論文

査読有り
2017年2月

Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Kanji Yoshimoto
  • Masataka Nagao
  • Yoshihisa Watanabe
  • Takashi Yamaguchi
  • Shuichi Ueda
  • Yoshihisa Kitamura
  • Kaneyasu Nishimura
  • Masatoshi Inden
  • Yoshinori Marunaka
  • Hiroyuki Hattori
  • Kaori Murakami
  • Megumi Tokaji
  • Kozo Ochi
  • 全て表示

153
開始ページ
1
終了ページ
11
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.pbb.2016.12.001
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Central ghrelin is required for the rewarding properties of drug abuse. We investigated whether alcohol affects ghrelinergic, dopaminergic, and serotoninergic neurons and growth hormone secretagogue receptor 1A (GHS-R1A) levels in the reward system of the brain. Alcohol-naive C57BL/6 J mice received 2 g/kg ethanol (EtOH) intraperitoneally (i.p.). Plasma ghrelin levels decreased between 1 and 4 h. We investigated the effects of EtOH administration on plasma ghrelin levels in two different animal models at 1,3, and 10 months of age. Plasma ghrelin levels decreased following the EtOH treatment in 1- and 3-month-old short-term (1-day) alcohol vapor-exposed (STA) mice. In contrast, EtOH administration increased plasma ghrelin levels in 1- and 3-month-old long-term (20-day) alcohol vapor-exposed (LTA) mice. In vivo ghrelin release in the lateral hypothalamus (LH) increased in STA and LTA mice after the i.p. administration of EtOH. EtOH increased in vivo dopamine (DA), but not serotonin (5-HT) release in the LH of STA mice, and increased in vivo DA and 5-HT release in the LH of LTA mice. GHS-R1A mRNA expression and GHS-R1A protein levels in the LH were increased in LTA mice. The number of GHS-R1A-immunoreactive cells was greater in the LH and amygdala of LTA mice. These results support the neurobiological correlation between the development of drinking behavior and activation of ghrelinergic and serotonergic neurons in the LH. The activation of ghrelinergic systems in the amygdala may also induce an increase in 5-HT release in the LH during long-term alcohol intake. (C) 2016 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.pbb.2016.12.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27940067
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393248100001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.pbb.2016.12.001
  • ISSN : 0091-3057
  • PubMed ID : 27940067
  • Web of Science ID : WOS:000393248100001

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