論文

査読有り 国際誌
2019年12月

Novel effect of glucagon-like peptide-2 for hepatocellular injury in a parenterally fed rat model of short bowel syndrome.

Pediatric surgery international
  • Keisuke Yano
  • ,
  • Tatsuru Kaji
  • ,
  • Shun Onishi
  • ,
  • Seiro Machigashira
  • ,
  • Taichiro Nagai
  • ,
  • Toshio Harumatsu
  • ,
  • Koji Yamada
  • ,
  • Waka Yamada
  • ,
  • Mitsuru Muto
  • ,
  • Kazuhiko Nakame
  • ,
  • Motoi Mukai
  • ,
  • Satoshi Ieiri

35
12
開始ページ
1345
終了ページ
1351
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00383-019-04560-8

PURPOSE: Short bowel syndrome (SBS) patients require long-term parenteral nutrition following massive bowel resection, which causes intestinal failure-associated liver disease (IFALD). Previous reports have shown that glucagon-like peptide-2 (GLP-2) resulted in the bowel adaptation for SBS. The aim of this study was to evaluate the effect of GLP-2 for IFALD in a parenterally fed rat model. METHODS: Using rat, a catheter was placed in the jugular vein, and 90% small bowel resection (SBR) was performed. Animals were divided into three groups: SBR and total parenteral nutrition (TPN) (SBS/TPN group), SBR and TPN plus GLP-2 at 1 µg/kg/h [SBS/TPN/GLP-2 (low) group], and SBR and TPN plus GLP-2 at 10 µg/kg/h [SBS/TPN/GLP-2 (high) group]. On day 13, the liver was harvested and analyzed by using nonalcoholic fatty liver disease (NAFLD) score. RESULTS: Histologically, hepatic steatosis in the SBS/TPN group and SBS/TPN/GLP-2 (high) group was observed. Both steatosis and lobular inflammation score in the SBS/TPN/GLP-2 (low) group were significantly lower compared with those in the other two groups (p < 0.05). Active NAFLD score in the SBS/TPN/GLP-2 (low) group was significantly lower compared with that in the SBS/TPN/GLP-2 (high) group (p < 0.01). CONCLUSION: Low-dose GLP-2 intravenous administration improves hepatic steatosis of IFALD following in an SBS parenterally fed rat model.

リンク情報
DOI
https://doi.org/10.1007/s00383-019-04560-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31555865

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