Yasunori Tome

Profile Information

Affiliation: 准教授, 整形外科学講座, 琉球大学大学院医学研究科

Degree: 博士（医学）(琉球大学大学院)

J-GLOBAL ID: 201501093218772394
researchmap Member ID: B000245386

External link: https://kaken.nii.ac.jp/d/r/20547369.ja.html

Research Interests

Research Areas

Life sciences / Orthopedics /

Research History

Nov, 2017 - Present

Associate Professor, Department of Orthopedic Surgery, University of the Ryukyus, Graduate School of Medicine
Oct, 2014 - Oct, 2017

Center for Hyperbaric Medicine and Environmental Health, University of the Ryukyus, University Hospital, Faculty of Medicine

Education

Apr, 2006 - Mar, 2010

Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus
Apr, 1996 - Mar, 2002

School of Medicine, Faculty of Medicine, University of the Ryukyus

Committee Memberships

Jun, 2021 - Present

安全医療推進・感染対策委員, 日本整形外科学会
Aug, 2020 - Present

評議員, 日本サルコーマ治療研究学会

Awards

Sep, 2020

優秀ポスター賞, 骨巨細胞腫の中期治療成績, 第53回日本整形外科学会骨・軟部腫瘍学術集会

當銘保則、大城裕理、当真孝、前原博樹、西田康太郎
Jul, 2014

最優秀ポスター賞, Nestin マウスにおける骨肉腫新生血管の real-time color-coded in vivo imaging, 第47回日本整形外科学会骨・軟部腫瘍学術集会

上原史成, 當銘保則, 前原博樹, 田中一広, Robert M. Hoffma, 金谷文則

Papers

Packing with alpha-tricalcium phosphate followed by curettage and phenol-ethanol ablation for appendicular giant cell tumor of bone

Hiromichi Oshiro, Yasunori Tome, Yuichi Tsuha, Yusuke Aoki, Kohei Mizuta, Kotaro Nishida

Medicine, 101(49) e32055-e32055, Dec 9, 2022 Peer-reviewedCorresponding author
Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation

Yusuke Aoki, Qinghong Han, Yasunori Tome, Jun Yamamoto, Yutaro Kubota, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Justin D. Wang, Sachiko Inubushi, Michael Bouvet, Steven G. Clarke, Kotaro Nishida, Robert M. Hoffman

Frontiers in Oncology, 12 1009548, Nov 3, 2022 Peer-reviewedCorresponding author
Wide excision alone for elderly patients aged > 70 years old with soft tissue sarcomas

Yusuke Aoki, Yasunori Tome, Hiromichi Oshiro, Ryo Katsuki, Tomoko Tamaki, Naoki Wada, Kennosuke Karube, Kotaro Nishida

Medicine, 101(36) e30127, Sep 9, 2022 Peer-reviewedCorresponding author
Veno-accompanying artery fasciocutaneous flaps following wide excision of soft tissue tumors in the lower legs

Yusuke Aoki, Yasunori Tome, Hiromichi Oshiro, Masaki Kinjo, Hirotaka Okubo, Motoko Nakasone, Kotaro Nishida

Journal of Orthopaedic Science, 27(5) 1126-1131, Sep, 2022 Peer-reviewedCorresponding author
C2 Radiculopathy Due to a Retro-Odontoid Pseudotumor: A Case Report

Hideo Kinjo, Takanao Shimabukuro, Chikashi Yamakawa, Shogo Fukase, Yasunori Tome, Kotaro Nishida

Spine Surgery and Related Research, 6(4) 412-415, Jul 27, 2022 Peer-reviewedCorresponding author
Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer

YUSUKE AOKI, NORIYUKI MASAKI, YASUNORI TOME, YUTARO KUBOTA, YASUYO AOKI, MICHAEL BOUVET, KOTARO NISHIDA, ROBERT M. HOFFMAN

In Vivo, 36(4) 1647-1650, Jul, 2022 Peer-reviewedCorresponding author
凍結同種保存骨移植を脊椎固定術へ使用した経験

金城英雄, 島袋孝尚, 山川慶, 深瀬昌悟, 大城裕理, 仲宗根哲, 當銘保則, 西田康太郎

整形外科と災害外科, 71(Suppl.1) 76-76, May, 2022
Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase

YUSUKE AOKI, YASUNORI TOME, QINGHONG HAN, JUN YAMAMOTO, KAZUYUKI HAMADA, NORIYUKI MASAKI, YUTARO KUBOTA, MICHAEL BOUVET, KOTARO NISHIDA, ROBERT M. HOFFMAN

Cancer Genomics - Proteomics, 19(3) 299-304, May, 2022 Peer-reviewedCorresponding author
Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma: A case report

Hirotaka Yonezawa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Sei Morinaga, Yohei Asano, Shiro Saito, Yasunori Tome, Hiroko Ikeda, Takayuki Nojima, Hiroyuki Tsuchiya

World Journal of Clinical Cases, 10(10) 3297-3305, Apr 6, 2022 Peer-reviewed
Long-Term Results of Kyocera Modular Limb Salvage System after Resection of Tumors in the Distal Part of the Femur: Report from Japanese Musculoskeletal Oncology Group Study

Tomoki Nakamura, Akihiko Matsumine, Yu Toda, Satoshi Takenaka, Hidetatsu Outani, Tomohiro Fujiwara, Yoshihiro Nishida, Satoshi Tsukushi, Yasunori Tome, Teruya Kawamoto, Munehisa Kito, Naohiro Shinohara, Masato Tomita, Tomoaki Torigoe, Akihiro Sudo, Hirotaka Kawano

Cancers, 14(4) 870-870, Feb 10, 2022 Peer-reviewed
Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model

YUSUKE AOKI, YASUNORI TOME, QINGHONG HAN, JUN YAMAMOTO, KAZUYUKI HAMADA, NORIYUKI MASAKI, YUTARO KUBOTA, MICHAEL BOUVET, KOTARO NISHIDA, ROBERT M. HOFFMAN

Anticancer Research, 42(2) 731-737, Feb, 2022 Peer-reviewedCorresponding author
Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation

Yusuke Aoki, Yasunori Tome, Qinghong Han, Jun Yamamoto, Kazuyuki Hamada, Noriyuki Masaki, Michael Bouvet, Kotaro Nishida, Robert M. Hoffman

Biochemistry and Biophysics Reports, 28 101177-101177, Dec, 2021 Peer-reviewedCorresponding author
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models

YUSUKE AOKI, JUN YAMAMOTO, YASUNORI TOME, KAZUYUKI HAMADA, NORIYUKI MASAKI, SACHIKO INUBUSHI, YOSHIHIKO TASHIRO, MICHAEL BOUVET, ITARU ENDO, KOTARO NISHIDA, ROBERT M. HOFFMAN

Cancer Genomics - Proteomics, 18(6) 715-721, Nov, 2021 Peer-reviewedCorresponding author
Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease

HIROMICHI OSHIRO, YASUNORI TOME, KENTARO MIYAKE, TAKASHI HIGUCHI, NORIHIKO SUGISAWA, FUMINORI KANAYA, KOTARO NISHIDA, ROBERT M. HOFFMAN

Anticancer Research, 41(7) 3287-3292, Jul, 2021 Peer-reviewedCorresponding author
当科における大腿骨近位部骨折後の骨粗鬆症治療の現状と取り組み

島袋孝尚, 仲宗根哲, 東千夏, 金城政樹, 當銘保則, 神谷武志, 西田康太郎

沖縄医学会雑誌, 60(1) 77-77, Jun, 2021
An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model

Hiromichi Oshiro, Yasunori Tome, Kentaro Miyake, Takashi Higuchi, Norihiko Sugisawa, Fuminori Kanaya, Kotaro Nishida, Robert M. Hoffman

Scientific Reports, 11(1) 8583-8583, Apr 21, 2021 Peer-reviewedCorresponding author
Reconstruction of the elbow using pedicle joint freezing after wide excision for soft tissue sarcoma: A case report

Yuta Hashimoto, Yasunori Tome, Hiromichi Oshiro, Yusuke Aoki, Hiroki Maehara, Kotaro Nishida

Molecular and Clinical Oncology, 14(6) 115, Apr 8, 2021 Peer-reviewedCorresponding author
Oral-recombinant Methioninase Converts an Osteosarcoma from Docetaxel-resistant to -Sensitive in a Clinically-relevant Patient-derived Orthotopic-xenograft (PDOX) Mouse Model

YUSUKE AOKI, YASUNORI TOME, NATHANIEL F. WU, JUN YAMAMOTO, KAZUYUKI HAMADA, QINGHONG HAN, MICHAEL BOUVET, KOTARO NISHIDA, ROBERT M. HOFFMAN

Anticancer Research, 41(4) 1745-1751, Apr, 2021 Peer-reviewedCorresponding author
A Novel Orthotopic Mouse Model of Lung Metastasis Using Fluorescent Patient-derived Osteosarcoma Cells

HIROMICHI OSHIRO, YASUNORI TOME, KENTARO MIYAKE, TAKASHI HIGUCHI, NORIHIKO SUGISAWA, JUN HO PARK, ZHIYING ZHANG, SAHAR RAZMJOOEI, FUMINORI KANAYA, KOTARO NISHIDA, ROBERT M. HOFFMAN

Anticancer Research, 41(2) 635-640, Feb, 2021 Peer-reviewedCorresponding author
当院における両側同時人工膝関節置換術の臨床成績

藤本泰毅, 東千夏, 比嘉浩太郎, 翁長正道, 松田英敏, 石原昌人, 仲宗根哲, 神谷武志, 當銘保則, 西田康太郎

整形外科と災害外科, 69(4) 864-866, Sep, 2020

Misc.

209

悪性軟部腫瘍に対して片側皮質骨切除後に自家液体窒素処理骨移植を施行した4例

山城正一郎, 當銘保則, 大城裕理, 青木佑介, 石川樹, 西田康太郎

整形外科と災害外科, 69(Suppl.2) 235-235, Oct, 2020
70歳以上の軟部肉腫患者に対する広範囲切除単独療法の治療成績

青木佑介, 當銘保則, 大城裕理, 石川樹, 山城正一郎, 西田康太郎

整形外科と災害外科, 69(Suppl.2) 237-237, Oct, 2020
当院における骨原発Langerhans cell histiocytosis(LCH)の検討

石川樹, 當銘保則, 大城裕理, 青木佑介, 山城正一郎, 西田康太郎

整形外科と災害外科, 69(Suppl.2) 240-240, Oct, 2020
ウサギ大腿骨hemiepiphysiodesisモデルにおけるインプラント除去後の内外側成長軟骨板の骨成長に関する検討

神谷武志, 知念修子, 比嘉浩太郎, 上原史成, 仲宗根素子, 大久保宏貴, 東千夏, 金城政樹, 當銘保則, 西田康太郎

日本整形外科学会雑誌, 94(8) S1792-S1792, Sep, 2020
骨肉腫ヒト由来同所移植マウス(PDOX)モデルと血管新生評価モデルにおけるmTOR阻害薬とVEGFR阻害薬の併用療法の治療効果の検討

大城裕理, 當銘保則, 青木祐介, Hoffman Robert, 西田康太郎

日本整形外科学会雑誌, 94(8) S1980-S1980, Sep, 2020
骨肉腫ヒト由来同所移植マウス(PDOX)モデルに対するCDK4/6阻害薬とmTOR阻害薬の併用療法における治療効果の検討

大城裕理, 當銘保則, 当真孝, 前原博樹, Hoffman Robert, 西田康太郎

日本整形外科学会雑誌, 94(6) S1407-S1407, Jul, 2020
下肢悪性骨・軟部腫瘍患者の術前炎症反応は術後創部感染を予測するか

長嶺覚子, 當銘保則, 知花由晃, 大城裕理, 当真孝, 神谷武志, 西田康太郎

日本整形外科学会雑誌, 94(6) S1476-S1476, Jul, 2020
骨巨細胞腫の中期治療成績

當銘保則, 大城裕理, 当真孝, 前原博樹, 西田康太郎

日本整形外科学会雑誌, 94(6) S1485-S1485, Jul, 2020
長管骨類骨骨腫に対して術中CTナビゲーション手術を施行した3例

當銘保則, 大城裕理, 青木祐介, 西田康太郎

整形外科と災害外科, 69(Suppl.1) 211-211, May, 2020
異所性に発生し異なる組織型を示した脂肪肉腫の1例

大城裕理, 當銘保則, 青木祐介, 西田康太郎

整形外科と災害外科, 69(Suppl.1) 212-212, May, 2020
CDK4/6阻害薬とmTOR阻害薬併用療法は骨肉腫のヒト由来同所移植マウス(PDOX)モデルにおいて抗腫瘍効果を示す

大城裕理, 當銘保則, 当真孝, 前原博樹, Hoffman Robert, 西田康太郎

日本整形外科学会雑誌, 94(2) S250-S250, Mar, 2020
下肢悪性骨・軟部腫瘍における自家液体窒素処理骨とパスツール処理骨の比較検討

當銘保則, 大城裕理, 当真孝, 前原博樹, 西田康太郎

日本整形外科学会雑誌, 94(2) S335-S335, Mar, 2020
肩腱板広範囲断裂を合併した肩関節不安定症の1例

津覇雄一, 山口浩, 当真孝, 呉屋五十八, 森山朝裕, 大城裕理, 當銘保則, 西田康太郎

整形外科と災害外科, 68(Suppl.2) 74-74, Nov, 2019
肩関節後方脱臼骨折術後に再脱臼をきたした1例

親富祖徹, 山口浩, 当真孝, 呉屋五十八, 森山朝裕, 大城裕理, 當銘保則, 砂川秀之, 西田康太郎

整形外科と災害外科, 68(Suppl.2) 81-81, Nov, 2019
左踵骨に発生したchondroblastomaの1例

大城裕理, 當銘保則, 当真孝, 西田康太郎

整形外科と災害外科, 68(Suppl.2) 90-90, Nov, 2019
当院における両側同時人工膝関節置換術(TKA)の臨床成績

藤本泰毅, 東千夏, 山中理菜, 比嘉浩太郎, 翁長正道, 松田英敏, 石原昌人, 仲宗根哲, 神谷武志, 當銘保則, 西田康太郎

整形外科と災害外科, 68(Suppl.2) 159-159, Nov, 2019
血清コレステロール値が正常を示した腱黄色腫の1例

蛯子隼, 金城政樹, 村上弘, 赤嶺良幸, 當銘保則

整形外科と災害外科, 68(Suppl.2) 165-165, Nov, 2019
大腿骨悪性骨腫瘍に対する腫瘍用人工関節の治療成績

當銘保則, 大城裕理, 当真孝, 西田康太郎

整形外科と災害外科, 68(Suppl.2) 171-171, Nov, 2019
乳がん術後の肩関節機能障害に対するリハビリテーションの有用性

当真孝, 山口浩, 呉屋五十八, 森山朝裕, 當銘保則

日本肩関節学会抄録集, 46回 366-366, Oct, 2019
ウサギ大腿骨hemiepiphysiodesisモデルにおけるインプラント除去後の成長軟骨板の骨形態評価

神谷武志, 山中理菜, 比嘉浩太郎, 親川知, 松田英敏, 石原昌人, 仲宗根哲, 東千夏, 當銘保則, 金谷文則

日本整形外科学会雑誌, 93(8) S1619-S1619, Sep, 2019

Professional Memberships

Research Projects

骨肉腫における抗がん剤耐性や肺転移に関するマイクロRNAの解析

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2025

當銘保則
Analysis of micro RNA related to osteosarcoma metastasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Tome Yasunori, Kiyuna Tasuku, Oshiro Hiromichi

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