2017年10月
Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats
NEUROSCIENCE RESEARCH
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- 巻
- 123
- 号
- 開始ページ
- 27
- 終了ページ
- 35
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neures.2017.04.012
- 出版者・発行元
- ELSEVIER IRELAND LTD
The open field test is one of the most popular ethological tests to assess anxiety-like behavior in rodents. In the present study, we examined the effect of early deprivation (ED), a model of early life stress, on anxiety-like behavior in rats. In ED animals, we failed to find significant changes in the time spent in the center or thigmotaxis area of the open field, the common indexes of anxiety-like behavior. However, we found a significant increase in high-leaning behavior in which animals lean against the wall standing on their hindlimbs while touching the wall with their forepaws at a high position. The high-leaning behavior was decreased by treatment with an anxiolytic, diazepam, and it was increased under intense illumination as observed in the center activity. In addition, we compared the high-leaning behavior and center activity under various illumination intensities and found that the high-leaning behavior is more sensitive to illumination intensity than the center activity in the particular illumination range. These results suggest that the high-leaning behavior is a novel anxiety-like behavior in the open field test that can complement the center activity to assess the anxiety state of rats. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neures.2017.04.012
- ISSN : 0168-0102
- eISSN : 1872-8111
- PubMed ID : 28450152
- Web of Science ID : WOS:000413123300004