論文

査読有り
2012年2月

Primitive Duplicate Hox Clusters in the European Eel's Genome

PLOS ONE
  • Christiaan V. Henkel
  • ,
  • Erik Burgerhout
  • ,
  • Danielle L. de Wijze
  • ,
  • Ron P. Dirks
  • ,
  • Yuki Minegishi
  • ,
  • Hans J. Jansen
  • ,
  • Herman P. Spaink
  • ,
  • Sylvie Dufour
  • ,
  • Finn-Arne Weltzien
  • ,
  • Katsumi Tsukamoto
  • ,
  • Guido E. E. J. M. van den Thillart

7
2
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0032231
出版者・発行元
PUBLIC LIBRARY SCIENCE

The enigmatic life cycle and elongated body of the European eel (Anguilla anguilla L., 1758) have long motivated scientific enquiry. Recently, eel research has gained in urgency, as the population has dwindled to the point of critical endangerment. We have assembled a draft genome in order to facilitate advances in all provinces of eel biology. Here, we use the genome to investigate the eel's complement of the Hox developmental transcription factors. We show that unlike any other teleost fish, the eel retains fully populated, duplicate Hox clusters, which originated at the teleost-specific genome duplication. Using mRNA-sequencing and in situ hybridizations, we demonstrate that all copies are expressed in early embryos. Theories of vertebrate evolution predict that the retention of functional, duplicate Hox genes can give rise to additional developmental complexity, which is not immediately apparent in the adult. However, the key morphological innovation elsewhere in the eel's life history coincides with the evolutionary origin of its Hox repertoire.


リンク情報
DOI
https://doi.org/10.1371/journal.pone.0032231
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000302916800030&DestApp=WOS_CPL
ID情報
  • DOI : 10.1371/journal.pone.0032231
  • ISSN : 1932-6203
  • Web of Science ID : WOS:000302916800030

エクスポート
BibTeX RIS