2018年3月
Microgram-scale X-ray Structure Analysis of Small Molecules via High-throughput Co-crystallization
Chemistry Letters
- ,
- ,
- ,
- 巻
- 47
- 号
- 5
- 開始ページ
- 617
- 終了ページ
- 619
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.180082
- 出版者・発行元
- Chemical Society of Japan
A microgram-scale X-ray structure analysis of small molecules was developed by applying a modern high-throughput crystallization technique to classical co-crystallization via acid-base salt formation. The use of an automatic dispensing machine for the crystallization screening reduces the required amount of sample to the microgram scale. Absolute configurations of a chiral alkaloid and three chiral pharmaceutical acids were obtained by X-ray crystallography from 210530 μg of samples by this renovated method.
- リンク情報
- ID情報
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- DOI : 10.1246/cl.180082
- ISSN : 1348-0715
- ISSN : 0366-7022
- SCOPUS ID : 85045508279
- Web of Science ID : WOS:000431807100004