2021年
Hair follicle stem cell progeny heal blisters while pausing skin development
EMBO Reports
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.15252/embr.202050882
Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases.
- リンク情報
- ID情報
-
- DOI : 10.15252/embr.202050882
- ISSN : 1469-221X
- eISSN : 1469-3178
- PubMed ID : 34085753
- SCOPUS ID : 85107117524