2017年
Prognosis of oral squamous cell carcinoma patients with level IV/V metastasis: An observational study
Journal of Cranio-Maxillofacial Surgery
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- 巻
- 45
- 号
- 1
- 開始ページ
- 145
- 終了ページ
- 149
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jcms.2016.10.011
- 出版者・発行元
- CHURCHILL LIVINGSTONE
PURPOSE: The objectives of this study were to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma (OSCC) with level IV/V metastases, and to evaluate the multivariate relationships among potential risk factors for metastasis and prognosis. MATERIALS AND METHODS: We evaluated 291 patients (178 men and 113 women; mean age, 65.9 ± 13.5 years). Clinicopathological data, time of development of level IV/V metastases, and clinical course were investigated. RESULTS: Twenty-three patients (7.9%) developed level IV/V metastases. The 3-year overall survival rates when level IV/V metastasis first developed were 27.3% upon initial treatment, 57.1% when metachronous neck metastasis developed, and 40.0% when the tumor recurred. Oral tongue tumor subsite, high N staging, neck dissection when metachronous neck metastasis developed, as well as recurrence were independent risk factors for level IV/V metastasis. CONCLUSION: We demonstrate here the multivariate relationships among the risk factors indicated above for level IV/V metastasis and their prognostic significance for patients with OSCC. Oral tongue tumors, high N staging, and neck dissection upon the occurrence of metachronous neck metastasis or recurrence were risk factors for level IV/V metastasis and positive extracapsular spread, presence of multiple lymph metastases, and moderate or poor differentiation were poor prognostic factors.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.jcms.2016.10.011
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27908710
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000392686800022&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85007324642&partnerID=MN8TOARS
- ID情報
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- DOI : 10.1016/j.jcms.2016.10.011
- ISSN : 1010-5182
- eISSN : 1878-4119
- ORCIDのPut Code : 84353626
- PubMed ID : 27908710
- SCOPUS ID : 85007324642
- Web of Science ID : WOS:000392686800022