論文

査読有り
2018年7月12日

The effect of remifentanil on the minimum alveolar concentration (MAC) and MAC derivatives of sevoflurane in dogs.

The Journal of veterinary medical science
  • Yusuke Murahata
  • ,
  • Yoshiaki Hikasa
  • ,
  • Sho Hayashi
  • ,
  • Koki Shigematsu
  • ,
  • Natsuki Akashi
  • ,
  • Tomohiro Osaki
  • ,
  • Takeshi Tsuka
  • ,
  • Yoshiharu Okamoto
  • ,
  • Tomohiro Imagawa

80
7
開始ページ
1086
終了ページ
1093
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.18-0122

Remifentanil is an ultra-short-acting µ-opioid receptor agonist. The purpose of this study was to determine the relationship of the minimum alveolar concentration (MAC) of sevoflurane and other MAC derivatives, including the MAC for blocking adrenergic responses (MAC-BAR) and the MAC at which tracheal extubation is occurred (MAC-extubation), with or without remifentanil infusion. Six healthy adult beagle dogs were randomly anesthetized three times for determining the MAC-BAR (SEVMAC-BAR), MAC (SEVMAC), and MAC- extubation (SEVMAC-extubation) of sevoflurane under infusion of saline and remifentanil at rates of 0.15, 0.30, 0.60, 1.20, and 2.40 µg/kg/min. The ratio of the SEVMAC-BAR and SEVMAC and that of the SEVMAC-extubation and SEVMAC were not significantly different at baseline and during treatment. The MAC-BAR95 and MAC95 decreased in a dose-dependent manner until reaching 1.20 µg/kg/min, and the MAC-extubation5 decreased in a dose-dependent manner until reaching 0.60 µg/kg/min. The percentage reduction of SEVMAC-BAR, SEVMAC, and SEVMAC-extubation increased in a dose-dependent manner during remifentanil infusion. The heart rate significantly decreased in the MAC-BAR and MAC groups, and the systolic and mean arterial pressures increased after remifentanil infusion compared with the baseline values. Remifentanil infusion caused reduction of the SEVMAC-BAR, SEVMAC, and SEVMAC-extubation in a dose-dependent manner, and ceiling effects were observed in the dogs. Higher doses of remifentanil and sevoflurane were necessary for blocking the sympathetic response to the supramaximal stimulus to prevent movement and extubation in dogs.

リンク情報
DOI
https://doi.org/10.1292/jvms.18-0122
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29780077
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068302
ID情報
  • DOI : 10.1292/jvms.18-0122
  • PubMed ID : 29780077
  • PubMed Central 記事ID : PMC6068302

エクスポート
BibTeX RIS