Yayoi Izu

Profile Information

Affiliation: 准教授, 獣医学部, 岡山理科大学

J-GLOBAL ID: 202001015850591109
researchmap Member ID: R000006432

Research Interests

Extracellular Matrix, Collagens, tendons and Ligaments. Bone

Research Areas

Research History

2018 - Present

Associate Professor, Department of Veterinary Medicine, Okayama University of Science
2016 - 2018

Lecturer, Faculty of Risk and Crisis Management, Department of Risk and Crisis Management for Animals, Chiba Institute of Science
2014 - 2016

Assistant professor, Medical Research Institute, Tokyo Medical and Dental University
2013 - 2014

Research Associate, College of Medicine, University of South Florida
2010 - 2013

postdoctoral fellow, college of Medicine, Pennstate University
2008 - 2010

Postdoctoral fellow, College of Medicine, University of South Floria
Apr, 2006 - Jul, 2008

Medical Research Institute, Tokyo medical and dental university

Education

Apr, 2002 - Mar, 2006

獣医学専攻, 獣医学研究科博士課程, 日本獣医畜産大学（現日本獣医生命科学大学）
Apr, 1996 - Apr, 2002

獣医学科, 獣医学部, 日本獣医畜産大学（現日本獣医生命科学大学）

Awards

Major Papers

Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function

Yayoi Izu, Sheila M. Adams, Brianne K. Connizzo, David P. Beason, Louis J. Soslowsky, Manuel Koch, David E. Birk

Matrix Biology, Oct, 2020 Peer-reviewedLead authorCorresponding author
Collagens VI and XII form complexes mediating osteoblast interactions during osteogenesis.

Yayoi Izu, Yoichi Ezura, Manuel Koch, David E Birk, Masaki Noda

Cell and tissue research, 364(3) 623-635, Jun, 2016 Peer-reviewedLead authorCorresponding author
Erratum to: Collagens VI and XII form complexes mediating osteoblast interactions during osteogenesis.

Yayoi Izu, Yoichi Ezura, Manuel Koch, David E Birk, Masaki Noda

Cell and tissue research, 364(3) 677-679, Jun, 2016 Peer-reviewed
Type VI collagen deficiency induces osteopenia with distortion of osteoblastic cell morphology.

Yayoi Izu, Yoichi Ezura, Fumitaka Mizoguchi, Aya Kawamata, Tetsuya Nakamoto, Kazuhisa Nakashima, Tadayoshi Hayata, Hiroaki Hemmi, Paolo Bonaldo, Masaki Noda

Tissue & cell, 44(1) 1-6, Feb, 2012 Peer-reviewed
Type XII collagen regulates osteoblast polarity and communication during bone formation.

Yayoi Izu, Mei Sun, Daniela Zwolanek, Guido Veit, Valerie Williams, Byeong Cha, Karl J Jepsen, Manuel Koch, David E Birk

The Journal of cell biology, 193(6) 1115-30, Jun 13, 2011 Peer-reviewed
Dysfunctional tendon collagen fibrillogenesis in collagen VI null mice.

Yayoi Izu, Heather L Ansorge, Guiyun Zhang, Louis J Soslowsky, Paolo Bonaldo, Mon-Li Chu, David E Birk

Matrix biology : journal of the International Society for Matrix Biology, 30(1) 53-61, Jan, 2011 Peer-reviewed
Angiotensin II type 2 receptor blockade increases bone mass.

Yayoi Izu, Fumitaka Mizoguchi, Aya Kawamata, Tadayoshi Hayata, Testuya Nakamoto, Kazuhisa Nakashima, Tadashi Inagami, Yoichi Ezura, Masaki Noda

The Journal of biological chemistry, 284(8) 4857-64, Feb 20, 2009 Peer-reviewed
Distribution of type VI collagen in the cartilaginous tissue of the proximal tibia in the domestic cat.

Yayoi Izu, Satoshi Soeta, Shinji Kamiya, Toru R Saito, Shuji Yamano, Kazuyuki Taniguchi

The Journal of veterinary medical science, 67(9) 927-33, Sep, 2005 Peer-reviewed

Misc.

Aging Dependent and Independent Effects of b2 Adrenergic Receptor Signaling on Bone Formation Induced by Intermittent PTH Treatment Female Mice

R. Hanyu, Y. Saita, J. Nagata, Y. Izu, H. Hemmi, S. Takade, Y. Ezura, H. Kurosawa, M. Noda

JOURNAL OF BONE AND MINERAL RESEARCH, 23 S204-S204, Sep, 2008
Deficiency of the Nucleocytoplasmic Shuttling Protein CIZ Suppresses K/BxN Serum-Induced Model of Rheumatoid Arthritis.

T. Nakamoto, F. Mizoguchi, Y. Izu, T. Hayata, Y. Ezura, D. Mathis, C. Benoist, N. Miyasaka, M. Noda

JOURNAL OF BONE AND MINERAL RESEARCH, 23 S487-S487, Sep, 2008
Role of OPN in Beta-adrenergic Signaling Induced Bone Loss in vivo.

M. Nagao, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, Y. Ezura, H. Kurosawa, M. Noda

JOURNAL OF BONE AND MINERAL RESEARCH, 23 S416-S416, Sep, 2008
Deficiency of NCK1, an Actin Cytoskeletal Modulator with SH2/SH3 Motifs, Induces Bone Loss via Suppression of Bone Formation and Induction of Biochemical High Bone Turnover State.

K. Miyai, Y. Izu, H. Hemmi, T. Hayata, T. Nakamoto, Y. Ezura, T. Pawson, S. Mizutani, M. Noda

JOURNAL OF BONE AND MINERAL RESEARCH, 23 S380-S380, Sep, 2008
beta 2 adrenergic receptor deficiency enhances bone mass in by antagonizing against aging-induced bone loss and blunts anabolic effects of PTH on osteoblasts

R. Hanyu, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, S. Takeda, Y. Ezura, K. Nakashima, H. Kurosawa …

JOURNAL OF BONE AND MINERAL RESEARCH, 22 S88-S88, Sep, 2007
beta 2 adrenergic receptor deficiency enhances bone mass in by antagonizing against aging-induced bone loss and blunts anabolic effects of PTH on osteoblasts

R. Hanyu, Y. Saita, J. Nagata, Y. Izu, T. Havata, H. Hemmi, S. Takeda, Y. Ezura, K. Nakashima, H. Kurosawa …

JOURNAL OF BONE AND MINERAL RESEARCH, 22 S124-S124, Sep, 2007
beta-adrenergic signaling requires bone matrix protein OPN to suppress bone formation and to activate bone resorption

M. Nagao, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, Y. Ezura, K. Nakashima, H. Kurosawa, M. Noda

JOURNAL OF BONE AND MINERAL RESEARCH, 22 S5-S5, Sep, 2007
Phenotypical heterogeneity between osteoclasts involved in the endochondral ossification and bone remodeling

S. Soeta, Y. Izu, S. Kamiya, H. Amasaki

JOURNAL OF BONE AND MINERAL RESEARCH, 22 S252-S252, Sep, 2007

Research Projects

Elucidation of early bone tissue architecture by in vivo volumetric image analysis-from both sides of cells and bone matrix

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Elucidation of regulatory mechanisms of tendon homeostasis via tenocyte network.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2027
FACITタイプ12型コラーゲンによる運動器制御機構の解明

フロンティア研究者助成, 日本骨代謝学会, 2021 - 2023

伊豆弥生
The role of Collagen 6 in knee anterior cruciate ligament

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Elucidation of collagen XII regulatory role in osteoarthritis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Izu Yayoi
小児希少疾患であるミオパチー型エーラス・ダンロス症候群のエネルギー代謝機構をターゲットとした治療法の開発

森永賞, 森永奉仕会, 2021

伊豆弥生
Molecular Mechanism of Comprehensive Signal for Bone Formation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

NODA Masaki
Elucidation of novel bone matrix regulatory system by collagens VI and XII.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Izu Yayoi, AIDA Tomomi, BIRK David E., KOCH Manuel
Regulation of muscle-tendon-bone networks in locomotive syndrome.

Research foundation, Naito Foundation, 2017
Identification of sarcopenia marker

research award, 2017
interactive regulation of collagens VI and XII causing Ullrich congenital muscular dystrophy in musculoskeletal system,

research award, Nakatomi Foundation, 2017
細胞外基質蛋白質による骨芽細胞動態制御の分子メカニズムの解明

科学研究費助成事業研究活動スタート支援, 研究活動スタート支援, 日本学術振興会, Aug, 2014 - Mar, 2015

伊豆弥生
Elucidation of cell competition mechanism in terminal differentiation of osteoblasts

President's Discretion Young Researcher Encouragement Award, 2015
Elucidation of mechanosensing mechanisms in musculoskeletal system.

Basic research award, Ichiro Kanehara Foundation, 2015
non-fibrillar collagens regulation in bone quality that defines osteoporosis

Medical research grant, Takeda Science Foundation, 2015

Yayoi Izu

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Misc.

Research Projects

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