2015年
Three-dimensional vertex model for simulating multicellular morphogenesis
BIOPHYSICS AND PHYSICOBIOLOGY
- ,
- ,
- 巻
- 12
- 号
- 開始ページ
- 13
- 終了ページ
- 20
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2142/biophysico.12.0_13
- 出版者・発行元
- BIOPHYSICAL SOC JAPAN
During morphogenesis, various cellular activities are spatio-temporally coordinated on the protein regulatory background to construct the complicated, three-dimensional (3D) structures of organs. Computational simulations using 3D vertex models have been the focus of efforts to approach the mechanisms underlying 3D multicellular constructions, such as dynamics of the 3D monolayer or multi-layer cell sheet like epithelia as well as the 3D compacted cell aggregate, including dynamic changes in layer structures. 3D vertex models enable the quantitative simulation of multicellular morphogenesis on the basis of single-cell mechanics, with complete control of various cellular activities such as cell contraction, growth, rearrangement, division, and death. This review describes the general use of the 3D vertex model, along with its applications to several simplified problems of developmental phenomena.
- リンク情報
- ID情報
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- DOI : 10.2142/biophysico.12.0_13
- ISSN : 2189-4779
- Web of Science ID : WOS:000449104900002