Yuki Fujii

Profile Information

Affiliation: Nagasaki International University
: Yokohama City University

Degree: 博士（理学）(横浜市立大学)

Researcher number: 80610063
J-GLOBAL ID: 201301039474516363
researchmap Member ID: B000234521

External link: https://scholar.google.co.jp/citations?hl=en&user=JcIhJB8AAAAJ&view_op=list_works&sortby=pubdate

1981年横浜生まれ。幼稚園(4歳)から小学校の途中(9歳)までをニューヨークですごし、英語は子供の時から苦労してきました。成蹊大で有機化学、横浜市立大大学院でタンパク質と糖鎖を学び、東北薬科大、パシフィックノースウェスト糖尿病研、ミネソタ大発生生物学センターで糖鎖生物学を研究しました。長崎国際大薬学部の専任に加わり、教育、研究、地域貢献、学内業務にバランスよく取り組める大学教員を目指しています。

有明海や諫早湾、五島列島など、長崎には多様性に富む豊かな海域があります。地中海のトリエステ大と協力し、海洋無脊椎動物から創薬・診断や環境評価に役立つレクチン(糖鎖結合性タンパク)とその遺伝子を探索しています。

Research Interests

Research Areas

Research History

Apr, 2022 - Present

(准教授), 長崎国際大学薬学部薬学科機能形態学研究室
Mar, 2012 - Present

Visiting Senior Assistan Professor, Yokohama City University
Apr, 2017 - Mar, 2021

The Faculty of Pharmaceutical Sciences, Nagasaki International University
Apr, 2012 - Mar, 2017

The Faculty of Pharmaceutical Sciences, Nagasaki International University
Apr, 2011 - Aug, 2011

Post-Doc Scientist, Dep of Genetics and Developmental Biology, The University of Minnesota
Apr, 2010 - Mar, 2011

Post-Doc Researcher, Institute of Molecular Biomenbrane and Glycobiology, Tohoku Medical and Pharmaceutical Univ
Jun, 2006 - Dec, 2006

NIH Visiting Scientist, Pacific Northwest Diabetes Research Institute

Education

Apr, 2007 - Mar, 2010

Graduate, Yokohama City University
Apr, 2005 - Mar, 2007

Graduate, Yokohama City University
Apr, 2001 - Mar, 2005

Department of Applied Chemistry, Faculty of Engineering, Seikei University

Awards

Research Projects

実験と計算科学の融合による任意の標的ガングリオシドに選択的な人工レクチンの開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2027

藤井佑樹
チロシナーゼ分解誘導化合物によるメラノーマ腫瘍形成抑制の分子機構解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

藤田英明, 上田亮太, 藤井佑樹
Studies on Comparative Glycomics of Marine Invertebrate Lectins

2022 The Assisted Joint Research Program, Exploration Type, J-GlycoNet, Nov, 2022 - Mar, 2023

Yann Guerardel, Yuki Fujii, Jun Koseki, Masao Yamada, Ryuya Ishiwata, Ryuhei Hayashi, Shyun Takakusaki, Suzuna Yoshimoto, Teppei Shimamura
人工レクチンの糖鎖認識原理の解明

公募型共同研究, 糖鎖生命コア研究所, Dec, 2021 - Mar, 2022
レクチンによる免疫細胞の活性化と計算科学を用いたその改良

学長裁量経費（科研費チャレンジ）, 長崎国際大学, Jul, 2021 - Mar, 2022

藤井佑樹
The defensive properties of beta-trefoil fold lectins in bivalve Mytilidae

Grant-in-Aid for Scientific Research (C), JSPS, Apr, 2019 - Mar, 2022

Yasuhiro Ozeki
冬虫夏草菌シアル酸結合性レクチンを用いた糖尿病性インスリンレセプターの回復技術

基盤研究C（分担）, 日本学術振興会：科学研究費補助金, Apr, 2018 - Mar, 2021

小川由起子
二枚貝レクチンを用いた免疫細胞の増殖制御と創薬に関する研究

杉山産業化学研究所研究助成, 杉山産業化学研究所, 2019 - 2020
アシアロGM1結合レクチンを用いた自己免疫疾患治療薬の開発

学長裁量経費科(科研費チャレンジ), 長崎国際大学, Jun, 2018 - 2019

藤井佑樹
精子形成細胞の分化研究を明らかにする免疫電顕クロマトイドミクス解析

科学研究費補助金若手研究（B）, 日本学術振興会, Apr, 2013 - Mar, 2016

藤井佑樹

Papers

Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination.

Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Membranes, 14(2), Feb 1, 2024
Physicochemical properties and antimicrobial activities of MytiLec-1, a member from the mytilectin family of mussels

Md. Mikail Hossain, Sultana Rajia, Mayuka Ohkawa, Suzuna Yoshimoto, Yuki Fujii, Sarkar M.A. Kawsar, Yasuhiro Ozeki, Imtiaj Hasan

International Journal of Biological Macromolecules, 253 127628-127628, Dec, 2023
Coming New Age of Marine Glycomics: The Fundamental, Medical, and Ecological Aspects

Yuki Fujii, Marco Gerdol, Yasuhiro Ozeki

Marine Drugs, 20(10) 613-613, Sep 28, 2022 Peer-reviewedInvitedLead author
Methyl β-D-galactopyranoside esters as potential inhibitors for SARS-CoV-2 protease enzyme: synthesis, antimicrobial, PASS, molecular docking, molecular dynamics simulations and quantum computations.

Md R Amin, Farhana Yasmin, Sujan Dey, Shafi Mahmud, Md A Saleh, Talha B Emran, Imtiaj Hasan, Sultana Rajia, Yukiko Ogawa, Yuki Fujii …

Glycoconjugate journal, 39(2) 261-290, Apr, 2022
Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations & Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside Analogs

Md. Ruhul Amin, Farhana Yasmin, Mohammed Anowar Hosen, Sujan Dey, Shafi Mahmud, Md. Abu Saleh, Talha Bin Emran, Imtiaj Hasan, Yuki Fujii, Masao Yamada …

Molecules, 26(22) 7016-7016, Nov 20, 2021
Geometrical optimization, PASS prediction, molecular docking, and in silico ADMET studies of thymidine derivatives against FimH adhesin of Escherichia coli

M. Anowar Hosen, A. Alam, M. Islam, Y. Fujii, Y. Ozeki, S. M. Abe Kawsar

Bulgarian Chemical Communications, 53(3) 327-342, Oct 10, 2021 Peer-reviewed
Diverse Localization Patterns of an R-Type Lectin in Marine Annelids

Sarkar M. Abe Kawsar, Imtiaj Hasan, Sultana Rajia, Yasuhiro Koide, Yuki Fujii, Ryuhei Hayashi, Masao Yamada, Yasuhiro Ozeki

Molecules, 26(16) 4799-4799, Aug 7, 2021 Peer-reviewed
Antiproliferative and Antimicrobial Potentials of a Lectin from Aplysia kurodai (Sea Hare) Eggs

Rubaiya Rafique Swarna, A. K. M. Asaduzzaman, Syed Rashel Kabir, Nawshin Arfin, Sarkar M. A. Kawsar, Sultana Rajia, Yuki Fujii, Yukiko Ogawa, Keisuke Hirashima, Nanae Kobayashi …

Marine Drugs, 19(7) 394-394, Jul 14, 2021 Peer-reviewed
Cell Function Research of β-Trefoil Lectins from Mytilidae

Yuki Fujii

YAKUGAKU ZASSHI, 141(4) 481-488, Apr 1, 2021 Peer-reviewedInvitedLead authorCorresponding author
Pharmacokinetics and Molecular Docking Studies of Uridine Derivatives as SARS-COV-2 Mpro Inhibitors

Maowa J, Hosen M.A, Alam A, Rana KM, Fujii Y, Ozeki Y, SMA Kawsar

Physical Chemistry Research, 9(3) 385-412, Apr, 2021 Peer-reviewed
Synthesis, Characterization, and Molecular Docking Against a Receptor Protein FimH of Escherichia coli (4XO8) of Thymidine Derivatives

Asraful Alam, Mohammed Anowar Hosen, Anowar Hosen, Yuki Fujii, Yasuhiro Ozeki, Sarkar Mohammad Abe Kawsar

Journal of the Mexican Chemical Society, 65(2), Feb 22, 2021 Peer-reviewed
Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents

Md Z. H. Bulbul, Tasneem S. Chowdhury, Md M. H. Misbah, Jannatul Ferdous, Sujan Dey, Imtiaj Hasan, Yuki Fujii, Yasuhiro Ozeki, Sarkar M. A. Kawsar

Pharmacia, 68(1) 23-34, Jan 7, 2021 Peer-reviewed
In silico DFT study, molecular docking, and ADMET predictions of cytidine analogs with antimicrobial and anticancer properties.

Kazi M Rana, Jannatul Maowa, Asraful Alam, Sujan Dey, Anowar Hosen, Imtiaj Hasan, Yuki Fujii, Yasuhiro Ozeki, Sarkar M A Kawsar

In silico pharmacology, 9(1) 42-42, 2021
Synthesis, characterization, synergistic antimicrobial properties and molecular docking of sugar modified uridine derivatives

Jannatul Maowa, Asraful Alam, Kazi M. Rana, Sujan Dey, Anowar Hosen, Yuki Fujii, Imtiaj Hasan, Yasuhiro Ozeki, Sarkar M.A. Kawsar

Ovidius University Annals of Chemistry, 32(1) 6-21, Jan 1, 2021 Peer-reviewed
The structure of SeviL, a GM1b/asialo-GM1 binding R-type lectin from the mussel Mytilisepta virgata

Kenichi Kamata, Kenji Mizutani, Katsuya Takahashi, Roberta Marchetti, Alba Silipo, Christine Addy, Sam-Yong Park, Yuki Fujii, Hideaki Fujita, Tsuyoshi Konuma …

Scientific Reports, 10(1) 22102-22102, Dec 16, 2020 Peer-reviewed
119

Thermochemical, DFT, Molecular Docking and Pharmacokinetic Studies of Methyl β-D-galactopyranoside Esters

Sarkar M. A. Kawsar, Mohammed A. Hosen, Yuki Fujii, Yasuhiro Ozeki

SDRP Journal of Computational Chemistry & Molecular Modelling, 4(4) 452-462, Jul 15, 2020 Peer-reviewed
Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells.

Sugawara S, Takayanagi M, Honda S, Tatsuta T, Fujii Y, Ozeki Y, Ito J, Sato M, Hosono M

Glycobiology, 30(10) 802-816, Apr 5, 2020 Peer-reviewed
Purification and Functional Characterization of the Effects on Cell Signaling of Mytilectin: A Novel β-Trefoil Lectin from Marine Mussels

Yuki Fujii, S. M. Abe Kawsar, Imtiaj Hasan, Hideaki Fujita, Marco Gerdol, Yasuhiro Ozeki

Methods in Molecular Biology, 201-213, 2020
A GM1b/asialo-GM1 oligosaccharide-binding R-type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases.

Yuki Fujii, Marco Gerdol, Sarkar M A Kawsar, Imtiaj Hasan, Francesca Spazzali, Tatsusada Yoshida, Yukiko Ogawa, Sultana Rajia, Kenichi Kamata, Yasuhiro Koide …

The FEBS journal, 287(12) 2612-2630, Nov 26, 2019 Peer-reviewedLead authorCorresponding author
MytiLec-1 shows glycan-dependent toxicity against brine shrimp artemia and induces apoptotic death of Ehrlich ascites carcinoma cells In vivo.

Hasan I, Asaduzzaman AKM, Swarna RR, Fujii Y, Ozeki Y, Uddin MB, Kabir SR

Mar Drugs, 17(9) E502-502, Aug, 2019 Peer-reviewedInvited

Books and Other Publications

New Carbohydrate Derivatives: Synthesis, Characterization and Antimicrobial Screening Studies against Human and Plant Pathogens

Kawsar S.M.A., Fujii Y, Ozeki Y (Role: Joint author, Chapter 6 "Current Perspectives on Chemical Sciences Vol.3")

Book Publisher International, Nov, 2020
Lectin Purification and Analysis Methods and Protocols. Jun Hirabayashi ed

Fujii Y, Kawsar S.M.A, Hasan I, Fujita H, Gerdol M, Ozeki Y (Role: Joint author, Chapt 21. Purification and functional characterization of the effects on cell signaling of mytilectin: A novel β-trefoil lectin from marine mussels)

Humana Press (Springer US), Apr, 2020
“Marine Omics, Principles and Applications. Se-Kwon Kim ed” Chapter 21 SUEL/RBL-Lectins and their biomedical applications.

Koide Y, Hasan I, Fujii Y, Kawsar SMA, Rajia S, Sugawara S, Ogawa Y, Hosono M, Kanaly RA, Ozeki Y (Role: Joint author)

Taylor & Francis Group, CRC press, Aug, 2016
“Marine Glycobiology: Principles and Applications” Chapt 33. Structural glycobiology for lectin to promote advanced biomedical research.

Hasan I, Fujii Y, Rajia S, Kawsar SMA, Sugawara S, Ogawa Y, Hosono M, Koide Y, Kanaly RA, Ozeki Y (Role: Joint author)

Taylor & Francis Group, CRC press, 2016
“Marine Proteins and Peptides” edited by Se-Kwon Kim, Chapter10: Fascinating potential of diversified marine invertebrate lectins to decipher glycan-codes and control cell functions.

Ozeki Y, Kawsar SMA, Fujii Y, Ogawa Y, Sugawara S, Hasan I, Koide Y, Yasumitsu H, Kanaly RA (Role: Joint author)

Wiley & Blackwell Co. Ltd, Apr, 2013

Presentations

医学応用のためのβ-トレフォイルレクチンの基礎研究

YUKI FUJII

108th Indian Science Congress, Jan 5, 2023 Invited
Molecular tinkering and bricolage in mussel R-type lectins

YUKI FUJII

The 24th Collegium for Comparative Glycomics, Sep 3, 2022 Invited
糖は甘いだけじゃない！糖鎖が関わる病気と健康

藤井佑樹

ひらど市民大学（一般市民講座）, Jan 26, 2019
糖は甘いだけじゃない！糖鎖が関わる病気と健康

藤井佑樹

佐世保まちなか大学(一般市民講座), Dec 8, 2018

Teaching Experience

Sep, 2022 - Present

Community understanding and collaboration (Nagasaki International University)
Apr, 2020 - Present

機能形態学I (長崎国際大学薬学部薬学科)
Jun, 2018 - Aug, 2022

形態機能学 (佐世保市医師会看護専門学校)
薬剤学実習 (長崎国際大学薬学部薬学科)
機能形態学実習 (長崎国際大学薬学部薬学科)
薬学英語 (長崎国際大学薬学部薬学科)
基礎の生物学 (長崎国際大学健康管理学部健康栄養学科)
生物学演習 (長崎国際大学薬学部薬学科)

Professional Memberships

2019 - Present

日本生化学会
THE PHARMACEUTICAL SOCIETY OF JAPAN
THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH

Misc.

The molecular morphology of the cytotoxic retrotranslocation by an N-acetylhexosamine-binding lectin isolated from slipper lobster in breast and ovarian cancer cells

Yuki Fujii, Toshiyuki Fujiwara, Yukiko Ogawa, Shigeki Sugawara, Masahiro Hosono, Imtiaji Hasan, Yasuhiro Koide, S. M. A. Kawsar, Yasuhiro Ozeki, Hideaki Fujita

GLYCOBIOLOGY, 24(11) 1197-1198, Nov, 2014
Intracellular trafficking of MytiLec, a Gb3-specific R-type mussel lectin with cytotoxic activity

Imtiaj Hasan, Yuki Fujii, Yukiko Ogawa, Shigeki Sugawara, Masahiro Hosono, Yasuhiro Koide, Sultana Rajia, Sarkar M. A. Kawsar, Robert Kanaly, Toshiyuki Fujiwara …

GLYCOBIOLOGY, 24(11) 1131-1132, Nov, 2014
Alectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells (vol 287, pg 44772, 2012)

Yuki Fujii, Naoshi Dohmae, Koji Takio, Sarkar M. A. Kawsar, Ryo Matsumoto, Imtiaj Hasan, Yasuhiro Koide, Robert A. Kanaly, Hidetaro Yasumitsu, Yukiko Ogawa …

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(9) 6588-6588, Mar, 2013