2013年9月
Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study
JOURNAL OF PHYSIOLOGICAL SCIENCES
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- ,
- ,
- 巻
- 63
- 号
- 5
- 開始ページ
- 355
- 終了ページ
- 367
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12576-013-0271-x
- 出版者・発行元
- SPRINGER JAPAN KK
Early embryonic rodent ventricular cells exhibit spontaneous action potential (AP), which disappears in later developmental stages. Here, we used 3 mathematical models-the Kyoto, Ten Tusscher-Panfilov, and Luo-Rudy models-to present an overview of the functional landscape of developmental changes in embryonic ventricular cells. We switched the relative current densities of 9 ionic components in the Kyoto model, and 160 of 512 representative combinations were predicted to result in regular spontaneous APs, in which the quantitative changes in Na+ current (I (Na)) and funny current (I (f)) made large contributions to a wide range of basic cycle lengths. In all three models, the increase in inward rectifier current (I (K1)) before the disappearance of I (f) was predicted to result in abnormally high intracellular Ca2+ concentrations. Thus, we demonstrated that the developmental changes in APs were well represented, as I (Na) increased before the disappearance of I (f), followed by a 10-fold increase in I (K1).
- リンク情報
- ID情報
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- DOI : 10.1007/s12576-013-0271-x
- ISSN : 1880-6546
- Web of Science ID : WOS:000323642300004