Yuka W Iwasaki

Profile Information

Affiliation: Team Director, Center for Integrative Medical Sciences, RIKEN

Degree: Ph.D.(Keio University)

Contact information: yiwasakiriken.jp
Researcher number: 80612647
J-GLOBAL ID: 201801012284992217
researchmap Member ID: B000298033

External link: https://www.yokohama.riken.jp/iwasakilab/eindex.html

Research Interests

Research Areas

Research History

Apr, 2025 - Present

Team Director, Center for Integrative Medical Sciences, RIKEN
Jan, 2023 - Mar, 2025

Team Leader, Center for Integrated Medical Sciences, RIKEN
Dec, 2020 - Mar, 2024

PRESTO Researcher, Japan Science and Technology Agency
May, 2020 - Dec, 2022

Associate Professor, Keio University School of Medicine
Aug, 2016 - Apr, 2020

Assistant Professor, Keio University School of Medicine
Aug, 2012 - Jul, 2016

Instructor, Keio University School of Medicine
Apr, 2011 - Jul, 2012

Postdoc, Keio University School of Medicine
Apr, 2008 - Mar, 2011

Research Fellowship for Young Scientists, Japan Society for the Promotion of Science
Jan, 2009 - Dec, 2010

Visiting PhD Student, Max Planck Institute of Immunobiology and Epigenetics

Education

Apr, 2006 - Mar, 2011

Graduate School of Media and Governance, Keio University
Apr, 2002 - Mar, 2006

Faculty of Environment and Information Studies, Keio University

Papers

Transposon–host arms race: a saga of genome evolution

Yuka W. Iwasaki, Keisuke Shoji, Shinichi Nakagwa, Tomoichiro Miyoshi, Yukihide Tomari

Trends in Genetics, Feb, 2025 Peer-reviewed
Drosophila Piwi distinguishes transposons from mRNAs by piRNA complementarity and abundance

Masaru Ariura, Therese Solberg, Hirotsugu Ishizu, Hazuki Takahashi, Piero Carninci, Haruhiko Siomi, Yuka W. Iwasaki

Cell Reports, 43(12) 115020, Dec 24, 2024 Peer-reviewed
Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction

Yu Yamada, Taketaro Sadahiro, Koji Nakano, Seiichiro Honda, Yuto Abe, Tatsuya Akiyama, Ryo Fujita, Masashi Nakamura, Takashi Maeda, Yuta Kuze …

Circulation, Dec 14, 2024 Peer-reviewed
PIGB maintains nuclear lamina organization in skeletal muscle of Drosophila

Miki Yamamoto-Hino, Masaru Ariura, Masahito Tanaka, Yuka W Iwasaki, Kohei Kawaguchi, Yuta Shimamoto, Satoshi Goto

The Journal of cell biology, 223(2), Feb 5, 2024 Peer-reviewed
In preprints: revisiting RNA in PRC2

Yuka W. Iwasaki, Haruhiko Koseki, Shinsuke Ito

Development, 150(22), Nov 15, 2023 Peer-reviewed
Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers

Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W Iwasaki

Nucleic Acids Research, 50(20) 11580-11599, Nov 11, 2022 Peer-reviewed
Generation of Stable Drosophila Ovarian Somatic Cell Lines Using the piggyBac System

Chikara Takeuchi, Kensaku Murano, Mitsuru Ishikawa, Hideyuki Okano, Yuka W. Iwasaki

Methods in Molecular Biology, 2509 143-153, Jul, 2022 Peer-reviewed
Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis

Hiromi Yamada, Kazumichi M. Nishida, Yuka W. Iwasaki, Yosuke Isota, Lumi Negishi, Mikiko C. Siomi

Nature Communications, 13(1) 1518-1518, Mar, 2022 Peer-reviewed
Maelstrom functions in the production of Siwi-piRISC capable of regulating transposons in Bombyx germ cells

Yurika Namba, Yuka W. Iwasaki, Kazumichi M. Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C. Siomi

iScience, 25(3) 103914-103914, Feb, 2022 Peer-reviewed
Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19

Kodai Abe, Yasuaki Kabe, Susumu Uchiyama, Yuka W. Iwasaki, Hirotsugu Ishizu, Yoshifumi Uwamino, Toshiki Takenouchi, Shunsuke Uno, Makoto Ishii, Takahiro Maruno …

Scientific Reports, 12(1) 1299-1299, Jan 25, 2022 Peer-reviewed
Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters

Hidetoshi Hasuwa, Yuka W. Iwasaki, Wan Kin Au Yeung, Kyoko Ishino, Harumi Masuda, Hiroyuki Sasaki, Haruhiko Siomi

Nature Cell Biology, Sep 6, 2021 Peer-reviewed
Piwi–piRNA complexes induce stepwise changes in nuclear architecture at target loci

Yuka W Iwasaki, Sira Sriswasdi, Yasuha Kinugasa, Jun Adachi, Yasunori Horikoshi, Aoi Shibuya, Wataru Iwasaki, Satoshi Tashiro, Takeshi Tomonaga, Haruhiko Siomi

The EMBO Journal, 40(18) e108345, Aug 2, 2021 Peer-reviewed
Rewiring of chromatin state and gene expression by transposable elements

Hitoshi Ohtani, Yuka W. Iwasaki

Development, Growth & Differentiation, May 29, 2021 Peer-reviewed
Identification of B.1.346 Lineage of SARS-CoV-2 in Japan: Genomic Evidence of Re-entry of Clade 20C

Kodai Abe, Takako Shimura, Toshiki Takenouchi, Yuka W. Iwasaki, Hirotsugu Ishizu, Yoshifumi Uwamino, Shunsuke Uno, Jun Gotoh, Natsuo Tachikawa, Yuriko Takeuchi …

The Keio Journal of Medicine, 70(2) 44-50, Apr, 2021 Peer-reviewed
Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation

Kyoko Ishino, Hidetoshi Hasuwa, Jun Yoshimura, Yuka W Iwasaki, Hidenori Nishihara, Naomi M Seki, Takamasa Hirano, Marie Tsuchiya, Hinako Ishizaki, Harumi Masuda …

Nucleic Acids Research, 49(5) 2700-2720, Mar, 2021 Peer-reviewed
Clinical Utility of SARS-CoV-2 Whole Genome Sequencing in Deciphering Source of Infection

Toshiki Takenouchi, Yuka W. Iwasaki, Sei Harada, Hirotsugu Ishizu, Yoshifumi Uwamino, Shunsuke Uno, Asami Osada, Kodai Abe, Naoki Hasegawa, Mitsuru Murata …

Journal of Hospital Infection, 107 40-44, Oct, 2020 Peer-reviewed
Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing

Kensaku Murano, Yuka W Iwasaki, Hirotsugu Ishizu, Akane Mashiko, Aoi Shibuya, Shu Kondo, Shungo Adachi, Saori Suzuki, Kuniaki Saito, Tohru Natsume …

The EMBO journal, 38(17) e102870, Sep 2, 2019 Peer-reviewed
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.

Sadahiro T, Isomi M, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tamura F, Tani H, Tohyama S, Fujita J …

Cell stem cell, 23(3) 382-395, Sep, 2018 Peer-reviewed
Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis.

Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC

Nature, 555(7695) 260-264, Mar, 2018 Peer-reviewed
Profiling Open Chromatin Structure in the Ovarian Somatic Cells Using ATAC-seq.

Murano K, Iwasaki YW, Siomi H

Methods in molecular biology (Clifton, N.J.), 1680 165-177, 2018 Peer-reviewed

Misc.

Transcriptional Repression by Non-Coding RNA

Yuka W. Iwasaki

SEIKAGAKU, 96(6) 813-823, Dec, 2024
piRNA-mediated genomic defense against transposable elements

Ryo Onishi, Yuka W. Iwasaki

実験医学増刊 “情報”から“マテリアル”へノンコーディングRNA研究, 42(15), Sep, 2024
piRNA -配列解析にむけた精製-

山田紘実, 岩崎由香

実験医学別冊誰でも再現できるNGS「前」サンプル調製プロトコール, Jul, 2024
piRNAと生殖

岩崎由香

RNAの科学 -時代を拓く生体分子-, Jun, 2024
Functions of the Non-Coding Genomic Regions

Yuka W. Iwasaki

KEIO SFC JOURNAL, 22(2) 94-106, Mar, 2023
内在性小分子RNAの網羅的解析手法

岩崎由香

実験医学別冊エピジェネティクス実験スタンダード, 311-322, May, 2017
PiwiはヒストンH1を介したクロマチンの構造の制御により標的となるトランスポゾンを抑制する

岩崎由香, 塩見春彦, 齋藤都暁

ライフサイエンス新着論文レビュー FIRST AUTHOR'S, Aug, 2016
small RNAのマイルストーン研究 piRNA(PIWI‐interacting RNA)16.piRNAクラスタ

岩崎由香

実験医学, 33(20) 3252-3253, Dec 10, 2015
ncRNA研究をはじめよう 2.ncRNAのバイオインフォマティクス解析

岩崎由香, 岩崎渉

実験医学, 33(20) 3379-3384, Dec, 2015
KrimpはAGO3とセンスpiRNAとの相互作用を制御することによりアンチセンスpiRNAの産生を促進する

佐藤薫, 岩崎由香, 塩見美喜子, 塩見春彦

ライフサイエンス新着論文レビュー FIRST AUTHOR'S, Aug, 2015
転移因子・ウイルスと宿主の“せめぎ合い”と遺伝子サイレンシング 2.小分子RNAを介したゲノムレベルの自己と非自己の認識

岩崎由香, 齋藤都暁

実験医学, 31(7) 1062-1070, May 1, 2013

Presentations

Transcriptional silencing of transposons by SPIN1 in multiple contexts

Yuka W. Iwasaki

Cold Spring Harbor Asia "The Repetitive and Mobile Genome", CSH-Asia (Suzhou, China), Apr, 2025
Understanding and Regulating the Functions of Non-coding RNAs

Yuka W. Iwasaki

19th RIKEN DMP Seminar Series "non-coding RNA and Pharmaceuticals", Virtual seminar, Feb, 2025
Transcriptional silencing by small non-coding RNAs

Yuka W. Iwasaki

Japan-UK Synthetic Biology Conference, Osaka International Convention Center (Osaka), Feb, 2025
Transposons and their Regulatory Mechanisms Shape Chromatin States and Gene Expression

Yuka W. Iwasaki

Advanced Research Seminar 2024, Keio Univ Institute for Advanced Biosciences (Tsuruoka), Jan, 2025
Nuclear regulation of transposons by small non-coding RNAs

Yuka W. Iwasaki

International Symposium: The 3D Genome, RIKEN Kobe (Kobe), Nov, 2024
Small RNA-mediated regulation of transposons in germline development

Yuka W. Iwasaki

The 47th Annual Meeting of the Molecular Biology Society of Japan, Fukuoka International Congress Center (Fukuoka), Nov, 2024
piRNA Targeting Rules Distinguish Transposons from mRNAs

Yuka W. Iwasaki

36th Tokyo RNA Club, RIKEN Yokohama (Yokohama), Nov, 2024
Regulation of transposons during germline development

Yuka W. Iwasaki

The Genetics Society of Japan 96th Annual Meeting, Kochi University of Technology (Kochi), Sep, 2024
PIWI-piRNA-mediated silencing of transposable elements

Yuka W. Iwasaki

International Symposium on Epigenetics 2024, Genopolys (Montpellier, France), Jul, 2024
Epigenetic regulation of transposons by small non-coding RNAs

Yuka W. Iwasaki

International Summer-School on Epigenetics 2024, Genopolys (Montpellier, France), Jul, 2024
Small RNA-mediated genome defense from transposable elements

Yuka W. Iwasaki

RIKEN IMS-JSI International Symposium on Immunology 2024 “Cultivating Immunity for Health”, Ito Hall (Tokyo), Jun, 2024
Impact of small RNA-mediated transposon repression on fertility phenotype

Yuka W. Iwasaki

Tokyo Symposium & Workshop on Genomic Medicine, Therapeutics and Health, Hitotsubashi Hall (Tokyo), Apr, 2024
ゲノム構造変化を介したトランスポゾンの転写抑制機構

岩崎由香

第６回ゲノム生物物理学セミナー、オンライン, Mar, 2024
Small RNA-mediated regulatory mechanism of transposable elements

Yuka W. Iwasaki

OIST-JST Joint Meeting, OIST (Okinawa), Jan, 2024
Genomic plasticity shaped by the antagonism between transposons and their regulatory mechanisms

Yuka W. Iwasaki

The 97th Annual Meeting of the Japanese Pharmacological Society, Port Island (Kobe, Japan), Dec, 2023
Transcriptional regulation of telomeric transposon via enhancer architecture

Yuka W. Iwasaki

第46回日本分子生物学会年会，神戸ポートアイランド（神戸）, Dec, 2023
Decoding the Non-coding Genome

Yuka W. Iwasaki

The 1st OIST-RIKEN Meeting, OIST (Okinawa), Nov, 2023
Co-transcriptional silencing by nuclear PIWI-piRNA complex

Yuka W. Iwasaki

The 3rd Asia RNA Club, Virtual conference, Sep, 2023
小分子 RNA によるヘテロクロマチン形成を介した転写制御

岩崎由香

第3回有性生殖研究会「生殖の多様性」，理化学研究所（神戸）, Mar, 2023
Co-transcriptional silencing and heterochromatin formation by nuclear PIWI-piRNA complex

Yuka W. Iwasaki

Cold Spring Harbor Asia "RNA biology meeting", Awaji Yumebutai Conference Center (Awaji, Japan), Dec, 2022

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Presentations

Menu

Coauthors