Yasushi Fujio

Profile Information

Affiliation: Osaka University

Degree: 博士（医学）(大阪大学)

Other name(s) (e.g. nickname): Yasu
Researcher number: 20359839
J-GLOBAL ID: 201801002481071977
researchmap Member ID: B000328691

Research Areas

Papers

235

JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.

Hibiki Sakai, Hiroyasu Kamuro, Nagisa Tokunoh, Takeshi Izawa, Shigeyuki Tamiya, Ayaha Yamamoto, Shota Tanaka, Daisuke Okuzaki, Chikako Ono, Yoshiharu Matsuura …

American journal of physiology. Renal physiology, Apr 18, 2024
Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes.

Shota Suzuki, Shota Tanaka, Yusuke Kametani, Ayaka Umeda, Kosuke Nishinaka, Kaho Egawa, Yoshiaki Okada, Masanori Obana, Yasushi Fujio

Physiological reports, 11(23) e15872, Dec, 2023
Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

Maaya Morita, Aki Yoneda, Nagisa Tokunoh, Tatsumi Masaki, Keisuke Shirakura, Mayumi Kinoshita, Rina Hashimoto, Naoya Shigesada, Junya Takahashi, Masashi Tachibana …

Proceedings of the National Academy of Sciences of the United States of America, 120(3) e2213317120, Jan 17, 2023 Peer-reviewed
Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury.

Koki Tanaka, Hiroki Harada, Hiroyasu Kamuro, Hibiki Sakai, Ayaha Yamamoto, Masashi Tomimatsu, Akari Ikeda, Renya Chosokabe, Shota Tanaka, Yoshiaki Okada …

Biological & pharmaceutical bulletin, 46(12) 1753-1760, 2023
Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice.

Zhiqi Xie, Haoyang Zhou, Masanori Obana, Yasushi Fujio, Naoki Okada, Masashi Tachibana

Frontiers in immunology, 14 1243851-1243851, 2023
Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling

Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki …

Scientific Reports, 12(1), Dec, 2022 Peer-reviewedLast authorCorresponding author
Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis

Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Shunsuke Noda, Koki Tanaka, Hibiki Sakai, Narihito Tatsumoto, Chihiro Makino, Soshi Kanemoto, Go Shioi …

Communications Biology, 5(1) 734, Dec, 2022 Peer-reviewedLast author
Identification of biomarkers of chronic kidney disease among kidney-derived proteins

Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino …

Clinical Proteomics, 19(1) 3-3, Dec, 2022 Peer-reviewed
SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka …

Science advances, 8(38) eabo6783, Sep 23, 2022 Peer-reviewed
Safety evaluation of MA-T after ingestion in mice.

Takahiro Noguchi, Keisuke Tachibana, Tsuyoshi Inoue, Takayoshi Sakai, Kazutake Tsujikawa, Yasushi Fujio, Yoshiaki Yamagishi, Shigeto Hamaguchi, Satoshi Kutsuna, Masuo Kondoh

Toxicology, 477 153254-153254, Jul, 2022 Peer-reviewed
Glycoprotein 130 orchestrates signal transduction network to promote cardiomyocyte proliferation for normal growth

Masanori Obana, Makiko Maeda, Yasushi Fujio

American Journal of Physiology-Heart and Circulatory Physiology, 323(1) H125-H127, Jul 1, 2022 Peer-reviewedInvitedLast authorCorresponding author
CXCL10 is a novel anti-angiogenic factor downstream of p53 in cardiomyocytes.

Tri Wahyuni, Shota Tanaka, Ryuta Igarashi, Yoshiaki Miyake, Ayaha Yamamoto, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Shota Suzuki, Kosei Yokota …

Physiological reports, 10(9) e15304, May, 2022 Peer-reviewedLast author
Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study.

Hiroshi Akasaka, Ken Sugimoto, Ayumi Shintani, Satsuki Taniuchi, Koichi Yamamoto, Katsuomi Iwakura, Atsunori Okamura, Shin Takiuchi, Masahiro Fukuda, Kei Kamide …

Geriatrics & gerontology international, 22(4) 298-304, Apr, 2022 Peer-reviewed
Yes‐associated protein activation potentiates glycogen synthase kinase‐3 inhibitor‐induced proliferation of neonatal cardiomyocytes and iPS cell‐derived cardiomyocytes

Yusuke Kametani, Shota Tanaka, Yuriko Wada, Shota Suzuki, Ayaka Umeda, Kosuke Nishinaka, Yoshiaki Okada, Makiko Maeda, Shigeru Miyagawa, Yoshiki Sawa …

Journal of Cellular Physiology, 237(5) 2539-2549, Mar 21, 2022 Peer-reviewedLast authorCorresponding author
血管安定化分子Robo4の発現を変化させ血管透過性を制御する低分子化合物の探索

岡田欣晃, 木下真由美, 白倉圭佑, 樫尾泰斗, 村岡康介, 藤尾慈, 土井健史

日本内分泌学会雑誌, 97(5) 1519-1519, Mar, 2022
Claudinopathyの基盤研究 Clauidin-5と肺疾患

若山英里香, 橘敬祐, 橋本洋祐, 平山龍一, 谷里奈, 國安弘基, 竹田浩之, 岡田欣晃, 藤尾慈, 近藤昌夫

日本薬学会年会要旨集, 142年会 28PO2-02S, Mar, 2022
血管透過性を標的とする新戦略での疾患治療血管透過性を標的とする新戦略での重症感染症・炎症疾患治療薬の開発

岡田欣晃, 土井健史, 藤尾慈

日本薬学会年会要旨集, 142年会 S23-1, Mar, 2022
多様な臓器から考える線維化治療への最先端アプローチ線維症治療に資する線維芽細胞の血管内皮細胞への転換技術の開発

神原知明, 井澤洸栄, 土井健史, 藤尾慈, 岡田欣晃

日本薬学会年会要旨集, 142年会 GS02-4, Mar, 2022
Increased OASIS in podocytes contributes to the disruption of kidney homeostasis

Miyake Yoshiaki, Obana Masanori, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Imaizumi Kazunori, Asanuma Katsuhiko, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-YIA-23, 2022 Peer-reviewedLast author
IL-6 family cytokines, STAT3 activators, exhibit differential effects in a ligand-specific manner in podocytes

Sayuri Mitsuoka, Obana Masanori, Miyake Yoshiaki, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-O-010, 2022 Peer-reviewedLast author

Misc.

166

Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells.

Ying Lin, Kazuma Higashisaka, Takuya Shintani, Ayaka Maki, Sachiyo Hanamuro, Yuya Haga, Shinichiro Maeda, Hirofumi Tsujino, Kazuya Nagano, Yasushi Fujio …

Scientific reports, 10(1) 4748-4748, Mar 16, 2020 Peer-reviewed
Suppression of transcription factor OASIS ameliorated kidney fibrosis.

Masanori Obana, Ayaha Yamamoto, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Sayuri Mitsuoka, Shunsuke Noda, Makiko Maeda, Kazunori Imaizumi, Kotaro Matsumoto …

ASN Kidney Week 2019 Annual Meeting, Nov, 2019 Peer-reviewed
Blockade of NKG2D / NKG2D Ligand Interaction Attenuated Post-Infarct Myocardial Injury.

Kotaro Matsumoto, Masanori Obana, Arisa Kobayashi, Miho Kihara, Go Shioi, Shigeru Miyagawa, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yoshiki Sawa …

CIRCULATION, 138, Nov, 2018 Peer-reviewedCorresponding author
日本におけるPharm D.制度の推進 Pharm D(大阪大学)コース臨床科学に貢献するPharmacist-Scientistの育成を目指して

藤尾慈, 前田真一郎, 宇野公之

日本薬剤学会年会講演要旨集, 32年会 78-78, May, 2017
Heterozygous Ablation of ROR gamma t Gene Deteriorates Adverse Cardiac Remodeling After Myocardial Infarction

Daichi Enomoto, Masanori Obana, Kotaro Matsumoto, Yasushi Sakata, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION, 134, Nov, 2016 Peer-reviewed
Adult Mammalian Hearts Restore Intrinsic Regenerative Capacity Through Signal Transducer and Activation of Transcription 3 in the Resolution Phase of Myocarditis

Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-ichiro Fukada, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama …

CIRCULATION, 134, Nov, 2016 Peer-reviewed
急性心筋梗塞に対するIL-11製剤オプレルベキンを用いた心筋保護治療

野元陽太, 仲川将志, 泉康雄, 能仁信一, 阪本勇也, 水谷一輝, 白井伸幸, 杉岡憲一, 高木雅彦, 小和田康子 …

日本心臓病学会学術集会抄録, 64回 P-054, Sep, 2016 Peer-reviewed
Myeloid Cell Derived Leucine Rich alpha 2 Glycoprotein Attenuates Adverse Cardiac Remodeling After Myocardial Infarction

Shohei Kumagai, Hiroyuki Nakayama, Minoru Fujimoto, Hiromi Honda, Satoshi Serada, Atsushi Kasai, Masanori Obana, Yasushi Sakata, Yoshiki Sawa, Tetsuji Naka …

CIRCULATION, 132, Nov, 2015 Peer-reviewed
Cardiac STAT3 Activation in Subacute Phase of Myocardial Infarction was Required for the Suppression of Adverse Cardiac Remodeling

Daichi Enomoto, Masanori Obana, Akimitsu Miyawaki, Tomomi Mohri, Makio Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION, 132, Nov, 2015 Peer-reviewed
ドラッグ・リポジショニング研究と臨床薬理学血小板減少症治療薬IL-11から心筋保護薬IL-11へドラッグ・リポジショニングにおけるアカデミアのこころ

前田真貴子, 藤尾慈, 大和田康子, 藤井比佐子, 大門貴志, 中谷大作, 朝倉正紀, 泉康雄, 葭山稔

臨床薬理, 46(Suppl.) S105-S105, Nov, 2015 Peer-reviewed
Caveolae-Specific Phosphorylation of L-type Calcium Channel beta 2a Subunit Exacerbates Cardiac Hypertrophy

Shohei Kumagai, Nao Hayamizu, Sachi Matsunami, Wataru Otsuka, Yasushi Sakata, Yasushi Fujio, Hiroyuki Nakayama

CIRCULATION, 130, Nov, 2014
Vascular functional and morphological alterations in smokers with varenicline therapy

M. Kobayashi, Y. Takemoto, T. Shuto, N. Norioka, T. Iguchi, M. Maeda, Y. Fujio, J. Azuma, M. Yoshiyama, K. Hirohashi

EUROPEAN HEART JOURNAL, 35 902-903, Sep, 2014
創薬研究のパラダイムシフト―難治性疾患の分子創薬―循環器疾患における新規サイトカイン治療

大和田康子, 前田真貴子, 藤尾慈

臨床化学, 43(3) 191-196, Jul 31, 2014
Phosphorylation of L-type Ca2+ channel beta 2a subunit induces cardiomyocyte hypertrophy

Nao Hayamizu, Shohei Kumagai, Sachi Matsunami, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 134P-134P, 2014
Excessive BIN1 expression results in adverse remodeling through cardiomyocyte death

Kota Tonegawa, Sachi Matsunami, Daisuke Tsuchiyama, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 87P-87P, 2014
The macrophage-specific overexpression of CD93 enhances phagocytosis and ameliorates cardiac fibrosis after myocardial infarction

Kana Takewaki, Tomomi Yamashita, Kaori Miyamoto, Tomomi Mohri, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 87P-87P, 2014
心筋梗塞慢性期における心筋特異的STAT3の欠損は心筋リモデリングを悪化させる

榎本大智, 尾花理徳, 宮脇昭光, 毛利友美, 前田真貴子, 中山博之, 藤尾慈

生体機能と創薬シンポジウム要旨集, 2014 115, 2014
ニコチン代謝酵素CYP2A6遺伝子多型と呼気CO濃度の関係

前田真貴子, 杉浦知佳, 志賀遼太, 松岡翔太, 竹ノ内拓也, 中西和親, 山川剛, 藤尾慈, 東純一

臨床薬理, 44(Supplement) S256-S256, Nov 14, 2013
急性心筋梗塞に対するインターロイキン11(IL-11)製剤を用いた心筋保護治療の臨床試験のためのプロトコール作成研究

大和田康子, 泉康雄, 朝倉正紀, 山本晴子, 前田真貴子, 葭山稔, 藤尾慈

臨床薬理, 44(Suppl.) S248-S248, Nov, 2013
【循環器疾患とカルシウム・リン】 Ca2+依存性の心肥大・心筋細胞死誘導シグナル

中山博之, 山口修, 藤尾慈

Clinical Calcium, 23(4) 505-515, Mar, 2013

Professional Memberships

Research Projects

抗凝固薬の有効性及び安全性の予測モデル構築のための基盤研究～社会実装を目指して

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

前田真貴子, 藤尾慈
血管を経由する新発想での臓器の脱線維化技術の開発

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

岡田欣晃, 藤尾慈, 櫻井文教, 立花雅史
ゲノム薬理学を応用した国際共同臨床研究推進のための基盤構築

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2023

前田真貴子, 藤尾慈
Identification and characterization of novel myeloid cells that infiltrate into post-infarct myocardium

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Fujio Yasushi
Molecular mechanisms of cell proliferation of adult mammalian cardiomyocytes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Fujio Yasushi
Characterization of diploid cardiomyocytes in adult mammalian hearts

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

Fujio Yasushi
Study of Cardioprotective Signal through STAT3/Pim Kinase

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Makiko Maeda
The effect of interleukin-11 in a donation after circulatory death heart model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

KOUNO Hiroki
The role of leucine-rich alpha2 glycoprotein in cardiac remodeling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Nakayama Hiroyuki
The molecular and cellular mechanism of myocardial repair/regeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

FUJIO Yasushi
Novel anti-sepsis strategy targeting the endothelial cell-specific receptor Robo4

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Okada Yoshiaki, FUJIO Yasushi, KURODA Etsushi, Aird William
Immune surveillance is involved in cardiomyocyte death in diseased hearts

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

FUJIO Yasushi
Role of thrombospondin and nicotine dependence in vascular damage from smoking

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

TAKEMOTO Yasuhiko, YOSHIYAMA Minoru, HIROHASHI Kazuhiro, AZUMA Jyunichi, FUJIO Yasushi, MAEDA Makiko, NONEN Shinpei
Regulation of L-type calcium channel by intracellular subunit in cardiac hypertrophy and failure.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

NAKAYAMA HIROYUKI, ASAHI Michio, FUJIO Yasushi
Myocardial inflammation of heart failure as a novel therapeutic target

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

FUJIO Yasushi, NAKAYAMA Hiroyuki, NAKAOKA Yoshikazu
The Cardioprotective Effect Of Interleukin-11 in Cardiac Surgery

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

KOUNO Hiroki, MATSUMIYA Goro, ISHIZAKA Toru, ISHIDA Keiichi, FUJIO Yasushi
The study for the effects of Interluekin-11 on cardiac remodeling following recanalization therapy against myocardial infarction.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MAEDA Makiko, AZUMA Junichi, FUJIO Yasushi
Role and mechanism of thrombospondin in response to beta blocker therapy in patients with congestive heart failure

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

TAKEMOTO Yasuhiko, YOSHIYAMA Minoru, AZUMA Jyunichi, FUJIO Yasushi, MAEDA Makiko
Dynamics of cardiac stem cells in myocardial repair/regeneration and regulation of their cell fate by cytokines

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

FUJIO Yasushi, AZUMA Junichi, MAEDA Makiko
Advancing a critical clinical research to realize personalized medicine of tuberculosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

AZUMA\ Junichi, OHNO Masako, UWE FUHR

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