溝口洋子 (Yoko Mizoguchi) - マイポータル

基本情報

所属: 広島大学大学院医系科学研究科小児科学

J-GLOBAL ID: 201901001454753951
researchmap会員ID: B000375289

研究分野

ライフサイエンス / 血液、腫瘍内科学 /

論文

Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research

Takaki Asano, Kosuke Noma, Yoko Mizoguchi, Shuhei Karakawa, Satoshi Okada

Immunological Reviews 2023年12月12日
Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity.

Kunihiko Moriya, Tomohiro Nakano, Yoshitaka Honda, Miyuki Tsumura, Masato Ogishi, Motoshi Sonoda, Masahiko Nishitani-Isa, Takashi Uchida, Mohamed Hbibi, Yoko Mizoguchi …

The Journal of experimental medicine 220(9) 2023年9月4日
Age-specific incidence of joint disease in paediatric patients with haemophilia: A single-centre real-world outcome based on consecutive US examination.

Yoko Mizoguchi, Chihiro Tani, Mika Aizawa, Keita Tomioka, Maiko Shimomura, Shiho Nishimura, Yoshiko Matsubara, Daisuke Iwaki, Kiyoto Tanaka, Hiroshi Kawaguchi …

Haemophilia : the official journal of the World Federation of Hemophilia 29(5) 1359-1365 2023年9月
Isolated chronic mucocutaneous candidiasis due to a novel duplication variant of IL17RC.

Kosuke Noma, Miyuki Tsumura, Tina Nguyen, Takaki Asano, Fumiaki Sakura, Moe Tamaura, Yusuke Imanaka, Yoko Mizoguchi, Shuhei Karakawa, Seiichi Hayakawa …

Research square 2023年8月1日
A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis.

Fumiaki Sakura, Kosuke Noma, Takaki Asano, Kay Tanita, Etsushi Toyofuku, Kentaro Kato, Miyuki Tsumura, Hiroshi Nihira, Kazushi Izawa, Kanako Mitsui-Sekinaka …

PNAS nexus 2(4) pgad104 2023年4月
Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.

Monika I Linder, Yoko Mizoguchi, Sebastian Hesse, Gergely Csaba, Megumi Tatematsu, Marcin Łyszkiewicz, Natalia Zietara, Tim Jeske, Maximilian Hastreiter, Meino Rohlfs …

Blood 141(6) 645-658 2022年10月11日
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells.

Rui Yang, Danielle T Avery, Katherine J L Jackson, Masato Ogishi, Ibtihal Benhsaien, Likun Du, Xiaofei Ye, Jing Han, Jérémie Rosain, Jessica N Peel …

Science immunology 7(73) eabq3277 2022年7月22日
Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19.

Shohei Eto, Yoko Nukui, Miyuki Tsumura, Yu Nakagama, Kenichi Kashimada, Yoko Mizoguchi, Takanori Utsumi, Maki Taniguchi, Fumiaki Sakura, Kosuke Noma …

Journal of clinical immunology 2022年6月29日
Neutralizing Type I Interferon Autoantibodies in Japanese Patients With Severe COVID-19.

Shohei Eto, Yoko Nukui, Miyuki Tsumura, Yu Nakagama, Kenichi Kashimada, Yoko Mizoguchi, Takanori Utsumi, Maki Taniguchi, Fumiaki Sakura, Kosuke Noma …

Research square 2022年3月11日
Mendelian susceptibility to mycobacterial diseases: state-of-the-art.

Kosuke Noma, Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2022年3月10日
Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

Kiyomi Shitaoka, Yohei Kawano, Akifumi Higashiura, Yoko Mizoguchi, Takao Hashiguchi, Norihisa Nishimichi, Shiyu Huang, Ayano Ito, Akima Yamamoto, Shun Ohki …

bioRxiv 2022年1月27日
Inborn errors of STAT1 immunity

Yoko Mizoguchi, Satoshi Okada

Current Opinion in Immunology 72 59-64 2021年10月
Inherited CARD9 Deficiency in a Child with Invasive Disease Due to Exophiala dermatitidis and Two Older but Asymptomatic Siblings

Yusuke Imanaka, Maki Taniguchi, Takehiko Doi, Miyuki Tsumura, Rie Nagaoka, Maiko Shimomura, Takaki Asano, Reiko Kagawa, Yoko Mizoguchi, Shuhei Karakawa …

Journal of Clinical Immunology 41(5) 975-986 2021年7月
Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ.

Miyuki Tsumura, Mizuka Miki, Yoko Mizoguchi, Osamu Hirata, Shiho Nishimura, Moe Tamaura, Reiko Kagawa, Seiichi Hayakawa, Masao Kobayashi, Satoshi Okada

The Journal of allergy and clinical immunology 149(1) 252-261 2021年6月17日
Mammalian VPS45 orchestrates trafficking through the endosomal system

Laura Frey, Natalia Ziętara, Marcin Łyszkiewicz, Benjamin Marquardt, Yoko Mizoguchi, Monika I. Linder, Yanshan Liu, Florian Giesert, Wolfgang Wurst, Maik Dahlhoff …

Blood 2021年4月8日
【原発性免疫不全症候群-最新の疾患分類と新規疾患を中心に-】内因性あるいは自然免疫の異常 Epidermodysplasia verruciformis(HPV) CIB1欠損症

溝口洋子, 岡田賢

日本臨床 78(増刊7 原発性免疫不全症候群) 325-327 2020年12月
Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutations.

Sonoko Sakata, Miyuki Tsumura, Tadashi Matsubayashi, Shuhei Karakawa, Shunsuke Kimura, Moe Tamaura, Tsubasa Okano, Takuya Naruto, Yoko Mizoguchi, Reiko Kagawa …

International immunology 32(10) 663-671 2020年6月30日査読有り
IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation

Nishimura, S., Kobayashi, Y., Ohnishi, H., Moriya, K., Tsumura, M., Sakata, S., Mizoguchi, Y., Takada, H., Kato, Z., Sancho-Shimizu, V. …

Journal of Clinical Immunology 41(1) 125-135 2020年
Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells.

Eken A, Cansever M, Somekh I, Mizoguchi Y, Zietara N, Okus FZ, Erdem S, Canatan H, Akyol S, Ozcan A …

Journal of clinical immunology 39(4) 391-400 2019年5月査読有り
Neutropenia (In infancy and childhood)

Masao Kobayashi, Yoko Mizoguchi, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi

Hematological Disorders in Children: Pathogenesis and Treatment 109-113 2017年6月14日査読有り

もっとみる

MISC

Proteotypic Imbalances in Neutrophil Granulocytes with Monogenic Disorders Associated with Congenital Neutropenia

Yoko Mizoguchi, Sebastian Hesse, Monika Linder, Piotr Grabowsky, Juri Rappsilber, Masao Kobayashi, Christoph Klein

PEDIATRIC BLOOD & CANCER 67 2020年12月
Congenital Neutropenia Caused by SRP54 Mutations

Ayaka Suzawa, Shuhei Krakawa, Satoshi Okada, Satoshi Saito, Shiho Nishimura, Yoshiyuki Kobayashi, Yoko Mizoguchi, Takehiko Doi, Hiroshi Kawaguchi, Chihaya Imai …

PEDIATRIC BLOOD & CANCER 66 S48-S48 2019年12月
Defects in Signal Recognition Particle (SRP) Components Reveal an Essential and Non-Redundant Role for Granule Biogenesis and Differentiation of Neutrophil Granulocytes

Yoko Mizoguchi, Sebastian Hesse, Monika Linder, Natalia Zietara, Marcin Lyszkiewicz, Yanshan Liu, Megumi Tatematsu, Piotr Grabowski, Kaarin Ahomaa, Tim Jeske …

BLOOD 134 2019年11月
The Efficacy of Ultrasound Joint Examination for the Detection of Arthropathy in Patients with Hemophilia

Shiho Nishimura, Keita Tomioka, Maiko Shimomura, Yoko Mizoguchi, Shinobu Sasaki, Masao Kobayashi

PEDIATRIC BLOOD & CANCER 65 S68-S68 2018年11月
The Efficiacy of Ultrasound Joint Examination for the Management in Patients with Hemophilia

Shiho Nishimura, Keita Tomioka, Maiko Shimomura, Yoko Mizoguchi, Shinobu Sasaki, Chihiro Tani, Yoshiko Matsubara, Kazuo Awai, Yuko Nakashima, Nobuo Adachi …

BLOOD 132 2018年11月
Pharmacokinetics Using myPKFiT(R) for Personalized Prophylaxis in Children with Severe Hemophilia a.

Shiho Nishimura, Keita Tomioka, Maiko Shimomura, Yoko Mizoguchi, Masao Kobayashi

BLOOD 130 2017年12月
A Case with Paroxysmal Nocturnal Hemoglobinuria with Long-term Remission Due to Immunosuppressive Therapy

Takehiko Doi, Hiroshi Kawaguchi, Yoko Mizoguchi, Shiho Nishimura, Shuhei Karakawa, Satoshi Okada, Masao Kobayashi

PEDIATRIC BLOOD & CANCER 64 S111-S111 2017年11月
Long-term Follow-up of Patients with Chronic Granulomatous Disease Undergoing (Receiving) Bone Marrow Transplantation

Masao Kobayashi, Shiho Nishimura, Yoko Mizoguchi, Mizuka Miki, Shuhei Karakawa, Takehiko Doi, Satoshi Okada, Hiroshi Kawaguchi

PEDIATRIC BLOOD & CANCER 64 S20-S21 2017年11月
Successful Bone Marrow Transplantation in 13 Patients with Severe Congenital Neutropenia

Shiho Nishimura, Yoko Mizoguchi, Aya Furue, Maiko Shimomura, Shuhei Karakawa, Takehiko Doi, Shinji Mochizuki, Satoshi Okada, Hiroshi Kawaguchi, Kobayashi Masao

PEDIATRIC BLOOD & CANCER 64 S75-S75 2017年11月
Successful Hematopoietic Stem Cell Transplantation Using an Immunosuppressive Conditioning Regimen in Ten Patients with Severe Congenital Neutropenia: A Single-Institute Experience

Yoko Mizoguchi, Mizuka Miki, Aya Furue, Shiho Nishimura, Maiko Shimomura, Keita Tomioka, Sonoko Sakata, Ikue Chijimatsu, Shuhei Karakawa, Satoshi Okada …

BLOOD 128(22) 2016年12月
SUCCESSFUL HEMATOPOIETIC STEM CELL TRANSPLANTATION IN TEN PATIENTS WITH SEVERE CONGENITAL NEUTROPENIA USING AN INTENSIVE IMMUNOMYELOSUPPRESSIVE CONDITIONING REGIMEN: THE RESULTS OF A SINGLE INSTITUTE

Y. Mizoguchi, S. Karakawa, T. Doi, M. Shimomura, K. Tomioka, S. Sakata, A. Furue, I. Chijimatsu, S. Okada, M. Miki …

HAEMATOLOGICA 101 336-337 2016年6月
Colonic Manifestations of Chronic Granulomatous Disease

Shintaro Sagami, Shinji Tanaka, Yoshitaka Ueno, Kenta Nagai, Ryohei Hayashi, Shiro Oka, Masanori Ito, Yasuhiko Kitadai, Mizuka Miki, Takehiko Doi …

GASTROINTESTINAL ENDOSCOPY 83(5) AB307-AB307 2016年5月
MSMD Patients with IFN-g-STAT1 Signaling Defect Present Enhanced Osteoclastogenesis and Bone Resorption

Shiho Nishimura, Miyuki Tsumura, Osamu Hirata, Reiko Kagawa, Yoko Mizoguchi, Satoshi Okada, Masao Kobayashi

BLOOD 126(23) 2015年12月
免疫不全―17 好中球減少症および白血球接着異常症

小林正夫, 溝口洋子, 岡田賢

小児内科 47 736-745 2015年11月30日
当科における最近6年間の悪性腹部腫瘍症例の検討

土居岳彦, 松原千春, 下村麻衣子, 郷田聡, 今中雄介, 溝口洋子, 唐川修平, 岡田賢, 三木瑞香, 川口浩史 …

広島医学 68(6) 362 2015年6月28日
Successful Retransplantation of Bone Marrow Cells Following Failure of Initial Engraftment in 4 Patients with SCN

Shiho Nishimura, Yoko Mizoguchi, Shuhei Karakawa, Keita Tomioka, Mizuka Miki, Hiroshi Kawaguchi, Kazuhiro Nakamura, Masao Kobayashi

BLOOD 124(21) 2014年12月
Early elimination of Factor VIII inhibitor by ITI with high dose immunoglobulin in children with hemophilia A

Yoko Mizoguchi, Aya Furue, Ikue Chijimatsu, Mizuka Miki, Keita Tomioka, Nakao Konishi, Atsushi Ono, Hiroshi Kawaguchi, Kazuhiro Nakamura, Masao Kobayashi

HAEMOPHILIA 20 46-46 2014年5月
重症先天性好中球減少症の病態解析研究の進歩

溝口洋子, 小林正夫

血液内科 68(5) 676-681 2014年5月
原発性免疫不全症候群に関する調査研究 STAT1機能獲得性変異によるCMCD患者の迅速診断法の確立

岡田賢, 溝口洋子, 津村弥来, 平田修, 小林正夫

原発性免疫不全症候群に関する調査研究平成25年度総括・分担研究報告書 51-55 2014年
原発性免疫不全症に対する造血幹細胞移植法の確立食細胞異常症における効果的造血幹細胞移植

小林正夫, 溝口洋子, 唐川修平, 岡田賢, 三木瑞香, 川口浩史

原発性免疫不全症に対する造血幹細胞移植法の確立平成25年度総括・分担研究報告書 49-52 2014年

もっとみる

講演・口頭発表等

重症先天性好中球減少症16例に対して有効であった骨髄移植

西村志帆, 溝口洋子, 古江綾, 冨岡啓太, 坂田園子, 下村麻衣子, 谷口真紀, 森下祐介, 加藤豊, 松村梨紗, 唐川修平, 三木瑞香, 土居岳彦, 望月慎史, 岡田賢, 川口浩史, 小林正夫

日本小児科学会雑誌 2019年2月 (公社)日本小児科学会
食細胞異常症に対する骨髄移植

小林正夫, 土居岳彦, 唐川修平, 下村麻衣子, 望月慎史, 三木瑞香, 溝口洋子, 西村志帆, 岡田賢, 川口浩史

日本小児科学会雑誌 2018年2月 (公社)日本小児科学会
A Comparison of Myelopoiesis from Induced Pluripotent Stem Cells with a Mutation in ELANE between Cyclic Neutropenia and Severe Congenital Neutropenia

Saito Satoshi, Nishimura Shiho, Tsumura Miyuki, Mizoguchi Yoko, Sakata Sonoko, Furue Aya, Miki Mizuka, Kawaguchi Hiroshi, Hiramoto Takafumi, Ebihara Yasuhiro, Tsuji Kohichiro, Nakahata Tatsutoshi, Kobayashi Masao

BLOOD 2015年12月3日
MSMD Patients with IFN-g-STAT1 Signaling Defect Present Enhanced Osteoclastogenesis and Bone Resorption

Nishimura Shiho, Tsumura Miyuki, Hirata Osamu, Kagawa Reiko, Mizoguchi Yoko, Okada Satoshi, Kobayashi Masao

Blood 2015年
STAT1 Gain-of-Function in Patients with Chronic Mucocutaneous Candidiasis Can be Detected By the Excessive Phosphorylation of STAT1 in Peripheral Blood Monocytes

Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada, Osamu Hirata, Shizuko Minegishi, Nobuyuki Hyakuna, Jean-Laurent Casanova, Tomohiro Morio, Masao Kobayashi

BLOOD 2014年12月 AMER SOC HEMATOLOGY
GAIN-OF-FUNCTION MUTATIONS OF STAT1 IN JAPANESE PATIENTS WITH CMCD

Hirata O, Tsumura M, Mizoguchi Y, Okada S, Minegishi S, Morio T, Kobayashi M

Journal of Clinical Immunology 2012年
Gain-of-Phosphorylation Mutations in Coiled-Coil and DNA-Binding Domain of STAT1 Identified in Japanese Patients with Chronic Mucocutaneous Candidiasis

Mizoguchi Yoko, Okada Satoshi, Tsumura Miyuki, Hirata Osamu, Casanova Jean-Laurent, Morio Tomohiro, Kobayashi Masao

Blood 2012年
A Novel Mutation K673R In STAT1 Impaired the STAT1 Signal Transduction In a dominant- Negative Manner Identified In a Japanese Boy with MSMD

Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada, Hidemasa Sakai, Ryuta Nishikomori, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Takuji Murata, Hideto Obata, Takahiro Yasumi, Toshio Heike, Tatsutoshi Nakahata, Yoshihiro Takihara, Masao Kobayashi

BLOOD 2010年11月 AMER SOC HEMATOLOGY
Decreased Expression In NF-kappa B Essential Modulator Due to a Novel Splice-Site Mutation Causes Ectodermal Dysplasia with Immunodeficiency

Karakawa Shuhei, Okada Satoshi, Tsumura Miyuki, Mizoguchi Yoko, Ohno Norioki, Yasunaga Shin'ichiro, Ohtsubo Motoaki, Kawai Tomolci, Nishikomori Ryuta, Takihara Yoshihiro, Kobayashi Masao

Blood 2010年
A Novel Splicing Mutation in NEMO Gene in a Patient with X-Linked Ectodermal Dysplasia with Immunodeficiency

Karakawa Syuhei, Okada Satoshi, Tsumura Miyuki, Mizoguchi Yoko, Kawai Tomoki, Nishikomori Ryota, Yasunaga Shin'ichiro, Takihara Yoshihiro, Kobayashi Masao

Blood 2009年

共同研究・競争的資金等の研究課題

ウイルスに対する易感染性に着目した原発性免疫不全症の病因病態解明

日本学術振興会科学研究費助成事業基盤研究(B) 2022年4月 - 2025年3月

岡田賢, 小原收, 溝口洋子, 津村弥来
プロテオーム解析に基づいた先天性好中球減少症における小胞体ストレス発症機構の解明

日本学術振興会科学研究費助成事業若手研究 2021年4月 - 2023年3月

溝口洋子
疾患特異的iPS細胞を利用した先天性好中球減少の病態解明と新規治療薬探索

日本学術振興会科学研究費助成事業若手研究(B) 2015年4月 - 2016年3月

溝口洋子

溝口洋子

基本情報

研究分野

論文

MISC

講演・口頭発表等

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧