2012年3月
Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study.
BLOOD
- 巻
- 119
- 号
- 9
- 開始ページ
- 2141
- 終了ページ
- 2148
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1182/blood-2011-07-368233
- 出版者・発行元
- AMER SOC HEMATOLOGY
Allogeneic hematopoietic cell transplantation (HCT) is an effective treatment for adult T-cell leukemia (ATL), raising the question about the role of graft-versus-leukemia effect against ATL. In this study, we retrospectively analyzed the effects of acute and chronic graft-versus-host disease (GVHD) on overall survival, disease-associated mortality, and treatment-related mortality among 294 ATL patients who received allogeneic HCT and survived at least 30 days posttransplant with sustained engraftment. Multivariate analyses treating the occurrence of GVHD as a time-varying covariate demonstrated that the development of grade 1-2 acute GVHD was significantly associated with higher overall survival (hazard ratio [HR] for death, 0.65; P = .018) compared with the absence of acute GVHD. Occurrence of either grade 1-2 or grade 3-4 acute GVHD was associated with lower disease-associated mortality compared with the absence of acute GVHD, whereas grade 3-4 acute GVHD was associated with a higher risk for treatment-related mortality (HR, 3.50; P < .001). The development of extensive chronic GVHD was associated with higher treatment-related mortality (HR, 2.75; P = .006) compared with the absence of chronic GVHD. Collectively, these results indicate that the development of mild-to-moderate acute GVHD confers a lower risk of disease progression and a beneficial influence on survival of allografted patients with ATL. (Blood. 2012; 119(9): 2141-2148)
- リンク情報
-
- DOI
- https://doi.org/10.1182/blood-2011-07-368233
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201202257505293655
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22234682
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000300949500027&DestApp=WOS_CPL
- URL
- http://europepmc.org/abstract/med/22234682
- ID情報
-
- DOI : 10.1182/blood-2011-07-368233
- ISSN : 0006-4971
- J-Global ID : 201202257505293655
- ORCIDのPut Code : 24261761
- PubMed ID : 22234682
- Web of Science ID : WOS:000300949500027