Yoshinori Kato

J-GLOBAL         Last updated: Sep 30, 2019 at 19:59
Yoshinori Kato
Hoshi University
Job title
Associate Professor
Ph.D.(Hoshi University)
Other affiliation
The Johns Hopkins University School of Medicine

Research Areas


Academic & Professional Experience

Jan 2018
Associate Professor, Laboratory of Biofunctional Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences
Aug 2014
Adjunct Assistant Professor, Department of Radiology, The Johns Hopkins University School of Medicine
Sep 2014
Dec 2017
Associate Professor, Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences
Dec 2008
Jul 2014
Affiliated faculty, Institute for NanoBioTechnology, The Johns Hopkins University
Dec 2008
Jul 2014
Assistant Professor, Dept. of Oncology, The Johns Hopkins University School of Medicine


Apr 1999
Mar 2002
Ph.D., Dept. of Drug Delivery Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences
Apr 1997
Mar 1999
M.S., Department of Drug Delivery Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences
Apr 1993
Mar 1997
B.S., Hoshi University School of Pharmacy and Pharmaceutical Sciences

Committee Memberships

May 2015
Apr 2018
APSTJ  Editorial member of YAKUZAIGAKU

Published Papers

Bar-Shir A., Alon L., Korrer M.J., Lim H.S., Yadav N.N., Kato Y., Pathak A.P., Bulte J.W.M., Gilad A.A.
Magnetic Resonance in Medicine   79(2) 1010-1019   Feb 2018   [Refereed]
Sagara A, Igarashi K, Otsuka M, Kodama A, Yamashita M, Sugiura R, Karasawa T, Arakawa K, Narita M, Kuzumaki N, Narita M, Kato Y
Breast cancer research and treatment   161 269-278   Jan 2017   [Refereed]
Sagara A, Igarashi K, Otsuka M, Karasawa T, Gotoh N, Narita M, Kuzumaki N, Narita M, Kato Y
PloS one   11(10) e0164250   Oct 2016   [Refereed]
Xie M, Vesuna F, Botlagunta M, Bol G.M, Irving A, Bergman Y, Hosmane R.S, Kato Y, Winnard P.T, Raman V.
Oncotarget   6(30) 29901-29913   Oct 2015   [Refereed]
Bol G.M, Khan R, Heerma Van Voss M.R, Tantravedi S, Korz D, Kato Y, Raman V.
Cancer Chemotherapy and Pharmacology   76(4) 821-827   Oct 2015   [Refereed]
Hapuarachchige S, Kato Y, Ngen EJ, Smith B, Delannoy M, Artemov D
PloS one   11(5) e0156294   May 2016   [Refereed]
Chettiar ST, Malek R, Annadanam A, Nugent KM, Kato Y, Wang H, Cades JA, Taparra K, Belcaid Z, Ballew M, Manmiller S, Proia D, Lim M, Anders RA, Herman JM, Tran PT
Cancer biology & therapy   17(4) 457-466   Apr 2016   [Refereed]
Hapuarachchige S, Kato Y, Artemov D
Scientific reports   6 24298   Apr 2016   [Refereed]
Xu X, Chan KW, Knutsson L, Artemov D, Xu J, Liu G, Kato Y, Lal B, Laterra J, McMahon MT, van Zijl PC
Magnetic resonance in medicine   74(6) 1556-1563   Dec 2015   [Refereed]
Ngen E.J, Wang L, Kato Y, Krishnamachary B, Zhu W, Gandhi N, Smith B, Armour M, Wong J, Gabrielson K, Artemov D.
Scientific Reports   5    2015   [Refereed]
Kato Y, Zhu W, Backer M.V, Neoh C.C, Hapuarachchige S, Sarkar S.K, Backer J.M, Artemov D.
Pharmaceutical Research   32(11) 3746-3755   2015   [Refereed]
Tristan C.A, Ramos A, Shahani N, Emiliani F.E, Nakajima H, Noeh C.C, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak T.W, Ishizuka K, Ichijo H, Sawa A.
Journal of Biological Chemistry   290(1) 56-64   2015   [Refereed]
Hapuarachchige S, Zhu W, Kato Y, Artemov D.
Biomaterials   35(7) 2346-2354   2014   [Refereed]
Zhu W, Kato Y, Artemov D.
Magnetic Resonance Materials in Physics, Biology and Medicine   27(2) 161-170   2014   [Refereed]
Gandhi N, Wild A.T, Chettiar S.T, Aziz K, Kato Y, Gajula R.P, Williams R.D, Cades J.A, Annadanam A, Song D, Zhang Y, Hales R.K, Herman J.M, Armour E, DeWeese T.L, Schaeffer E.M, Tran P.T.
Cancer Biology and Therapy   14(4) 347-356   2013   [Refereed]
Gajula R.P, Chettiar S.T, Williams R.D, Thiyagarajan S, Kato Y, Aziz K, Wang R, Gandhi N, Wild A.T, Vesuna F, Ma J, Salih T, Cades J, Fertig E, Biswal S, Burns T.F, Chung C.H, Rudin C.M, Herman J.M, Hales R.K, Raman V, An S.S, Tran P.T.
Molecular Cancer Research   11(11) 1387-1400   2013   [Refereed]
Chan K.W.Y, McMahon M.T, Kato Y, Liu G, Bulte J.W.M, Bhujwalla Z.M, Artemov D, Van Zijl P.C.M.
Magnetic Resonance in Medicine   68(6) 1764-1773   2012   [Refereed]
Vesuna F, Lisok A, Kimble B, Domek J, Kato Y, Van Der Groep P, Artemov D, Kowalski J, Carraway H, Van Diest P, Raman V.
Oncogene   31(27) 3223-3234   2012   [Refereed]
Qiao Y, Huang X, Nimmagadda S, Bai R, Staedtke V, Foss C.A, Cheong I, Holdhoff M, Kato Y, Pomper M.G, Riggins G.J, Kinzler K.W, Diaz Jr. L.A.J, Vogelstein B, Zhou S.
Oncotarget   2(1-2) 59-68   2011   [Refereed]
Kato Y, Holm D.A, Okollie B, Artemov D.
Neuro-Oncology   12(1) 71-79   2010   [Refereed]
Onuki Y, Jacobs I, Artemov D, Kato Y.
Biomaterials   31(27) 7132-7138   2010   [Refereed]
Mikhaylova M, Stasinopoulos I, Kato Y, Artemov D, Bhujwalla Z.M.
Cancer Gene Therapy   16(3) 217-226   2009   [Refereed]
Kato Y, Artemov D.
Magnetic Resonance in Medicine   61(5) 1059-1065   2009   [Refereed]
Kato Y, Okollie B, Raman V, Vesuna F, Zhao M, Baker S.D, Bhujwalla Z.M, Artemov D.
Cancer Biology and Therapy   6(6) 891-897   2007   [Refereed]
Winnard Jr. P.T, Kluth J.B, Kato Y, Artemov D, Raman V.
Cancer Biology and Therapy   6(12) 1889-1899   2007   [Refereed]
Har-El Y.-E, Kato Y.
Current Nanoscience   3(4) 329-338   2007   [Refereed]
Kato Y, Okollie B, Artemov D.
Magnetic Resonance in Medicine   55(4) 755-761   2006   [Refereed]
Kato Y, Onishi H, Machida Y.
In Vivo   19(1) 301-310   2005   [Refereed]
Mironchik Y, Winnard Jr. P.T, Vesuna F, Kato Y, Wildes F, Pathak A.P, Kominsky S, Artemov D, Bhujwalla Z, Van Diest P, Burger H, Glackin C, Raman V.
Cancer Research   65(23) 10801-10809   2005   [Refereed]
Inoue K, Onishi H, Kato Y, Michiura T, Nakai K, Sato M, Yamamichi K, Machida Y, Nakane Y.
Cancer Chemotherapy and Pharmacology   53(5) 415-422   2004   [Refereed]
Kato Y, Onishi H, Machida Y.
Biomaterials   25(5) 907-915   2004   [Refereed]
Takehana J, Kato Y, Onishi H, Nagai T, Machida Y.
S.T.P. Pharma Sciences   13(4) 253-258   2003   [Refereed]
Kato Y, Onishi H, Machida Y.
Current Pharmaceutical Biotechnology   4(5) 303-309   2003   [Refereed]
Katayama K, Kato Y, Onishi H, Nagai T, Machida Y.
Drug Development and Industrial Pharmacy   29(7) 725-731   2003   [Refereed]
Yamabe K, Kato Y, Onishi H, Machida Y.
Journal of Controlled Release   90(1) 71-79   2003   [Refereed]
Ebato Y, Kato Y, Onishi H, Nagai T, Machida Y.
Drug Development Research   58(3) 253-257   2003   [Refereed]
Yamabe K, Kato Y, Onishi H, Machida Y.
Journal of Controlled Release   89(3) 429-436   2003   [Refereed]
Takahashi Y, Kato Y, Onishi H, Machida Y, Iwata M, Yamada R, Nakajima H.
Skin Research   2(2) 87-93   2003   [Refereed]
Kato Y, Onishi H, Machida Y.
Carbohydrate Research   337(6) 561-564   2002   [Refereed]
Kato Y, Onishi H, Machida Y.
Journal of Pharmacy and Pharmacology   54(4) 529-537   2002   [Refereed]
Ishikawa O, Kato Y, Onishi H, Nagai T, Machida Y.
International Journal of Pharmaceutics   249(1-2) 81-88   2002   [Refereed]
Katayama K, Kato Y, Onishi H, Nagai T, Machida Y.
International Journal of Pharmaceutics   248(1-2) 93-99   2002   [Refereed]
Kato Y, Onishi H, Machida Y.
Anticancer Research   22(5) 2771-2776   2002   [Refereed]
Kato Y, Onishi H, Machida Y.
Journal of Controlled Release   70(3) 295-307   2001   [Refereed]
Kato Y, Onishi H, Machida Y.
International Journal of Pharmaceutics   226(1-2) 93-106   2001   [Refereed]
Kato Y, Onishi H, MacHida Y.
Biomaterials   21(15) 1579-1585   2000   [Refereed]


Kato Y, Pathak A.P.
Nanoimaging   1-17   2011   [Invited]
Kato Y.
Current Pharmaceutical Biotechnology   4(5)    2003   [Invited]

Books etc

Yoshinori Kato, Arvind P. Pathak (Part:Contributor, 1-17)
Pan Stanford Publishing Pte Ltd.   2011   

Conference Activities & Talks

Bioorthogonal, two-component delivery systems based on antibody and drug-loaded nanocarriers for enhanced internalization of nanotherapeutics
Feb 2014   

Research Grants & Projects

National Institutes of Health: P50
Project Year: Sep 2011 - Jul 2016    Investigator(s): Zaver M. Bhujwalla
This center grant funds an In vivo Cellular and Molecular Imaging Center at Johns Hopkins. The program consists of four research components, four developmental projects, one career development award and four resources.
Image-guided Combination Therapy: Noninvasive Assessment of Delivery And Response
National Institutes of Health: R01
Project Year: Sep 2011 - Jul 2016    Investigator(s): Dmitri Artemov, Joseph M. Backer; Susanta K. Sarkar
The objectives of this R01 application are to develop a targeted image-guided drug delivery platform to facilitate antiangiogenic therapy in breast cancer and to understand mechanisms of tumor aggressiveness and resistance to therapy under hypoxia.
Evaluation of stemness of human breast cancer cell line and its metastatic variants
Cancer Research Institute, Kanazawa University: Collaborative project
Project Year: Apr 2015 - Mar 2016    Investigator(s): Yoshinori Kato
Molecular imaging of exosomes in the lung metastatic niche
National Institutes of Health: Developmental Project of the JHU ICMIC Program
Project Year: Aug 2013 - Jul 2015    Investigator(s): Yoshinori Kato, Farhad Vesuna
The objective of this project was to elucidate the role of cancer cell-derived exosomes in the development of the lung metastatic niche in breast cancer.
Novel Two-Component Delivery System Based on Her-2/neu Receptor Internalization Strategy
Susan G. Komen for the Cure®: 
Project Year: Apr 2010 - Apr 2014    Investigator(s): Dmitri Artemov
The major goal of this project is to develop predictive multiscale models of breast cancer. Mouse model xenografts of human breast cancer will be used; multiscale imaging studies and molecular studies will provide the foundation for models valida...
Noninvasive Imaging of Stem Cell Homing and Viability
TEDCO Maryland Stem Cell Research Fund: 
Project Year: Sep 2010 - Aug 2013    Investigator(s): Dmitri Artemov
In this proposal, we used a novel MR imaging based method that enables noninvasive monitoring of stem cell migration and viability status using established procedures of stem cell labeling with magnetic markers.
A novel RNA helicase inhibitor to treat breast cancer
Department of Defense, Breast Cancer Research Program: Idea Award
Project Year: Aug 2010 - Aug 2013    Investigator(s): Venu Raman
The major objective of this proposal was to longitudinally image and delineate the therapeutic impact of a novel RNA helicase inhibitor to treat breast cancer.
A Targeted Theranostic Nanoprobe For Real-Time Imaging of HSV1-TK in Brain Tumors
Johns Hopkins Center of Cancer Nanotechnology Excellence: CCNE Pilot Project
Project Year: May 2012 - Apr 2013    Investigator(s): Assaf Gilad, Yoshinori Kato, Arvind P. Pathak
The purpose of this study was to develop a targeted theranostic nanoprobe and provide a tool for real-time monitoring of delivery and release of pro-drugs for HSV1-tk in a pre-clinical brain tumor model.
Activated nano-sized MR contrast agents for imaging of tumor proteolytic activity
National Institutes of Health: R21
Project Year: Sep 2009 - Aug 2012    Investigator(s): Dmitri Artemov
The main purpose of this project is to develop an activated MRI contrast agent sensitive to activities of proteolytic tumor enzymes that can be important biomarkers of tumor aggressiveness and invasiveness.
Noninvasive Monitoring of In Vivo Drug Release
National Institutes of Health: R21
Project Year: Jun 2008 - May 2012    Investigator(s): Yoshinori Kato
The goal of this study was to monitor the in vivo release of drugs/MR contrast agents from liposomes and nano/microspheres and the subsequent intratumoral distribution.
Microimaging of Nanocarrier Delivery in Brain Tumor Therapy
Institute for NanoBioTechnology at JHU: Junior Faculty proposal
Project Year: May 2010 - Apr 2011    Investigator(s): Arvind P. Pathak, Yoshinori Kato, Jiangyang Zhang
This study characterized the neurovasculature in brain tumors, and clarified its effect on the distribution of drug carriers, such as nanoparticulate liposomes.
New Strategy for Cancer Therapy: Development of New Nanocarrier System
The Nagai Foundation Tokyo: Research Grant
Project Year: Apr 2010 - Mar 2011    Investigator(s): Yoshinori Kato
We developed a vinorelbine-loaded, olive oil-based water-in-oil-in-water nanoemulsion, and evaluated its feasibility as a new nanocarrier in a preclinical prostate cancer model.
MR Pharmacoangiography – Vascular Modulation of Delivery
National Institutes of Health: R56
Project Year: Sep 2007 - Aug 2010    Investigator(s): Dmitri Artemov
We have developed a noninvasive MR method for direct detection of 13C-labeled temozolomide in preclinical breast tumor models. This project is focused on (i) noninvasive monitoring of the delivery of 13C-labeled TMZ in human glioma models, and (i...
Targeted Imaging and Therapy of Breast Cancer Stem-like Cells
TEDCO Maryland Stem Cell Research Fund: Exploratory Research Grants
Project Year: Jul 2008 - Jun 2010    Investigator(s): Dmitri Artemov
This project was focused on targeted imaging and therapy of breast cancer stem-like cells.
A lectin-contrast agent for multimodality molecular imaging of tumor angiogenesis
National Institutes of Health: R21
Project Year: Apr 2008 - Mar 2010    Investigator(s): Arvind P. Pathak
The primary goal of this project was to develop a de novo lectin-targeted imaging probe that improves our ability to image the structural and functional changes in tumor blood vessels during angiogenesis, using molecular magnetic resonance imaging...
Visualization of In Vivo Release Characteristics and Intratumoral Distribution of Anticancer Drug-Loaded Nanoparticles
The Nagai Foundation Tokyo: Research Grant
Project Year: Apr 2007 - Mar 2009    Investigator(s): Yoshinori Kato
Molecular MR Imaging of Protease Activity in Breast Cancer with Activated Contrast Agents
Department of Defense, Breast Cancer Research Program: Concept Award
Project Year: Sep 2007 - Sep 2008    Investigator(s): Dmitri Artemov