incidence of regional metastasis. We investigated the prognostic role of WPOI, especially in relation to regional lymph node recurrence and disease-specific survival (DSS). Patients and Methods: We retrospectively reviewed medical records and evaluated tumor specimens of 38 patients with early-stage tongue cancer who underwent primary tumor resection without elective neck dissection. Results: Regional lymph node recurrence rates were significantly higher in patients with WPOI-4/5 compared with WPOI-1 to -3. The 5-year DSS rates were significantly higher for WPOI-1 to -3 than for WPOI-4/5. Notably, patients with WPOI-1 to -3 achieved a 100% 5-year DSS rate with salvage neck dissection and postoperative treatment, even those with cervical lymph node recurrence, whereas patients with WPOI-4/5 had a poorer prognosis. Conclusion: Patients with WPOI-1 to -3 tumors can be followed up without neck dissection until regional lymph node recurrence is detected, with a good course after salvage treatment. In contrast, patients with WPOI-4/5 tumors who are followed up until the appearance of regional lymph node recurrence have a poor prognosis, even with adequate treatment for recurrent disease.

リンク情報
DOI
https://doi.org/10.21873/cdp.10239
ID情報
  • DOI : 10.21873/cdp.10239
  • ISSN : 2732-7787

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