論文

査読有り 国際誌
2019年12月

Microvascular proliferation of the portal vein branches in the liver of biliary atresia patients at Kasai operation is associated with a better long-term clinical outcome.

Pediatric surgery international
  • Toshio Harumatsu
  • ,
  • Toshihiro Muraji
  • ,
  • Ryuta Masuya
  • ,
  • Haruo Ohtani
  • ,
  • Taichiro Nagai
  • ,
  • Keisuke Yano
  • ,
  • Shun Onishi
  • ,
  • Koji Yamada
  • ,
  • Waka Yamada
  • ,
  • Makoto Matsukubo
  • ,
  • Mitsuru Muto
  • ,
  • Tatsuru Kaji
  • ,
  • Satoshi Ieiri

35
12
開始ページ
1437
終了ページ
1441
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00383-019-04579-x

AIM OF THE STUDY: We previously showed an increased number of smaller portal vein (PV) branches in the portal areas of liver biopsy specimens of biliary atresia (BA) patients. We evaluated the correlation between this histopathological feature and the prognosis. PATIENTS AND METHODS: Twenty-five consecutive patients with BA encountered between 2000 and 2012 were classified into three prognostic groups based on their postoperative outcomes: Excellent (n = 11) for native-liver survivors with a normal liver function, Good (n = 6) for native-liver survivors with liver dysfunction, and Poor (n = 8) for survivors after liver transplant or on a waiting list. Data from morphometrical analyses, including the fibrotic portal area, numbers of PVs, diameter and total area of PV branches, were statistically compared among the three groups. MAIN RESULTS: The number of PV branches per unit area of the whole-liver specimen in the poor prognostic group was significantly lower than that in the excellent group (3.1 ± 0.6 vs. 5.2 ± 2.0/mm2, p = 0.03). There were no significant differences in the other parameters. CONCLUSIONS: This is the first report on the relationships between morphometrically analyzed PV branches and the postoperative course in BA patients. The portal venous system is involved as the primary lesion in BA.

リンク情報
DOI
https://doi.org/10.1007/s00383-019-04579-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31542827

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