2021年6月21日
Markers of cardiovascular disease risk in sleep-disordered breathing with or without comorbidities: the Nagahama Study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
- 巻
- 17
- 号
- 12
- 開始ページ
- 2467
- 終了ページ
- 2475
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.5664/jcsm.9460
STUDY OBJECTIVES: Whether the association between sleep-disordered breathing (SDB) and cardiovascular disease (CVD) is independent of comorbid risk factors for CVD is controversial. The objective of this study is to elucidate whether the association between SDB severity and the surrogate markers of CVD evets differs in relation to the number of comorbidities. METHODS: This cross-sectional study included 7731 participants. Severity of SDB was determined by the oxygen desaturation index adjusted by actigraph-measured objective sleep time. Participants were stratified according to SDB severity and the number of comorbidities (hypertension, diabetes, dyslipidemia and obesity), and the associations between the maximum value of intima-media thickness of the common carotid artery (CCA-IMT-max), brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) were evaluated. RESULTS: Among participants with no risk factor, CCA-IMT-max increased according to SDB severity (n = 1022, P <0.0001). Even after the matching of background, the median CCA-IMT-max value was 14% higher in moderate-severe SDB cases than those without SDB (n=45 in each group, P=0.020). The difference was not significant for baPWV and CAVI. On the other hand, a significant difference in CCA-IMT-max was not found in those with multiple comorbidities. Consistently, multiple regression analysis revealed an independent association between CCA-IMT-max and moderate-severe SDB for all study participants (β: 0.0222 (95% confidence interval: 0.0039-0.0405), P=0.017), but the association was not significant for stratified participants with multiple comorbidities. CONCLUSIONS: SDB severity is associated with the CCA-IMT-max level, but the independent association becomes weaker for those with multiple comorbidities.
- リンク情報
- ID情報
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- DOI : 10.5664/jcsm.9460
- PubMed ID : 34170234
- PubMed Central 記事ID : PMC8726369