論文

査読有り
2009年4月

Impact of ABO mismatching on the outcomes of allogeneic related and unrelated blood and marrow stem cell transplantations for hematologic malignancies: IPD-based meta-analysis of cohort studies.

TRANSFUSION
  • Kanda J
  • ,
  • Ichinohe T
  • ,
  • Matsuo K
  • ,
  • Benjamin RJ
  • ,
  • Klumpp TR
  • ,
  • Rozman P
  • ,
  • Blumberg N
  • ,
  • Mehta J
  • ,
  • Sohn SK
  • ,
  • Uchiyama T

49
4
開始ページ
624
終了ページ
635
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1537-2995.2008.02043.x
出版者・発行元
WILEY-BLACKWELL PUBLISHING, INC

The impact of donor-recipient ABO matching on outcomes after allogeneic stem cell transplantation has been a matter of controversy.
Individual patient data-based meta-analysis was conducted with a pooled data set provided through six published and one unpublished cohorts. Outcomes in recipients of peripheral blood or bone marrow transplantation for hematologic malignancies were evaluated. A multivariate Cox model was used to adjust differences in outcomes of patients receiving ABO-matched grafts with those receiving major, minor, or bidirectional mismatched grafts. Considering multiple testing, p values of less than 0.05 and 0.001 were considered significant for the primary and secondary endpoints, respectively.
In all, 1208 cases, including 697 ABO-matched and 202 major, 228 minor, and 81 bidirectional mismatched transplants, were analyzed. Overall, adverse impact of ABO matching on overall survival (OS), as a primary endpoint, was not observed (adjusted hazard ratios [95% confidence intervals]: major, 1.03 [0.82-1.30], p = 0.81; minor, 1.19 [0.97-1.47], p = 0.10; bidirectional, 1.25 [0.91-1.72], p = 0.17). Among related stem cell recipients, ABO matching had no significant influence on OS, while the minor and bidirectional mismatched groups among unrelated stem cell recipients exhibited lower OS with marginal significance, especially in patients with acute leukemia, patients who received transplants after 1998, and patients who underwent transplants at Asian centers.
Our meta-analysis demonstrates no adverse association between any ABO mismatching and survival. However, marginally lower OS found in recipients of minor or bidirectional mismatched grafts from unrelated donors suggested the need for larger studies focusing on unrelated transplants.

リンク情報
DOI
https://doi.org/10.1111/j.1537-2995.2008.02043.x
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201302210179287616
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19170998
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000264380000007&DestApp=WOS_CPL
URL
http://europepmc.org/abstract/med/19170998
ID情報
  • DOI : 10.1111/j.1537-2995.2008.02043.x
  • ISSN : 0041-1132
  • J-Global ID : 201302210179287616
  • ORCIDのPut Code : 24261782
  • PubMed ID : 19170998
  • Web of Science ID : WOS:000264380000007

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