MISC

2016年

2D21 細胞における収縮力-形状フィードバックを考慮した上皮細胞の形態変化シミュレーション

バイオエンジニアリング講演会講演論文集
  • 榎本 祥英
  • ,
  • 井上 康博
  • ,
  • 米村 重信
  • ,
  • 安達 泰治

2016
0
開始ページ
_2D21
終了ページ
1_-_2D21-5_
記述言語
日本語
掲載種別
DOI
10.1299/jsmebio.2016.28._2D21-1_
出版者・発行元
一般社団法人 日本機械学会

Epithelial tissue constitutes many kinds of organs of multicellular organisms. During morphogenesis, tissue deformation is driven by forces generated by cell activities such as cell proliferation, cell migration and apical constriction. Because shape of organs is accomplished appropriately by a series of tissue deformation, force generation at cell level can be controlled by a result of tissue shaping in a feedback manner. As such a mechanism, we suggest a function of modifying apical constriction in response to cell shape change by mechanosensitivity of alpha-catenin, leading to the feedback relationship between apical constriction and cell shape. In this study, we construct a mathematical model of the feedback relationship and investigate its role in formation of tissue shape. Simulation results suggest that the modification is based on the shapes of adjacent cells, and that the function maintains roundness of epithelial tissue by averaging the cell shapes.

リンク情報
DOI
https://doi.org/10.1299/jsmebio.2016.28._2D21-1_
CiNii Articles
http://ci.nii.ac.jp/naid/110010052181

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