論文

査読有り 招待有り 本文へのリンクあり 国際誌
2021年1月15日

Involvement of Netrins and Their Receptors in Neuronal Migration in the Cerebral Cortex

Frontiers in Cell and Developmental Biology
  • Satoru Yamagishi
  • ,
  • Yuki Bando
  • ,
  • Kohji Sato

8
開始ページ
590009
終了ページ
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fcell.2020.590009
出版者・発行元
Frontiers Media SA

In mammals, excitatory cortical neurons develop from the proliferative epithelium and progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the cortical plate, whereas inhibitory GABAergic interneurons are born in the ganglionic eminence and migrate tangentially. The migration of newly born cortical neurons is tightly regulated by both extracellular and intracellular signaling to ensure proper positioning and projections. Non-cell-autonomous extracellular molecules, such as growth factors, axon guidance molecules, extracellular matrix, and other ligands, play a role in cortical migration, either by acting as attractants or repellents. In this article, we review the guidance molecules that act as cell–cell recognition molecules for the regulation of neuronal migration, with a focus on netrin family proteins, their receptors, and related molecules, including neogenin, repulsive guidance molecules (RGMs), Down syndrome cell adhesion molecule (DSCAM), fibronectin leucine-rich repeat transmembrane proteins (FLRTs), and draxin. Netrin proteins induce attractive and repulsive signals depending on their receptors. For example, binding of netrin-1 to deleted in colorectal cancer (DCC), possibly together with Unc5, repels migrating GABAergic neurons from the ventricular zone of the ganglionic eminence, whereas binding to α3β1 integrin promotes cortical interneuron migration. Human genetic disorders associated with these and related guidance molecules, such as congenital mirror movements, schizophrenia, and bipolar disorder, are also discussed.

リンク情報
DOI
https://doi.org/10.3389/fcell.2020.590009 本文へのリンクあり
URL
https://www.frontiersin.org/articles/10.3389/fcell.2020.590009/full 本文へのリンクあり
ID情報
  • DOI : 10.3389/fcell.2020.590009
  • eISSN : 2296-634X

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