2016年
Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility
ORGANIC & BIOMOLECULAR CHEMISTRY
ダウンロード
回数 : 23
- 巻
- 14
- 号
- 14
- 開始ページ
- 3608
- 終了ページ
- 3613
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c6ob00276e
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Photoactive molecules with the frameworks of chlorin and/or porphyrin possessing four perfluorinated aromatic rings were conjugated with maltotriose (Mal(3)) via the nucleophilic aromatic substitution reaction and subsequent deprotection reaction of the oligosaccharide moieties. The resulting oligosaccharide-conjugated molecules are ultimately improved as compared to the previously reported monosaccharide-counterparts in terms of water-solubility. In particular, a water-soluble chlorin derivative surrounded by four Mal(3) molecules showed an excellent biocompatibility, strong photoabsorption in the longer wavelength regions, and a very high photocytotoxicity. Thus, the present synthetic route combined with the use of an oligosaccharide was shown to be a straightforward strategy to develop a third generation photosensitizer for photodynamic therapy (PDT).
- リンク情報
- ID情報
-
- DOI : 10.1039/c6ob00276e
- ISSN : 1477-0520
- eISSN : 1477-0539
- PubMed ID : 26978428
- Web of Science ID : WOS:000373636000015