論文

査読有り
2019年7月

High-grade glioneuronal tumor with an ARHGEF2-NTRK1 fusion gene.

Brain tumor pathology
  • Kazuhiko Kurozumi
  • Yoshiko Nakano
  • Joji Ishida
  • Takehiro Tanaka
  • Masatomo Doi
  • Junko Hirato
  • Akihiko Yoshida
  • Kana Washio
  • Akira Shimada
  • Takashi Kohno
  • Koichi Ichimura
  • Hiroyuki Yanai
  • Isao Date
  • 全て表示

36
3
開始ページ
121
終了ページ
128
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10014-019-00345-y

Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected two cystic lesions bilaterally in the frontal areas with surrounding edema. The left larger tumor was removed by left frontal craniotomy. The tumor was diagnosed as a high-grade glioneuronal tumor, unclassified. Methylation profiling classified it as a diffuse leptomeningeal glioneuronal tumor (DLGNT) with low confidence. This tumor showed genotypes frequently found in DLGNT such as 1p/19q codeletion without IDH mutation and, however, did not have the typical DLGNT clinical and histological features. RNA sequencing identified an ARHGEF2 (encoding Rho/Rac guanine nucleotide exchange factor 2)-NTRK1 fusion gene. The presence of recurrent NTRK fusion in glioneuronal tumors has an important implication in the clinical decision making and opens up a possibility of novel targeted therapy.

リンク情報
DOI
https://doi.org/10.1007/s10014-019-00345-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31011918
ID情報
  • DOI : 10.1007/s10014-019-00345-y
  • ISSN : 1433-7398
  • PubMed ID : 31011918

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