論文

査読有り 国際誌
2019年12月19日

Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report.

BMC veterinary research
  • Masamichi Yamashita
  • ,
  • Tomohiro Osaki
  • ,
  • Yusuke Murahata
  • ,
  • Yuji Sunden
  • ,
  • Rinko Morita
  • ,
  • Tomohiro Imagawa
  • ,
  • Yoshiharu Okamoto

15
1
開始ページ
459
終了ページ
459
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12917-019-2213-1

BACKGROUND: Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medicine have been scarse. Moreover, only one case of intradural extramedullary IPT has been previously reported. In this report, we introduce the first known case of canine IPT, which occurred in the parenchyma of the spinal cord. CASE PRESENTATION: A 10-year-old female Miniature Dachshund presented with a 2-month-long history of progressively worsening ataxia and tetraparesis. Neurological examination was consistent with a lesion involving the cervical spinal cord. Magnetic resonance imaging revealed an intradural space-occupying lesion in the region of the fourth cervical vertebra. Dorsal laminectomy and resection of the mass were performed. Histopathological examination revealed the proliferation of immature spindle cells (fibroblasts/myofibroblasts and glial cells) and a highly cellular mixture of neutrophils, macrophages and lymphocytic cells. The mass was located in the parenchyma of the spinal cord and was diagnosed as an IPT occurring in the parenchyma of the spinal cord. No causative pathogen was detected. The dog's symptoms improved, during the first month after surgery. However, neurological symptoms, such as laboured breathing and dysuria, subsequently worsened and the dog died 42 days after surgery. CONCLUSIONS: The present study describes a canine case of IPT occurring in the parenchyma of the spinal cord. The diagnosis and determination of the site of the mass was difficult solely based on preoperative imaging in the present case. The outcome of this case was poorer than that observed in cases of canine extramedullary IPT and human intramedullary IPT, in which the patients exhibited recovery. The prognosis after surgical resection cannot be decided from the present case alone. However, patients should be monitored for potential serious complications and recurrence.

リンク情報
DOI
https://doi.org/10.1186/s12917-019-2213-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31856853
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921595
ID情報
  • DOI : 10.1186/s12917-019-2213-1
  • PubMed ID : 31856853
  • PubMed Central 記事ID : PMC6921595

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