Hirota Yasushi

Profile Information

Affiliation: Professor, Department of Obstetrics and Gynecology, The University of Tokyo

Degree: MD, PhD(2005, The University of Tokyo)

J-GLOBAL ID: 201201078692197472
researchmap Member ID: B000219967

External link: https://plaza.umin.ac.jp/tkyobgyn/recruit/laboratory/hirota.html

Research Interests

Research Areas

Research History

2023 - Present

Professor, Department of Obstetrics & Gynecology, Graduate School of Medicine, The University of Tokyo
2020 - 2023

Associate Professor, Department of Obstetrics & Gynecology, Graduate School of Medicine, The University of Tokyo
2014 - 2020

Lecturer, Department of Obstetrics & Gynecology, The University of Tokyo
2011 - 2014

PRESTO Researcher, Japan Science and Technology Agency (JST)
2008 - 2010

Research Fellow for Research Abroad, Japan Society for the Promotion of Science, Cincinnati Childrens Hospital Medical Center
2007 - 2008

Japan Society for the Promotion of Science, Vanderbilt University Medical Center

Education

- 2005

Graduate School of Medicine, The University of Tokyo
- 1998

School of Medicine, The University of Tokyo

Committee Memberships

Awards

Dec, 2022

Kanzawa Medical Research Foundation Medical Award

Yasushi Hirota
Nov, 2017

Japan Medical Association Medical Research Encouragement Prize

Yasushi Hirota
Apr, 2017

The Japan Endocrine Society Research Award

Yasushi Hirota
Jul, 2013

The Japanese Society of Inflammation and Regeneration Research Award

Yasushi Hirota
Apr, 2009

Japan Society of Obstetrics and Gynecology Research Award

Yasushi Hirota
Nov, 2007

Japan Society of Reproductive Medicine Research Award

Yasushi Hirota

Major Papers

Pregnancy is associated with reduced progression of symptomatic adenomyosis: a retrospective pilot study

Daiki Hiratsuka, Erika Omura, Chihiro Ishizawa, Rei Iida, Yamato Fukui, Takehiro Hiraoka, Shun Akaeda, Mitsunori Matsuo, Miyuki Harada, Osamu Wada-Hiraike …

BMC Pregnancy Childbirth, 23(1) 634-634, Sep 4, 2023 Peer-reviewedLast authorCorresponding author
Current perspectives on endometrial receptivity: A comprehensive overview of etiology and treatment.

Takehiro Hiraoka, Yutaka Osuga, Yasushi Hirota

J Obstet Gynaecol Res, Aug 1, 2023 Peer-reviewedInvitedLast author
The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion.

Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Akihiko Sakashita, Ryoko Shimizu-Hirota, Norihiko Takeda, Chihiro Ishizawa, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata …

Cell Death Dis, 14(5) 320-320, May 18, 2023 Peer-reviewedCorresponding author
Levonorgestrel-Releasing Intrauterine System Improves Menorrhagia-Related Quality of Life in Patients with Symptomatic Adenomyosis.

Chihiro Ishizawa, Yasushi Hirota, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, Yamato Fukui, Erika Omura, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo …

Reprod Sci, 30(3) 966-973, Mar, 2023 Peer-reviewedCorresponding author
How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights

Takehiro Hiraoka, Yasushi Hirota, Yutaka Osuga

F&S Reviews, 4(1) 15-25, Jan, 2023 Peer-reviewed
DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice

Daiki Hiratsuka, Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga

Reproductive Sciences, 30(2) 494-525, May 31, 2022 Peer-reviewedCorresponding author
Constant activation of STAT3 contributes to the development of adenomyosis in females

Takehiro Hiraoka, Yasushi Hirota, Shizu Aikawa, Rei Iida, Chihiro Ishizawa, Tetsuaki Kaku, Tomoyuki Hirata, Yamato Fukui, Shun Akaeda, Mitsunori Matsuo …

Endocrinology, 163(5) bqac044, Apr 4, 2022 Peer-reviewedCorresponding author
Guidelines for Reproductive Medicine in Japan

Mitsutoshi Yamada, Tomonori Ishikawa, Takeshi Iwasa, Hajime Oishi, Satoko Osuka, Kenji Oka, Shuichi Ono, Masanori Ono, Makoto Orisaka, Haruhiko Kanasaki …

Reproductive Medicine and Biology, 21(1) e12483, Jan, 2022 Peer-reviewed
A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Chihiro Ishizawa, Rei IIda, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo …

Reprod Med Biol, 21(1) e12435, Jan, 2022 Peer-reviewedCorresponding author
Uterine Receptivity is Reflected by LIF Expression in the Cervix

Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Chihiro Ishizawa, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo …

Reprod Sci, 29(5) 1457-1462, Dec 2, 2021 Peer-reviewedCorresponding author
Uterine epithelial LIF receptors contribute to implantation chamber formation in blastocyst attachment

Yamato Fukui, Yasushi Hirota, Tomoko Saito-Fujita, Shizu Aikawa, Takehiro Hiraoka, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Mitsunori Matsuo, Ryoko Shimizu-Hirota …

Endocrinology, 162(11) bqab169, Aug 17, 2021 Peer-reviewedCorresponding author
Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion

Shun Akaeda, Yasushi Hirota, Yamato Fukui, Shizu Aikawa, Ryoko Shimizu-Hirota, Tetsuaki Kaku, Mona Gebril, Tomoyuki Hirata, Takehiro Hiraoka, Mitsunori Matsuo …

EMBO Rep, 22(2) e50927, Feb 3, 2021 Peer-reviewedCorresponding author
Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation

Mona Gebril, Yasushi Hirota, Shizu Aikawa, Yamato Fukui, Tetsuaki Kaku, Mitsunori Matsuo, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Ryoko Shimizu-Hirota …

Endocrinology, 161(12) bqaa195, Dec 1, 2020 Peer-reviewedCorresponding author
Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment

Takehiro Hiraoka, Yasushi Hirota, Yamato Fukui, Mona Gebril, Tetsuaki Kaku, Shizu Aikawa, Tomoyuki Hirata, Shun Akaeda, Mitsunori Matsuo, Hirofumi Haraguchi …

Sci Rep, 10(1) 15523, Sep 23, 2020 Peer-reviewedCorresponding author
KRAS mutations in uterine endometrium are associated with gravidity and parity

Satoshi Inoue, Emiko Yoshida, Yamato Fukui, Toshihide Ueno, Masahito Kawazu, Reina Takeyama, Masako Ikemura, Yutaka Osuga, Yasuhisa Terao, Yasushi Hirota …

Cell Death Dis, 11(5) 347, May 11, 2020 Peer-reviewed
Medical and surgical treatment for adenomyosis

Yasushi Hirota

72(4) 591-595, Apr, 2020 InvitedCorresponding author
Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor

Mitsunori Matsuo, Yasushi Hirota, Yamato Fukui, Hidetoshi Fujita, Tomoko Saito-Fujita, Tetsuaki Kaku, Mona Gebril, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka …

Endocrinology, 161(2) bqz005, Feb 1, 2020 Peer-reviewedCorresponding author
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations

Satoshi Inoue, Yasushi Hirota, Toshihide Ueno, Yamato Fukui, Emiko Yoshida, Takuo Hayashi, Shinya Kojima, Reina Takeyama, Taiki Hashimoto, Tohru Kiyono …

Nat Commun, 10(1) 5785-5785, Dec 19, 2019 Peer-reviewed
Outcome of conservative surgery for symptomatic adenomyosis

Kaku T, Hirota Y, Fukui Y, Omura E, Akaeda S, Hiraoka T, Matsuo M, Haraguchi H, Osuga Y, Fujii T

Obstet Gynecol, 86(6) 767-771, Jun, 2019 Peer-reviewedCorresponding author
Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation

Fukui Y, Hirota Y, Matsuo M, Gebril M, Akaeda S, Hiraoka T, Osuga Y

Reprod Med Biol, 18(3) 234-240, May, 2019 Peer-reviewedInvitedCorresponding author
Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention.

Deng W, Yuan J, Cha J, Sun X, Bartos A, Yagita H, Hirota Y, Dey SK

Cell Rep, 27(6) 1755-1768, May, 2019 Peer-reviewed
Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation.

Hirota Y

Endocr J, 66(3) 199-206, Mar, 2019 Peer-reviewedInvitedCorresponding author
Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality

Hirofumi Haraguchi, Yasushi Hirota, Tomoko Saito-Fujita, Tomoki Tanaka, Ryoko Shimizu-Hirota, Miyuki Harada, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Leona Matsumoto …

FASEB J, 33(2) 2610-2620, Feb, 2019 Peer-reviewedCorresponding author
Adenomyosis: Current treatment and future tasks

Hirota Y

Acta Obstetrica et Gynaecologica Japonica, 70(11) 2377-2380, Nov, 2018 InvitedCorresponding author
HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment.

Leona Matsumoto, Yasushi Hirota, Tomoko Saito-Fujita, Norihiko Takeda, Tomoki Tanaka, Takehiro Hiraoka, Shun Akaeda, Hidetoshi Fujita, Ryoko Shimizu-Hirota, Shota Igaue …

The Journal of Clinical Investigation, 128(7) 3186-3197, Jul 2, 2018 Peer-reviewedLead authorCorresponding author
F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus

Mahiro Egashira, Yasushi Hirota, Ryoko Shimizu-Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Leona Matsumoto, Mitsunori Matsuo, Takehiro Hiraoka, Tomoki Tanaka, Shun Akaeda …

Endocrinology, 158(7) 2344-2353, Jul, 2017 Peer-reviewedCorresponding author
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways

Shizu Aikawa, Kuniyuki Kano, Asuka Inoue, Jiao Wang, Daisuke Saigusa, Takeshi Nagamatsu, Yasushi Hirota, Tomoyuki Fujii, Soken Tsuchiya, Yoshitaka Taketomi …

EMBO J, 36(14) 2146-2160, Jul, 2017 Peer-reviewed
Clinical feature of uterine adenomyosis patients developing deep venous thrombosis

Ohmura E, Hirota Y, Osuga Y, Fujii T

Obstet Gynecol (Tokyo), 84(6) 740-745, Jun, 2017 Peer-reviewedCorresponding author
Diagnostic imaging: Uterine fibroid and adenomyosis

Hirota Y, Osuga Y

Clin Gynecol Obstet, 71(4) 233-238, Apr, 2017 InvitedCorresponding author
Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility

Alan D. Bolnick, Jay M. Bolnick, Brian A. Kilburn, Tamika Stewart, Jonathan Oakes, Javier Rodriguez-Kovacs, Hamid-Reza Kohan-Ghadr, Jing Dai, Michael P. Diamond, Yasushi Hirota …

Hum Reprod, 31(9) 2042-2050, Sep, 2016 Peer-reviewed
p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

Wenbo Deng, Jeeyeon Cha, Jia Yuan, Hirofumi Haraguchi, Amanda Bartos, Emma Leishman, Benoit Viollet, Heather B. Bradshaw, Yasushi Hirota, Sudhansu K. Dey

J Clin Invest, 126(8) 2941-2954, Aug, 2016 Peer-reviewed
STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation.

Hiraoka T, Hirota Y, Saito-Fujita T, Matsuo M, Egashira M, Matsumoto L, Haraguchi H, Dey SK, Furukawa KS, Fujii T …

JCI insight, 1(8) e87591, Jun, 2016 Peer-reviewedCorresponding author
Species difference in embryo implantation

Egashira M, Hirota Y

Horm Front Gynecol, 22(3) 183-189, Sep, 2015 InvitedCorresponding author
MSX Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus

Jeeyeon Cha, Kristin E. Burnum-Johnson, Amanda Bartos, Yingju Li, Erin S. Baker, Susan C. Tilton, Bobbie-Jo M. Webb-Robertson, Paul D. Piehowski, Matthew E. Monroe, Anil G. Jegga …

J Biol Chem, 290(24) 15337-15349, Jun, 2015 Peer-reviewed
Severe adhesion at the Douglas pouch in endometriosis patients with chronic pelvic pain

Hirota Y

Clin Gynecol Obstet, 69(5) 465-470, May, 2015 Peer-reviewedLead authorCorresponding author
How does progesterone support embryo implantation?

Takehiro Hiraoka, Tomoko Saito-Fujita, Yasushi Hirota

J Mamm Ova Res, 32(3) 87-94, 2015 Peer-reviewedInvitedCorresponding author
MicroRNA-200a Locally Attenuates Progesterone Signaling in the Cervix, Preventing Embryo Implantation

Hirofumi Haraguchi, Tomoko Saito-Fujita, Yasushi Hirota, Mahiro Egashira, Leona Matsumoto, Mitsunori Matsuo, Takehiro Hiraoka, Kaori Koga, Naoko Yamauchi, Masashi Fukayama …

Mol Endocrinol, 28(7) 1108-1117, Jul, 2014 Peer-reviewedCorresponding author
Application of Detergents or High Hydrostatic Pressure as Decellularization Processes in Uterine Tissues and Their Subsequent Effects on In Vivo Uterine Regeneration in Murine Models

Erna G. Santoso, Keita Yoshida, Yasushi Hirota, Masanori Aizawa, Osamu Yoshino, Akio Kishida, Yutaka Osuga, Shigeru Saito, Takashi Ushida, Katsuko S. Furukawa

PLoS One, 9(7) e103201, Jul, 2014 Peer-reviewed
Endometrial cellular senescence contributes to preterm birth

Yasushi Hirota

Inflamm Regen, 34(1) 64-68, 2014 Peer-reviewedInvitedCorresponding author
Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions

Jeeyeon Cha, Amanda Bartos, Mahiro Egashira, Hirofumi Haraguchi, Tomoko Saito-Fujita, Emma Leishman, Heather Bradshaw, Sudhansu K. Dey, Yasushi Hirota

J Clin Invest, 123(9) 4063-4075, Sep, 2013 Peer-reviewedLast authorCorresponding author
Uterine receptivity and embryo-uterine interactions in embryo implantation: Lessons from mice

Mahiro Egashira, Yasushi Hirota

Reprod Med Biol, 12(4) 127-132, 2013 Peer-reviewedInvitedCorresponding author
Estrogen-Dependent Uterine Secretion of Osteopontin Activates Blastocyst Adhesion Competence

Takashi Chaen, Toshihiro Konno, Mahiro Egashira, Rulan Bai, Nana Nomura, Shintaro Nomura, Yasushi Hirota, Toshihiro Sakurai, Kazuhiko Imakawa

PLoS One, 7(11) e48933, Nov, 2012 Peer-reviewed
Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua

Kristin E. Burnum, Yasushi Hirota, Erin S. Baker, Mikihiro Yoshie, Yehia M. Ibrahim, Matthew E. Monroe, Gordon A. Anderson, Richard D. Smith, Takiko Daikoku, Sudhansu K. Dey

Endocrinology, 153(9) 4568-4579, Sep, 2012 Peer-reviewedLead author
Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52

Yasushi Hirota, Kristin E. Burnum, Nuray Acar, Gabriel A. Rabinovich, Takiko Daikoku, Sudhansu K. Dey

Endocrinology, 153(5) 2486-2493, May, 2012 Peer-reviewedLead author
Sensing senescence in preterm birth

Jeeyeon Cha, Yasushi Hirota, Sudhansu K. Dey

Cell Cycle, 11(2) 205-206, Jan, 2012 Peer-reviewed
Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity

Takiko Daikoku, Jeeyeon Cha, Xiaofei Sun, Susanne Tranguch, Huirong Xie, Tomoko Fujita, Yasushi Hirota, John Lydon, Francesco DeMayo, Robert Maxson …

Dev Cell, 21(6) 1014-1025, Dec, 2011 Peer-reviewed
Heightened uterine mTORC1 signaling provokes preterm birth in mice

Yasushi Hirota, Jeeyeon Cha, Mikihiro Yoshie, Takiko Daikoku, Sudhansu K. Dey

Proc Natl Acad Sci U S A, 108(44) 18073-18078, Nov, 2011 Peer-reviewedLead author
Uterine FKBP52-PRDX6 signaling protects pregnancy from overt oxidative stress

Yasushi Hirota, Nuray Acar, Susanne Tranguch, Kristin E. Burnum, Huirong Xie, Ako Kodama, Yutaka Osuga, Ismail Ustunel, David B. Friedman, Richard M. Caprioli …

Proc Natl Acad Sci U S A, 107(35) 15577-15582, Aug, 2010 Peer-reviewedLead author
Prematurity and the puzzle of progesterone resistance

Yasushi Hirota, Jeeyeon Cha, Sudhansu K. Dey

Nat Med, 16(5) 529-531, May, 2010 Peer-reviewedLead author
Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

Yasushi Hirota, Takiko Daikoku, Susanne Tranguch, Huirong Xie, Heather B. Bradshaw, Sudhansu K. Dey

J Clin Invest, 120(3) 803-815, Mar, 2010 Peer-reviewedLead author

Teaching Experience

- Present

Obstetrics and Gynecology (The University of Tokyo)

Media Coverage

[Press Release] Endometrial epigenetic abnormalities cause implantation failure

NHK news, https://www3.nhk.or.jp/news/html/20230527/k10014079801000.html, May 27, 2023 TV or radio program
[Press release] Sustained cell proliferation in the endometrial epithelium causes implantation failure -Elucidation of the mechanism of implantation by progesterone-

https://www.h.u-tokyo.ac.jp/press/20210105-2.html, Jan 5, 2021 Other
[Press Release] Genomic Analysis of Adenomyosis Discovers Genetic Mutations Associated with Onset and Concomitant Endometriosis -Expectations for Elucidation of Onset Mechanism-

https://www.ncc.go.jp/jp/information/pr_release/2019/1219/index.html, Dec 19, 2019 Other
[Press Release] Elucidation of the Implantation Mechanism of Embryo Infiltration into the Endometrial -Effects of HIF2α, a Hypoxia-Inducible Factor in the Endometrial that Enables Embryo Invasion-

https://www.h.u-tokyo.ac.jp/press/20180619.html, Jun 19, 2018 Other
[Press Release] Mechanism of endometrial remodeling and uterine regeneration mediated by the transcription factor STAT3

https://www.h.u-tokyo.ac.jp/press/20160603-1.html, Jun 3, 2016 Other
[Press release] Discovery of a mechanism that causes premature birth due to interaction between maternal constitution and infection/inflammation - A new clue to premature birth prevention -

https://www.jst.go.jp/pr/info/info977/, Aug 28, 2013 Other

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