論文

査読有り
2014年7月

Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans

SCIENCE
  • Hayao Ohno
  • ,
  • Shinya Kato
  • ,
  • Yasuki Naito
  • ,
  • Hirofumi Kunitomo
  • ,
  • Masahiro Tomioka
  • ,
  • Yuichi Iino

345
6194
開始ページ
313
終了ページ
317
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/science.1250709
出版者・発行元
AMER ASSOC ADVANCEMENT SCIENCE

The phosphatidylinositol 3-kinase (PI3K) pathway regulates many cellular functions, but its roles in the nervous system are still poorly understood. We found that a newly discovered insulin receptor isoform, DAF-2c, is translocated from the cell body to the synaptic region of the chemosensory neuron in Caenorhabditis elegans by a conditioning stimulus that induces taste avoidance learning. This translocation is essential for learning and is dependent on the mitogen-activated protein kinase-regulated interaction of CASY-1 (the calsyntenin ortholog) and kinesin-1. The PI3K pathway is required downstream of the receptor. Light-regulated activation of PI3K in the synaptic region, but not in other parts of the cell, switched taste-attractive behavior to taste avoidance, mimicking the effect of conditioning. Thus, synaptic PI3K is crucial for the behavioral switch caused by learning.

Web of Science ® 被引用回数 : 35

リンク情報
DOI
https://doi.org/10.1126/science.1250709
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000339400700048&DestApp=WOS_CPL