論文

査読有り 国際誌
2018年9月

Use of ozonated water as a new therapeutic approach to solve current concerns around antitumor treatment.

Experimental and therapeutic medicine
  • Kohei Kuroda
  • ,
  • Masamiti Yamashita
  • ,
  • Yusuke Murahata
  • ,
  • Kazuo Azuma
  • ,
  • Tomohiro Osaki
  • ,
  • Takeshi Tsuka
  • ,
  • Norihiko Ito
  • ,
  • Tomohiro Imagawa
  • ,
  • Yoshiharu Okamoto

16
3
開始ページ
1597
終了ページ
1602
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/etm.2018.6415

Tumor hypoxia is a severe problem affecting tumor therapy because it reduces the sensitivity of chemotherapy and radiation therapy. Ozone has been known to improve peripheral blood perfusion and oxygen partial pressure. The effect of ozonated water on tumor hypoxia, alone and in combination with an antitumor drug was studied in the present study. Following intraperitoneal administration of ozonated water to colon-26-bearing mice, the Hoechst 33342-positive area and the intratumoral oxygen partial pressure was significantly increased. The tumor growth rate was more suppressed when ozonated water was combined with cisplatin (CDDP) compared with CDDP treatment alone. The number of Ki-67-positive cells significantly decreased, whereas the number of TUNEL-positive cells significantly increased. The present study showed that ozonated water increased intratumoral blood perfusion and improved tumor hypoxia. In addition, ozonated water increased the therapeutic effect of CDDP. These findings, as well as previous reports, suggest that tumor growth is suppressed after treatment with ozonated water as the amount of CDDP reaching the tumor is increased when the intratumoral blood perfusion is increased due to the ozonated water. Thus, the administration of ozonated water may be a new therapeutic approach to solve current concerns regarding antitumor treatment.

リンク情報
DOI
https://doi.org/10.3892/etm.2018.6415
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30186377
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122405
ID情報
  • DOI : 10.3892/etm.2018.6415
  • PubMed ID : 30186377
  • PubMed Central 記事ID : PMC6122405

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