論文

査読有り 国際誌
2020年9月25日

Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats.

Neuroscience letters
  • Yuri Kitagawa
  • ,
  • Takuya Sasaki
  • ,
  • Reika Suzumura
  • ,
  • Ai Morishima
  • ,
  • Ryoki Tatebayashi
  • ,
  • Assadullah
  • ,
  • Nahoko Ieda
  • ,
  • Yasuhiro Morita
  • ,
  • Shuichi Matsuyama
  • ,
  • Naoko Inoue
  • ,
  • Yoshihisa Uenoyama
  • ,
  • Hiroko Tsukamura
  • ,
  • Satoshi Ohkura

736
開始ページ
135276
終了ページ
135276
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neulet.2020.135276

Pulsatile gonadotropin-releasing hormone (GnRH) secretion is essential for regulating reproductive functions in mammals. GnRH pulses are governed by a neural mechanism that is termed the GnRH pulse generator. In the present study, we investigated the role of central calcitonin receptor (CTR) signaling in the regulation of the GnRH pulse generator activity in ovariectomized goats by administering amylin, an endogenous ligand for CTR, into the lateral ventricle. GnRH pulse generator activity was measured using multiple unit activity (MUA) recordings in the mediobasal hypothalamus. We analyzed changes in the interval of characteristic increases in MUA (MUA volleys). The MUA volley interval shortened immediately after amylin administration, followed by prolonged intervals. Double in situ hybridization for KISS1 (kisspeptin gene) and CALCR (CTR gene) revealed that low expression levels of CALCR were found in the arcuate kisspeptin neurons, which is suggested as the main population of neurons, involved in GnRH pulse generator activity. These results suggest that central amylin-CTR signaling has a biphasic role in the regulation of GnRH pulse generator activity by acting on cells other than the arcuate kisspeptin neurons in goats.

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2020.135276
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32771877

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