2014年3月
ROLE OF EXERCISE IN MAINTAINING THE INTEGRITY OF THE NEUROMUSCULAR JUNCTION
MUSCLE & NERVE
- ,
- ,
- 巻
- 49
- 号
- 3
- 開始ページ
- 315
- 終了ページ
- 324
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/mus.24095
- 出版者・発行元
- WILEY-BLACKWELL
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin-1, peroxisome proliferator-activated receptor gamma coactivator 1, insulin-like growth factor-1, glial cell line-derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age-dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve49:315-324, 2014
- リンク情報
- ID情報
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- DOI : 10.1002/mus.24095
- ISSN : 0148-639X
- eISSN : 1097-4598
- Web of Science ID : WOS:000331999300003