論文

査読有り 国際誌
2017年2月

Analysis of plasma free amino acid profiles in canine brain tumors.

Biomedical reports
  • Shinichi Utsugi
  • ,
  • Kazuo Azuma
  • ,
  • Tomohiro Osaki
  • ,
  • Yusuke Murahata
  • ,
  • Takeshi Tsuka
  • ,
  • Norihiko Ito
  • ,
  • Tomohiro Imagawa
  • ,
  • Yoshiharu Okamoto

6
2
開始ページ
195
終了ページ
200
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/br.2016.825

Canine brain tumors are best diagnosed using magnetic resonance imaging (MRI). However, opportunities of MRI examination are restricted due to its limited availability in veterinary facilities; thus, numerous canine brain tumors are diagnosed at an advanced stage. Therefore, development of a noninvasive diagnostic biomarker is required for the early detection of brain tumors. In the present study, plasma free amino acid (PFAA) profiles between dogs with and without brain tumors were compared. A total of 12 dogs with brain tumors, diagnosed based on clinical signs, and on the results of intracranial MRI and/or pathological examination were evaluated. In addition, eight dogs diagnosed with idiopathic epilepsy and 16 healthy dogs were also included. A liquid chromatography system with automated pre-column derivatization functionality was used to measure the levels of 20 amino acids. As a result, the levels of three amino acids (alanine, proline and isoleucine) were increased significantly (1.6-, 1.5- and 1.6-fold, respectively) in the plasma of dogs with brain tumors as compared with the levels in control dogs (all P<0.05). Thus, the PFAA levels of dogs with brain tumors differed from those of healthy dogs. The present study demonstrated that analysis of PFAA levels of dogs with brain tumors may serve as a useful biomarker for the early detection of canine brain tumors.

リンク情報
DOI
https://doi.org/10.3892/br.2016.825
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28357072
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351192
ID情報
  • DOI : 10.3892/br.2016.825
  • PubMed ID : 28357072
  • PubMed Central 記事ID : PMC5351192

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