論文

国際誌
2020年11月23日

On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency.

Scientific reports
  • Taisuke Takayanagi
  • Tomoki Uesaka
  • Yuta Nakamura
  • Mehmet Burcin Unlu
  • Yasutoshi Kuriyama
  • Tomonori Uesugi
  • Yoshihiro Ishi
  • Nobuki Kudo
  • Masanori Kobayashi
  • Kikuo Umegaki
  • Satoshi Tomioka
  • Taeko Matsuura
  • 全て表示

10
1
開始ページ
20385
終了ページ
20385
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-77422-2

In contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-77422-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33230208
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683547
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85096437749&partnerID=MN8TOARS 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85096437749&origin=inward
ID情報
  • DOI : 10.1038/s41598-020-77422-2
  • ISSN : 2045-2322
  • eISSN : 2045-2322
  • ORCIDのPut Code : 134699342
  • PubMed ID : 33230208
  • PubMed Central 記事ID : PMC7683547
  • SCOPUS ID : 85096437749

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