Yoshihiko Miyata

Profile Information

Affiliation: Assistant Professor, Kyoto University

Degree: Ph. D.(The University of Tokyo)

ORCID ID: https://orcid.org/0000-0001-5359-6475
J-GLOBAL ID: 200901040945042532
researchmap Member ID: 1000259458

Research Interests

Research Areas

Research History

Education

- 1992

The University of Tokyo
- 1992

Cell & Molecular Biochemistry, Graduate School, Division of Science, The University of Tokyo
- 1988

The University of Tokyo
- 1988

Graduate School, Division of Science, The University of Tokyo
- 1986

Faculty of Science, The University of Tokyo
- 1986

Faculty of Science, The University of Tokyo

Papers

MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS

Jesús A. Pérez-Cabello, Lucía Silvera-Carrasco, Jaime M. Franco, Vivian Capilla-González, Alexandros Armaos, María Gómez-Lima, Raquel García-García, Xin Wen Yap, Magdalena Leal-Lasarte, Deepti Lall …

Proceedings of the National Academy of Sciences, 120(28), Jul 3, 2023 Peer-reviewed
Identification of FAM53C as a suppressive binding protein of a neurodevelopmental disorders-related kinase DYRK1A

Yoshihiko Miyata, Eisuke Nishida

BioRxiv, Apr 21, 2023 Lead authorCorresponding author
Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.

Yoshihiko Miyata, Eisuke Nishida

Biochimica et biophysica acta. Molecular cell research, 1868 119081-119081, Jun 17, 2021 Peer-reviewedLead authorCorresponding author
A cyclic lipopeptide surfactin is a species-selective Hsp90 inhibitor that suppresses cyanobacterial growth.

Hitoshi Nakamoto, Yuhei Yokoyama, Takahiro Suzuki, Yuri Miyamoto, Takashi Fujishiro, Masaaki Morikawa, Yoshihiko Miyata

Journal of biochemistry, 170 255-264, Mar 26, 2021 Peer-reviewedLast author
Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy.

Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, Masaru Hoshino

Biochimica et biophysica acta. Proteins and proteomics, 1867(9) 813-820, Sep, 2019 Peer-reviewed
Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity

Nakamoto, H, Amaya, Y, Komatsu, T, Suzuki, T, Dohmae, N, Nakamura, Y, Jantan, I, Miyata, Y

Biochemical Journal, 475 2559-2576, 2018 Peer-reviewedLast author
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells

Barbara Guerra, Tine D.L. Rasmussen, Alexander Schnitzler, Hans H. Jensen, Brigitte S. Boldyreff, Yoshihiko Miyata, Niels Marcussen, Karsten Niefind, Olaf-Georg Issinger

Cancer Letters, 356(2) 751-761, Jan 28, 2015 Peer-reviewed
Phosphorylation, Signaling, and Cancer: Targets and Targeting

Sandra Marmiroli, Doriano Fabbro, Yoshihiko Miyata, Mariaelena Pierobon, Maria Ruzzene

BIOMED RESEARCH INTERNATIONAL, 2015 601543, 2015 Peer-reviewedInvited
The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation

Yoshihiko Miyata, Takeshi Shibata, Masato Aoshima, Takuichi Tsubata, Eisuke Nishida

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(48) 33320-33332, Nov, 2014 Peer-reviewedLead authorLast author
The Therapeutic Target Hsp90 and Cancer Hallmarks

Yoshihiko Miyata, Hitoshi Nakamoto, Len Neckers

CURRENT PHARMACEUTICAL DESIGN, 19(3) 347-365, Jan, 2013 Peer-reviewedLead authorCorresponding author
Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells

Sofia Zanin, Christian Borgo, Cristina Girardi, Sean E. O'Brien, Yoshihiko Miyata, Lorenzo A. Pinna, Arianna Donella-Deana, Maria Ruzzene

PLOS ONE, 7(11) e49193, Nov, 2012 Peer-reviewed
Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50(CDC37)-AHA1 Chaperone Machine

Wanping Xu, Mehdi Mollapour, Chrisostomos Prodromou, Suiquan Wang, Bradley T. Scroggins, Zach Palchick, Kristin Beebe, Marco Siderius, Min-Jung Lee, Anthony Couvillon …

MOLECULAR CELL, 47(3) 434-443, Aug, 2012 Peer-reviewed
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration

Charles-Peter Xavier, Raphael H. Rastetter, Margit Bloemacher, Maria Stumpf, Mirko Himmel, Reginald O. Morgan, Maria-Pilar Fernandez, Conan Wang, Asiah Osman, Yoshihiko Miyata …

SCIENTIFIC REPORTS, 2 241-254, Jan, 2012 Peer-reviewed
Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide

Yoshihiko Miyata, Yoshihiro Yoneda, Ichiro Yahara

MOLECULAR AND CELLULAR BIOCHEMISTRY, 356(1-2) 191-200, Oct, 2011 Peer-reviewedLead authorCorresponding author
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation

Yoshihiko Miyata, Eisuke Nishida

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1813(10) 1728-1739, Oct, 2011 Peer-reviewedLead authorCorresponding author
Efficient soluble protein production on transgenic silkworms expressing cytoplasmic chaperones

Sun Mee Hong, Jun Yamashita, Hitoshi Mitsunobu, Keiro Uchino, Isao Kobayashi, Hideki Sezutsu, Toshiki Tamura, Hideki Nakajima, Yoshitaka Miyagawa, Jae Man Lee …

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 87(6) 2147-2156, Aug, 2010 Peer-reviewed
CK2: The kinase controlling the Hsp90 chaperone machinery

Y. Miyata

CELLULAR AND MOLECULAR LIFE SCIENCES, 66(11-12) 1840-1849, Jun, 2009 Peer-reviewedLead authorLast authorCorresponding author
Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

Yoshiki Tsuchiya, Makoto Akashi, Mitsuhiro Matsuda, Kyoko Goto, Yoshihiko Miyata, Koichi Node, Eisuke Nishida

SCIENCE SIGNALING, 2(73) ra26, Jun, 2009 Peer-reviewed
Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37

Yoshihiko Miyata, Eisuke Nishida

MOLECULAR AND CELLULAR BIOCHEMISTRY, 316(1-2) 127-134, Sep, 2008 Peer-reviewedLead authorCorresponding author
Hsp90

Yoshihiko Miyata

53 1062-1062, 2008 InvitedLead authorLast authorCorresponding author

Misc.

GROWTH FACTOR-INDUCED AND PHORBOL ESTER-INDUCED CHANGES IN CELL MORPHOLOGY ANALYZED BY DIGITAL IMAGE-PROCESSING

Y MIYATA, E NISHIDA, H SAKAI

CELL STRUCTURE AND FUNCTION, 12(6) 670-670, Dec, 1987
PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEINS BY PURIFIED PROTEIN-KINASE-C

M HOSHI, Y MIYATA, E NISHIDA, H SAKAI, H OGAWARA, T AKIYAMA

CELL STRUCTURE AND FUNCTION, 11(4) 447-447, Dec, 1986
BIOLOGICAL AND BIOCHEMICAL RESPONSES IN KB CELLS RAPIDLY INDUCED BY GROWTH-FACTORS .2. STIMULATION OF PINOCYTOSIS

Y MIYATA, M HOSHI, E NISHIDA, H SAKAI, T KADOWAKI, M KASUGA, S KOYASU, YAHARA, I

CELL STRUCTURE AND FUNCTION, 11(4) 454-454, Dec, 1986

Books and Other Publications

CK2 inhibitors and the DYRK family protein kinases.

Miyata, Y (Role: Joint author, 341-359)

“Protein Kinase CK2 Cellular Function in Normal and Disease States”, ed. K. Ahmed, O. Issinger, and R. Szyska, Advances in Biochemistry in Health and Disease, Springer International Publishing Switzerland, Vol. 12., 2015
The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery.

Miyata, Y (Role: Joint author, pp. 205-238)

“The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna and J. Jeffryes, Wiley-Blackwell Publishing, 2013
シグナル伝達の原理と多様性. 「医学のための細胞生物学」

宮田愛彦

南山堂, 2009 (ISBN: 4525131217)
分子生物学･免疫学キ－ワ－ド辞典第二版

宮田愛彦 (Role: Contributor, 項目担当)

医学書院, 2003
熱ショックタンパク質(HSP90・GRP94)．

宮田愛彦

廣川タンパク質化学第六巻「細胞骨格と筋肉のタンパク質」、廣川書店(東京),139-145, 1997
分子細胞生物学辞典

宮田愛彦 (Role: Contributor, 項目担当)

東京化学同人, 1997
ストレス蛋白質の機能と構造-HSP90ファミリー．

南康文, 宮田愛彦

ストレス蛋白質-基礎と臨床(永田和宏編)、中外医学社(東京),84-99, 1994
分子生物学･免疫学キ－ワ－ド辞典

宮田愛彦 (Role: Contributor, 項目担当)

医学書院, 1994
Heat shock protein (HSP).

宮田愛彦 (Role: Contributor)

免疫学用語辞典、最新医学社, 1993
Cell growth, cytoskeleton and heat shock proteins.

Yahara, I, Koyasu, S, Iida, K, Iida, H, Matsuzaki, F, Matsumoto, S, Miyata, Y (Role: Joint author, pp. 210-216)

Results and Problems in Cell Differentiation; Heat Shock and Development. (eds., L.Hightower and L.Nover), Springer-Verlag, Heidelberg,210-216, 1991
HSP90, a carrier of key proteins that regulates cell function.

Yahara, I, Miyata, Y, Minami, Y, Kimura, Y, Matsumoto, S, Koyasu, S, Yonezawa, N, Nishida, E, Sakai, H (Role: Joint author, pp. 119-122)

Heat Shock (eds., B.Maresca, and S.Lindquist), Springer-Verlag, Heidelberg, 1991

Presentations

Identification of FAM53C as a novel regulatory binding protein of DYRK1A

Yoshihiko Miyata, Eisuke Nishida

2nd International Meeting on DYRK1A, related kinases and human disease, Nov 25, 2022
Functional Regulation of Down Syndrome and Autism Spectrum Disorder-related DYRK family protein kinases

Yoshihiko Miyata

Sep 3, 2019 Invited
Hsp90 molecular chaperone, signaling protein kinases, and cancer

MIYATA, Yoshihiko

Seminar at Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (Strasbourg, France), Nov 29, 2018 Invited
Functional regulation of DYRK1A, a kinase intimately involved in Down syndrome and autism spectrum disorder, by cellular binding partners

MIYATA, Yoshihiko

Seminar at Institut de Génétique et de Biologie Moléculaire et Cellulaire (Illkirch, France), Nov 20, 2018 Invited
ダウン症関連キナーゼDYRKファミリーの細胞内結合分子シャペロンによる機能制御

宮田愛彦

埼玉大学分子生物学科セミナー (埼玉), Sep 15, 2017 Invited
Nascent chain folding process of DYRK family protein kinases

MIYATA, Yoshihiko

The 19th Symposium, Graduate School of Biostudies, Kyoto University, Jul 6, 2017 Invited
Functional regulation of different DYRK family protein kinases by distinctive cellular binding partners

MIYATA Yoshihiko

International Meeting on “DYRK1A, related kinases and human disease”, Mar 31, 2017
Mechanism of conformational transition of molecular chaperone Cdc37

Ihama, F, Yamamoto, M, Miyata, Y, Matsuzaki, K, Hoshino, M

Annual Meeting of 16th Protein Science Society of Japan, Jun 9, 2016
Essential role of TRiC/CCT chaperone in folding and function of a DYRK1A-binding WD40-repeat protein WDR68

MIYATA Yoshihiko

Dec 3, 2015
Interaction of Hsp90 and Cdc37 with specific members of the DYRK/Minibrain family protein kinases

Miyata, Y

Seminar in Semmelweis University, Department of Medical Chemistry (Budapest, Hungary), Oct 7, 2015 Invited
The Pivotal Role of A Molecular Chaperone Hsp90 for Cellular Signaling Protein Kinases

Miyata, Y

Seminar in Hungarian Academy of Sciences, Biological Research Center, Institute of Biochemistry (Szeged, Hungary), Oct 5, 2015 Invited
Essential role of TRiC/CCT in folding and function of a DYRK1A-binding WD40-repeat protein WDR68

Miyata, Y, Shibata, T, Aoshima, M, Tsubata, T, Nishida, E

Gordon Research Conference on “Stress Proteins in Growth, Development and Disease” (Lucca-Barga, Italy), Jul 5, 2015
The Pivotal Role of A Molecular Chaperone Hsp90 for Cellular Signaling Protein Kinases

MIYATA Yoshihiko

The 17th symposium, Graduate School of Biostudies, Kyoto University, Jul 2, 2015 Invited
Molecular Chaperones (Hsp90/Cdc37), Kinases, and Cancer

Miyata, Y

Vrije Universiteit Amsterdam Lecture (Kyoto, Japan), Apr 13, 2015 Invited
Molecular chaperones and cancer

Miyata, Y

Vrije Universiteit Amsterdam Lecture (Kyoto, Japan), Apr 8, 2014 Invited
DYRKファミリーキナーゼとキナーゼシグナルを媒介するWDR68

宮田愛彦

蛋白研セミナー「キナーゼ・シグナリング研究の進展」 (大阪), Mar 14, 2014 Invited
DYRKファミリーキナーゼの細胞内結合タンパク質による機能制御

宮田愛彦, 西田栄介

第36回日本分子生物学会年会ワークショップ「キナーゼ・シグナルから生理機能へ」(神戸), Dec 3, 2013 Invited
Functional regulation of DYRK family protein kinases by cellular binding partners

Miyata, Y, Nishida, E

7th International Conference on Protein Kinase CK2 (Lublin, Poland), Sep 12, 2013 Invited
Functional regulation of DYRK family protein kinases by cellular binding partners

MIYATA Yoshihiko

The 15th symposium, Graduate School of Biostudies, Kyoto University, Jul 4, 2013 Invited
Functional regulation of different DYRK family protein kinase members by distinctive cellular binding partners including Hsp90, Cdc37, and WDR68

Miyata, Y, Nishida, E

Dec 16, 2012

Professional Memberships

Major Research Projects

Analysis of physiological function of Down syndrome-associated DYRK1A-WDR68 complex.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2023

Yoshihiko Miyata

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Major Research Projects

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Coauthors