論文

査読有り 国際誌
2019年

Alterations in serotonin transporter and body image-related cognition in anorexia nervosa.

NeuroImage. Clinical
  • Masamichi Yokokura
  • ,
  • Tatsuhiro Terada
  • ,
  • Tomoyasu Bunai
  • ,
  • Kyoko Nakaizumi
  • ,
  • Yasuhiko Kato
  • ,
  • Etsuji Yoshikawa
  • ,
  • Masami Futatsubashi
  • ,
  • Katsuaki Suzuki
  • ,
  • Hidenori Yamasue
  • ,
  • Yasuomi Ouchi

23
開始ページ
101928
終了ページ
101928
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.nicl.2019.101928

The serotonin system has been implicated in the pathophysiology of anorexia nervosa (AN). A recent report proposed that body image distortion (BID), a core symptom of AN, may relate to abnormalities of the serotonin system, especially the serotonin transporter (5HTT). Positron emission tomography (PET) studies of underweight patients with active AN reported alterations in serotonin receptors, but not 5HTT. Here, we aimed to disclose the clinicopathophysiology of AN by focusing on 5HTT and cognitive functions, including BID, in groups with active AN. Twenty-two underweight female patients with AN (12 restricting-type AN (ANR); 10 binge-eating/purging-type AN (ANBP)) and 20 age-matched healthy female subjects underwent PET with a 5HTT radioligand [11C]DASB. The binding potential (BPND) of [11C]DASB was estimated semiquantitatively, and clinical data from Raven's colored progressive matrices for general intelligence, the Stroop test for focused attention, the Iowa gambling task for decision making and a dot-probe task designed for BID were compared with the levels of BPND in different groups. [11C]DASB BPND was significantly decreased in the medial parietal cortex in patients with AN and in the dorsal raphe in patients with ANR compared with healthy subjects (p < .05 corrected). Patients with ANR showed a significantly negative correlation between [11C]DASB BPND in the dorsal raphe and performance on the dot-probe task (p < .05 corrected). While reduced 5HTT in the medial parietal cortex (the somatosensory association area) is pathophysiologically important in AN in general, additional 5HTT reduction in the dorsal raphe as seen in ANR is implicated for the clinicopathophysiological relevance.

リンク情報
DOI
https://doi.org/10.1016/j.nicl.2019.101928
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31491815
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627582
ID情報
  • DOI : 10.1016/j.nicl.2019.101928
  • PubMed ID : 31491815
  • PubMed Central 記事ID : PMC6627582

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