YINJIE YANG - My portal

Profile Information

Researcher number: 90808643
J-GLOBAL ID: 202001020013565403
researchmap Member ID: R000013416

Research Interests

MPN, CALR

Research Areas

Life sciences / Hematology and oncology / MPN

Education

Graduate School of Life Science, Tokyo University of Pharmacy and Life Sciences

Papers

Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms.

Federico De Marchi, Maho Okuda, Soji Morishita, Misa Imai, Terumi Baba, Mei Horino, Yosuke Mori, Chiho Furuya, Satoko Ogata, Yinjie Yang …

Leukemia research, 119 106883-106883, May 31, 2022 Peer-reviewed
Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.

Tadaaki Inano, Marito Araki, Soji Morishita, Misa Imai, Yoshihiko Kihara, Maho Okuda, Yinjie Yang, Masafumi Ito, Satoshi Osaga, Hiroyuki Mano …

Scientific reports, 12(1) 1115-1115, Jan 17, 2022
Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia.

Tadaaki Inano, Marito Araki, Soji Morishita, Misa Imai, Yoshihiko Kihara, Maho Okuda, Yinjie Yang, Masafumi Ito, Satoshi Osaga, Hiroyuki Mano …

Scientific reports, 11(1) 17702-17702, Sep 6, 2021 Peer-reviewed
Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface.

Nami Masubuchi, Marito Araki, Yinjie Yang, Erina Hayashi, Misa Imai, Yoko Edahiro, Yumi Hironaka, Yoshihisa Mizukami, Yoshihiko Kihara, Hiraku Takei …

Leukemia, 34(2) 499-509, Feb, 2020 Peer-reviewed
Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation.

Marito Araki, Yinjie Yang, Misa Imai, Yoshihisa Mizukami, Yoshihiko Kihara, Yoshitaka Sunami, Nami Masubuchi, Yoko Edahiro, Yumi Hironaka, Satoshi Osaga …

Leukemia, 33(1) 122-131, Jan, 2019 Peer-reviewed
Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko …

BLOOD, 130, Dec 7, 2017 Peer-reviewed
Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms.

Marito Araki, Yinjie Yang, Nami Masubuchi, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihisa Mizukami, Shin Kan, Shuichi Shirane, Yoko Edahiro …

Blood, 127(10) 1307-1316, Mar 10, 2016 Peer-reviewed
Activation of AP-1 By JAK2V617F through Induction and Stabilization of c-FOS

Edahiro Yoko, Araki Marito, Hironaka Yumi, Yang Yinjie, Morishita Soji, Sunami Yoshitaka, Ohsaka Akimichi, Komatsu Norio

BLOOD, 126(23), Dec 3, 2015 Peer-reviewed
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B‐positive structures

Alf Håkon Lystad, Yoshinobu Ichimura, Kenji Takagi, Yinjie Yang, Serhiy Pankiv, Yumi Kanegae, Shun Kageyama, Mariko Suzuki, Izumu Saito, Tsunehiro Mizushima …

EMBO reports, 15(5) 557-565, May, 2014 Peer-reviewed
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

Yoshinobu Ichimura, Satoshi Waguri, Yu-shin Sou, Shun Kageyama, Jun Hasegawa, Ryosuke Ishimura, Tetsuya Saito, Yinjie Yang, Tsuguka Kouno, Toshiaki Fukutomi …

Molecular Cell, 51(5) 618-631, Sep, 2013 Peer-reviewed
Deinococcus aetherius sp. nov., isolated from the stratosphere

Yinjie Yang, Takashi Itoh, Shin-ichi Yokobori, Haruo Shimada, Shiho Itahashi, Katsuya Satoh, Hirofumi Ohba, Issay Narumi, Akihiko Yamagishi

International Journal of Systematic and Evolutionary Microbiology, 60(4) 776-779, Apr 1, 2010 Peer-reviewed
TANPOPO: Astrobiology Exposure and Micrometeoroid Capture Experiments-For Understanding Survival Possibility of Microorganisms in Space

Shin-ichi Yokobori, Akihiko Yamagishi, Yinjie Yang, Kenta Fujisaki, Hirofumi Hashimoto, Hideyuki Kawai, Kensei Kobayashi, Hajime Mita, Kyoko Okudaira, Makoto Tabata …

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, 39(3-4) 377-378, Aug, 2009 Peer-reviewed
Deinococcus aerius sp. nov., isolated from the high atmosphere

Y. Yang, T. Itoh, S.-i. Yokobori, S. Itahashi, H. Shimada, K. Satoh, H. Ohba, I. Narumi, A. Yamagishi

International Journal of Systematic and Evolutionary Microbiology, 59(8) 1862-1866, Aug 1, 2009 Peer-reviewed
Bacterial survival in response to desiccation and high humidity at above zero and subzero temperatures

Yinjie Yang, Shin-ichi Yokobori, Akihiko Yamagishi

ADVANCES IN SPACE RESEARCH, 43(8) 1285-1290, Apr, 2009

Misc.

癌原性を有する変異CALRの蓄積を支配するメカニズム(Mechanisms Governing the Accumulation of Mutant CALR Harboring Oncogenic Property)

Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Morishita Soji, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 65(6) 567-567, Dec, 2019
変異分子シャペロンおよびサイトカイン受容体の関与が細胞形質転換に必要である(Engagement of Mutant Molecular Chaperone and Cytokine Receptor in the Secretary is Required for the Cellular Transformation)

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko …

順天堂醫事雑誌, 65(6) 572-573, Dec, 2019
CALRのKDEL配列の喪失およびC末端の陰性荷電から陽性荷電アミノ酸への変化だけでは癌原性は生じない(Loss of KDEL and Conversion from Negatively to Positively Charged Amino Acids at the C-terminus of CALR Was Not Sufficient for the Oncogenicity)

Mizukami Yoshihisa, Araki Marito, Hayashi Erina, Yang Yinjie, Hironaka Yumi, Kihara Yoshihiko, Masubuchi Nami, Imai Misa, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 65(6) 580-581, Dec, 2019
変異calreticulinによるMPN発症の分子メカニズム(The Molecular Mechanism of MPN Development by Mutant Calreticulin)

Edahiro Yoko, Araki Marito, Yang Yinjie, Masubuchi Nami, Mizukami Yoshihisa, Imai Misa, Kihara Yoshihiko, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 65(6) 585-585, Dec, 2019
変異calreticulinの蓄積を支配するメカニズム(Mechanisms Governing the Accumulation of Mutant Calreticulin)

Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Hironaka Yumi, Morishita Soji, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 64(6) 479-480, Dec, 2018
変異calreticulinの腫瘍形成能には分泌経路の構築が必要である(Boarding the Secretory Pathway Is Required for the Oncogenic Capacity of Mutant Calreticulin)

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Kihara Yoshihiko, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko …

順天堂醫事雑誌, 64(6) 480-480, Dec, 2018
変異分子シャペロンはサイトカイン受容体の構成的活性化を介して細胞形質転換を誘導する(A Mutant Molecular Chaperone Induces Cellular Transformation by Constitutive Activation of a Cytokine Receptor)

Araki Marito, Yang Yinjie, Masubuchi Nami, Imai Misa, Hironaka Yumi, Takei Hiraku, Kihara Yoshihiko, Mizukami Yoshihisa, Edahiro Yoko, Ohsaka Akimichi …

順天堂醫事雑誌, 64(6) 486-487, Dec, 2018
ヒト巨核球系UT-7/TPO細胞における癌原性変異calreticulinをモニタリングする生細胞イメージングシステムの開発(Establishment of a Live-Imaging System Monitoring the Oncogenic Mutant Calreticulin in Human Megakaryocytic UT-7/TPO Cells)

Mizukami Yoshihisa, Araki Marito, Hayashi Erina, Yang Yinjie, Hironaka Yumi, Kihara Yoshihiko, Masubuchi Nami, Imai Misa, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 64(6) 494-495, Dec, 2018
骨髄増殖性腫瘍を誘導する変異型calreticulinの細胞内局在(Subcellular Localization of Mutant Calreticulin That Induces Myeloproliferative Neoplasms)

Masubuchi Nami, Araki Marito, Hayashi Erina, Mizukami Yoshihisa, Yang Yinjie, Imai Misa, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 63(6) 476-477, Dec, 2017
Calreticulin変異をもつiPS由来造血幹細胞のトロンボポエチン非依存的な巨核球形成(Thrombopoietin-Independent Megakaryopoiesis in iPS-Derived Hematopoietic Progenitor Cells Harboring Calreticulin Mutation)

Araki Marito, Takei Hiraku, Yang Yinjie, Mizukami Yoshihisa, Masubuchi Nami, Hayashi Erina, Imai Misa, Hironaka Yumi, Morishita Soji, Ohsaka Akimichi …

順天堂醫事雑誌, 63(6) 480-481, Dec, 2017
MPLの活性化は変異型のCALRとMPLの細胞内のおける相互作用を必要とする(Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation)

Masubuchi Nami, Araki Marito, Hayashi Erina, Yang Yinjie, Imai Misa, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Morishita Soji, Kihara Yoshihiko …

臨床血液, 58(9) 1521-1521, Sep, 2017
変異型CALRタンパク質の発現を制御するメカニズム(Mechanisms governing the accumulation of mutant calreticulin)

Kihara Yoshihiko, Araki Marito, Yang Yinjie, Imai Misa, Masubuchi Nami, Mizukami Yoshihisa, Hironaka Yumi, Takei Hiraku, Edahiro Yoko, Ohsaka Akimichi …

臨床血液, 58(9) 1658-1658, Sep, 2017
Calreticulin(CALR)変異を有する骨髄増殖性腫瘍における変異CALRによるトロンボポエチン受容体活性化(Activation of the Thrombopoietin Receptor by Mutant Calreticulin in CALR-Mutant Myeloproliferative Neoplasms)

Araki Marito, Yang Yinjie, Masubuchi Nami, Hironaka Yumi, Takei Hiraku, Morishita Soji, Mizukami Yoshihisa, Ohsaka Akimichi, Komatsu Norio

順天堂醫事雑誌, 62(6) 499-499, Dec, 2016
Calreticulin変異体は骨髄増殖性腫瘍におけるトロンボポエチン受容体を活性化する(Mutant calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms)

Araki Marito, Yang Yinjie, Masubuchi Nami, Hironaka Yumi, Takei Hiraku, Morishita Soji, Mizukami Yoshihisa, Kan Shin, Shirane Shuichi, Edahiro Yoko …

臨床血液, 57(9) 1517-1517, Sep, 2016
骨髄増殖性新生物(MPN)を誘発する変異calreticulinの細胞表面局在(Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms(MPNs))

Masubuchi Nami, Araki Marito, Yang Yinjie, Hironaka Yumi, Takei Hiraku, Morishita Soji, Mizukami Yoshihisa, Kan Shin, Ohsaka Akimichi, Komatsu Norio

臨床血液, 57(9) 1604-1604, Sep, 2016
ACTIVATION OF THE THROMBOPOIETIN RECEPTOR BY MUTANT CALRETICULIN IN CALR-MUTANT MYELOPROLIFERATIVE NEOPLASMS

M. Araki, Y. Yang, N. Masubuchi, Y. Hironaka, H. Takei, S. Morishita, Y. Mizukami, S. Kan, S. Shirane, Y. Edahiro …

HAEMATOLOGICA, 101 164-164, Jun, 2016
たんぽぽ計画[有機物・微生物の宇宙曝露と宇宙塵・微生物の捕集]の準備状況と微生物宇宙生存可能性の検討

横堀伸一, 河口優子, 清水康之, 川尻成俊, 白石啓祐, 杉野朋弘, 高橋勇太, YANG Yinjie, 谷川能章, 橋本博文 …

Viva Origino, 41(Supplement), 2013
Assessing Panspermia Hypothesis by microorganisms collected from the high altitude atmosphere

Yinjie Yang, Shin-ichi Yokobori, Akihiko Yamagishi

Biol. Scie. Space, 23(3) 151-163, 2009
UV-resistant bacteria isolated from upper troposphere and lower stratosphere

Yinjie Yang, Shiho Itahashi, Shin-ichi Yokobori, Akihiko Yamagishi

Biol. Scie. Space, 22(1) 18-25, 2008

Research Projects

Development of novel therapeutic strategies for myeloproliferative neoplasms caused by mutant CALR

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Yang Yinjie
変異CALR遺伝子による骨髄増殖性腫瘍の発症メカニズムの解明

科学研究費助成事業, 奨励研究, 日本学術振興会, 2016 - 2016

楊インジェ