Yukiko U. Inoue

Profile Information

Affiliation: National Institute of Neuroscience,Ncnp, National Center of Neurology and Psychiatry

Degree: 博士（薬学）(京都薬科大学)

Other name(s) (e.g. nickname): 上野由紀子
Researcher number: 30611777
ORCID ID: https://orcid.org/0000-0002-4105-9127
J-GLOBAL ID: 201401073522031262
researchmap Member ID: B000238000

External link: https://www.ncnp.go.jp/nin/guide/r6/

Research Areas

Research History

Apr, 2020 - Present

Research Fellow, National Center of Neurology and Psychiatry
Apr, 2015 - Present

National Center of Neurology and Psychiatry
2012

National Center of Neurology and Psychiatry

Awards

Nov, 2019

第４回若手の会・技術講習会ベストポスター賞, 新学術領域「個性」創発脳

井上(上野)由紀子
Mar, 2017

第38回神経研究所研究発表会最優秀ポスター発表賞, クローニング不要CRISPR/Cas9法・受精卵エレクトロポレーションによる病態モデルノックインマウスの作製, 国立精神・神経医療研究センター神経研究所

井上(上野)由紀子、星野幹雄、井上高良
Sep, 2015

JNS-CNS Travel Award Program 2015, Ultra-rapid generation of genome-edited mice crucial for neurodevelopmental research via CRISPR/Cas9

Yukiko U. Inoue
Mar, 2015

第36回神経研究所研究発表会最優秀ポスター発表賞, CRISPR/Cas9ゲノム編集技術による簡便・迅速な遺伝子改変マウスの作出, 国立精神・神経医療研究センター神経研究所

井上(上野)由紀子、井上高良

Major Papers

Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation

Ken-ichi Dewa, Nariko Arimura, Wataru Kakegawa, Masayuki Itoh, Toma Adachi, Satoshi Miyashita, Yukiko U. Inoue, Kento Hizawa, Kei Hori, Natsumi Honjoya …

Nature Communications, 15(1), Feb 1, 2024 Peer-reviewed
Visualization of trans homophilic interaction of clustered protocadherin in neurons.

Natsumi Hoshino, Takashi Kanadome, Tomomi Takasugi, Mizuho Itoh, Ryosuke Kaneko, Yukiko U Inoue, Takayoshi Inoue, Takahiro Hirabayashi, Masahiko Watanabe, Tomoki Matsuda …

Proceedings of the National Academy of Sciences of the United States of America, 120(38) e2301003120, Sep 19, 2023 Peer-reviewed
Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

Daiki X. Sato, Yukiko U. Inoue, Nahoko Kuga, Satoko Hattori, Kensaku Nomoto, Yuki Morimoto, Giovanni Sala, Hideo Hagihara, Takefumi Kikusui, Takuya Sasaki …

iScience, 25(8) 104800-104800, Aug, 2022 Peer-reviewedLead author
Targeting Neurons with Functional Oxytocin Receptors: A Novel Set of Simple Knock-In Mouse Lines for Oxytocin Receptor Visualization and Manipulation

Yukiko U. Inoue, Hideki Miwa, Kei Hori, Ryosuke Kaneko, Yuki Morimoto, Eriko Koike, Junko Asami, Satoshi Kamijo, Mitsuhiko Yamada, Mikio Hoshino …

eNeuro, 9(1) ENEURO.0423-21.2022, Jan, 2022 Peer-reviewedLead authorCorresponding author
Detection of REST expression in the testis using epitope‐tag knock‐in mice generated by genome editing

Ryuichi Kimura, Yukiko U. Inoue, Takako Kikkawa, Misako Tatehana, Yuki Morimoto, Hitoshi Inada, Shinya Oki, Takayoshi Inoue, Noriko Osumi

Developmental Dynamics, 251(3) 525-535, Sep 20, 2021 Peer-reviewedLead author
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.

Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma …

Nature communications, 12(1) 4293-4293, Jul 13, 2021 Peer-reviewed
An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation.

Yukiko U Inoue, Yuki Morimoto, Mayumi Yamada, Ryosuke Kaneko, Kazumi Shimaoka, Shinji Oki, Mayuko Hotta, Junko Asami, Eriko Koike, Kei Hori …

Cells, 10(5), Apr 30, 2021 Peer-reviewedLead authorCorresponding author
Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness.

Kou Hiraga, Yukiko U Inoue, Junko Asami, Mayuko Hotta, Yuki Morimoto, Shoji Tatsumoto, Mikio Hoshino, Yasuhiro Go, Takayoshi Inoue

Communications biology, 3(1) 574-574, Oct 15, 2020 Peer-reviewed
DSCAM regulates delamination of neurons in the developing midbrain.

Nariko Arimura, Mako Okada, Shinichiro Taya, Ken-Ichi Dewa, Akiko Tsuzuki, Hirotomo Uetake, Satoshi Miyashita, Koichi Hashizume, Kazumi Shimaoka, Saki Egusa …

Science advances, 6(36), Sep, 2020 Peer-reviewed
Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping.

Yuko Hara, Yoshitaka Mizobe, Yukiko U Inoue, Yasumasa Hashimoto, Norio Motohashi, Yoshiaki Masaki, Kohji Seio, Shin'ichi Takeda, Tetsuya Nagata, Matthew J A Wood …

Scientific reports, 10(1) 10110-10110, Jun 22, 2020 Peer-reviewed
Generation of Pax6-IRES-EGFP knock-in mouse via the cloning-free CRISPR/Cas9 system to reliably visualize neurodevelopmental dynamics.

Yukiko U Inoue, Yuki Morimoto, Mikio Hoshino, Takayoshi Inoue

Neuroscience research, 132 1-7, Jul, 2018 Peer-reviewedLead authorCorresponding author
Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus.

Yukiko U Inoue, Takayoshi Inoue

Scientific reports, 6 31227-31227, Aug 9, 2016 Peer-reviewedLead authorCorresponding author
Genetic labeling of mouse rhombomeres by Cadherin-6::EGFP-BAC transgenesis underscores the role of cadherins in hindbrain compartmentalization.

Yukiko U Inoue, Junko Asami, Takayoshi Inoue

Neuroscience research, 63(1) 2-9, Jan, 2009 Peer-reviewedLead author
Cadherin-6 gene regulatory patterns in the postnatal mouse brain.

Yukiko U Inoue, Junko Asami, Takayoshi Inoue

Molecular and cellular neurosciences, 39(1) 95-104, Sep, 2008 Peer-reviewedLead author
Analysis of mouse Cdh6 gene regulation by transgenesis of modified bacterial artificial chromosomes.

Takayoshi Inoue, Yukiko U Inoue, Junko Asami, Hitomi Izumi, Shun Nakamura, Robb Krumlauf

Developmental biology, 315(2) 506-20, Mar 15, 2008 Peer-reviewed

Major Misc.

Humanized mouse models to decipher the diversity of nervous system

Yukiko U. Inoue, Yoneko Hayase, Mikio Hoshino, Daiki X. Sato, Masakado Kawata, Tetsushi Sakuma, Takashi Yamamoto, Takayoshi Inoue

The CELL, New animal models with genome editing, 708(Vol.53 No.7, 2021) 52(448)-56(452), Jun, 2021 InvitedLead authorCorresponding author
クローニングフリーCRISPR/Cas9法によるノックインマウス作製術

井上(上野)由紀子、森本由起、井上高良

生体の科学, 70(4) 350-356, Aug, 2019 InvitedLead authorCorresponding author

Presentations

ゲノム編集によるオキシトシン受容体発現細胞の可視化・操作ツールの開発

井上(上野)由紀子

東京慈恵会医科大学医学研究の基礎を語り合う集い第468回シリーズ・神経機能研究の最前線 No.65, Oct 27, 2021 Invited
CRISPR/Cas9ゲノム編集技術による遺伝子改変マウス作製支援

井上(上野)由紀子

新学術領域「個性」創発脳第４回若手の会・技術講習会, Nov 15, 2019 Invited
ゲノム編集技術を駆使したマウス脳でのオキシトシン受容体遺伝子発現の可視化・ヒト化

井上(上野)由紀子

玉川大学脳科学研究所若手の会, Oct 4, 2019 Invited
CRISPR/Cas9ゲノム編集技術による遺伝子改変マウスの作製

井上(上野)由紀子

新学術領域「個性」創発脳第３回若手の会・技術講習会, Nov 13, 2018 Invited
CRISPR/Cas9ゲノム編集技術による遺伝子改変マウスの作製

井上(上野)由紀子

新学術領域「個性」創発脳第２回若手の会・技術講習会, Nov 21, 2017 Invited
CRISPR/Cas9ゲノム編集技術による迅速な遺伝子改変マウスの作製法

井上(上野)由紀子

分子回路系神経科学セミナーシリーズ第６回, May 28, 2014 Invited

Professional Memberships

Research Projects

細胞内タンパク質局在を高解像度で可視化できるS/N比の良いゲノム編集マウスの開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

井上由紀子
Fine visualization of oxytocin receptor expressing neurons via the novel labeling system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
ヒト化マウス作製技術により明らかにする脳神経系発生発達多様性の分子的基盤

科学研究費補助金（新学術領域公募研究）, 文部科学省, Apr, 2019 - Mar, 2021

井上由紀子
ヒト化マウス作製技術により明らかにする脳神経系発生発達多様性の分子的基盤

科学研究費補助金（新学術領域公募研究）, 文部科学省, Apr, 2017 - Mar, 2019

井上由紀子
オキシトシン受容体遺伝子の脳領域特異的エンハンサー探索：自閉症関連SNPとの関係

科学研究費補助金（基盤研究(C)）, 文部科学省, Apr, 2016 - Mar, 2019

井上由紀子
Elucidation of cellular and molecular machinery to elaborate the barrel area specific cytoarchitecture in the mouse cerebral cortex

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2017

Inoue Takayoshi, INOUE YUKIKO, ASAMI JUNKO, TERAKAWA YOUHEI, EGUSA SAKI, HIRAGA KOU
Enhancer trap analysis for Autism Spectrum Disorder associated locus by utilizing Human BAC transgenic mouse methodology

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

INOUE Yukiko
Elucidation of molecular machinery for mouse forebrain compartmentalization

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

INOUE Takayoshi, INOUE Yukiko

Profile Information

Research Areas

Research History

Awards

Major Papers

Major Misc.

Presentations

Professional Memberships

Research Projects

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