Yukihiro Nakamura

Profile Information

Affiliation: Assistant Professor, Department of Pharmacology, Jikei University

Other name(s) (e.g. nickname): Yukihiro Nakamura
Researcher number: 40460696
ORCID ID: https://orcid.org/0000-0002-8820-7780
J-GLOBAL ID: 201401094327805099
researchmap Member ID: B000240815

External link: http://www.jikei-pharm.com/

I investigate presynaptic mechanisms for synaptic transmission in the central nervous system using patch-clamp technique and optical measurements combined with numerical simulations.

Research Areas

Papers

GABA B receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles

Peter Koppensteiner, Pradeep Bhandari, Cihan Önal, Carolina Borges-Merjane, Elodie Le Monnier, Utsa Roy, Yukihiro Nakamura, Tetsushi Sadakata, Makoto Sanbo, Masumi Hirabayashi …

Proceedings of the National Academy of Sciences, Feb 20, 2024 Peer-reviewed
研究者の最新動向脊髄小脳失調症新規モデルマウスを用いた病態解析

土井宏, 橋口俊太, 中村行宏, 石川太郎, 田中章景

Precision Medicine, 2(13) 1260-1266, Dec, 2019
EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels.

Nakamura Y

Frontiers in synaptic neuroscience, 11(26), Oct, 2019 Peer-reviewedLead authorLast authorCorresponding author
Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42.

Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina …

Neurobiology of disease, 130 104516-104516, Oct, 2019 Peer-reviewed
Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules

Fekete, A., Nakamura, Y., Yang, Y.-M., Herlitze, S., Mark, M.D., DiGregorio, D.A., Wang, L.-Y.

Nature Communications, 10(1) 826, Feb 18, 2019 Peer-reviewed
Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses

Miki, T., Nakamura, Y., Malagon, G., Neher, E., Marty, A.

Nature Communications, 9(1) 3943, Sep 26, 2018 Peer-reviewed
Variations in Ca²⁺influx can alter chelator-based estimates of Ca²⁺channel–synaptic vesicle coupling distance

Nakamura, Y., Reva, M., Digregorio, D.A.

Journal of Neuroscience, 38(16) 3971-3987, Apr 18, 2018 Peer-reviewedLead authorCorresponding author
Ca2+ Channel to Synaptic Vesicle Distance Accounts for the Readily Releasable Pool Kinetics at a Functionally Mature Auditory Synapse

Zuxin Chen, Brati Das, Yukihiro Nakamura, David A. DiGregorio, Samuel M. Young

JOURNAL OF NEUROSCIENCE, 35(5) 2083-2100, Feb, 2015 Peer-reviewed
Nanoscale Distribution of Presynaptic Ca2+ Channels and Its Impact on Vesicular Release during Development

Yukihiro Nakamura, Harumi Harada, Naomi Kamasawa, Ko Matsui, Jason S. Rothman, Ryuichi Shigemoto, R. Angus Silver, David A. DiGregorio, Tomoyuki Takahashi

NEURON, 85(1) 145-158, Jan, 2015 Peer-reviewedLead author
Disruption of the Ether-a-go-go K+ Channel Gene BEC1/KCNH3 Enhances Cognitive Function

Akira Miyake, Shinji Takahashi, Yukihiro Nakamura, Kohei Inamura, Shun-ichiro Matsumoto, Shinobu Mochizuki, Masao Katou

JOURNAL OF NEUROSCIENCE, 29(46) 14637-14645, Nov, 2009 Peer-reviewedLead author
Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal

Yukihiro Nakamura, Tomoyuki Takahashi

JOURNAL OF PHYSIOLOGY-LONDON, 581(3) 1101-1112, Jun, 2007 Peer-reviewedLead author
G protein-dependent presynaptic inhibition mediated by AMPA receptors at the calyx of Held

H Takago, Y Nakamura, T Takahashi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(20) 7368-7373, May, 2005 Peer-reviewedLead author
Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal

T Ishikawa, Y Nakamura, N Saitoh, WB Li, S Iwasaki, T Takahashi

JOURNAL OF NEUROSCIENCE, 23(32) 10445-10453, Nov, 2003 Peer-reviewed
Localization of phospholipase C beta isozymes in the mouse cerebellum

T Sugiyama, M Hirono, K Suzuki, Y Nakamura, A Aiba, K Nakamura, K Nakao, M Katsuki, T Yoshioka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 265(2) 473-478, Nov, 1999 Peer-reviewed
Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A

Y Kishimoto, S Kawahara, Y Kirino, H Kadotani, Y Nakamura, M Ikeda, T Yoshioka

NEUROREPORT, 8(17) 3717-3721, Dec, 1997 Peer-reviewed

Misc.

脳科学辞典「カルシウムキレート剤」

中村行宏, 高橋智幸

Jul, 2018 Peer-reviewedLead author
脳科学辞典「Held萼状シナプス」

中村行宏, 高橋智幸

Oct, 2016 Peer-reviewedLead author

Books and Other Publications

ラング・デール薬理学原書8版

渡邊直樹 (Role: Joint translator, 37-38章)

丸善出版, Dec, 2018 (ISBN: 9784621301708)
脳・神経科学の研究ガイド

Carter, Matt, Shieh, Jennifer C., 小島, 比呂志, 中村, 行宏, 二見, 高弘

朝倉書店, Feb 10, 2013 (ISBN: 9784254102598)
Patch-clamp recording method in slices for studying presynaptic mechanisms

Tomoyuki Takahashi, Tetsuya Hori, Yukihiro Nakamura, Takayuki Yamashita

Jan, 2012
最新パッチクランプ実験技術法

岡田泰伸編 (Role: Contributor)

吉岡書店, May, 2011 (ISBN: 9784842703589)

Presentations

EGTA can inhibit vesicular release in the 'nanodomain' distance from Ca channels

Yukihiro Nakamura

IBRO2019, Sep 24, 2019
Ca2+ gradients at the vicinity of the Ca2+ channel: a comparison between linearized buffer approximation and reaction-diffusion simulation

Yukihiro Nakamura, David DiGregorio

The 41st Annual Meeting of the Japan Neuroscience Society, Jul 26, 2018
The estimate of spatial distribution of readily-releasable vesicles at a central presynaptic terminal

Yukihiro Nakamura, Tetsuya Hori

The 95th Annual Meeting of the Physiological Society Meeting, Mar 29, 2018
Inhibition of nanodomain Ca-driven vesicular release by EGTA

Yukihiro Nakamura, Testuya Hori

The 40th Annual Meeting of the Japan Neuroscience Society, Jul 20, 2017
EGTAによるナノドメインCaの抑制

中村行宏

生理学研究所研究会「シナプス伝達の細胞分子調節機構」, Nov 22, 2016
Ca2+ entry duration determines effective coupling distance between Ca2+ channels and synaptic vesicles

Yukihiro Nakamura, David DiGregorio

The 39th Annual Meeting of Japan Neuroscience Society, Jul 20, 2016
0

Synaptic vesicle distance from Ca2; channel cluster perimeter determines the time course of transmitter release at the calyx of Held

Nakamura Y, Rothman J, Chen Z, Das B, Silver RA, Takahashi T, Young SM, DiGregorio D

The 37th annual meeting of the Japan Neuroscience Society, Sep 12, 2014
0

Multiple Ca channels mediate fast synaptic transmission in CNS of matured animal

Nakamura Y, Harada H, Kamasawa N, Matsui K, Shigemoto R, Rothman J, Silver RA, DiGregorio D, Takahashi T

The 35th annual meeting of the Japan Neuroscience Society, Sep 19, 2012
0

Developmental changes in spatial profiles of Ca channel and Ca influx underlying tightening of Ca-secretion coupling at the calyx of Held

Nakamura Y, Harada H, Kamasawa N, Matsui K, Shigemoto R, Rothman J, Silver RA, DiGregorio D, Takahashi T

CNRS Conférences Jacques Monod, Jul 2, 2012
Developmental changes in presynaptic Ca2+ signaling at the calyx of Held

Nakamura Y

Physical Concepts of Medical Science, May 18, 2012 Invited
0

Developmental changes in the spatial distribution of Ca2+ signals at the calyx of Held

Nakamura Y

OIST symposium "Molecular & Structural Organization of Presynaptic Function and Plasticity", Sep 8, 2011
Selective involvement of the ether-à-go-go K+ channel BEC1/KCNH3 in cognitive function.

Takahashi S, Nakamura Y, Inamura K, Miyake A

Annual meeting of Society for Neuroscience 2010, Nov 15, 2010
0

シナプス前終末における伝達物質放出機構-Ca結合の生後発達変化

中村行宏, Silver RA, DiGregorio D, 高橋智幸

生理学研究所シナプス研究会, Nov 12, 2009
0

Developmental reduction in functional Ca2+ channel density tightens Ca2+-secretion coupling at a central excitatory synapse

Nakamura Y, DiGregorio D, Silver RA, Takahashi T

Annual meeting of Society for Neuroscience 2009, Oct 19, 2009
0

シナプス終末におけるCaドメインの生後発達変化

中村行宏, DiGregorio D, Silver RA, 高橋智幸

生理学研究所研究会, Oct 2, 2008
Developmental shrinkage of Ca2+ domain size at the calyx of Held presynaptic terminal

Nakamura Y, DiGregorio D, Takahashi T

The 85th Annual Meeting of the Physiological Society Japan, Mar 27, 2008
Single action potential-evoked Ca2+ transients at the calyx of Held presynaptic terminal

Nakamura Y, DiGregorio D, Takahashi T

Neuro2007, Sep, 2007
Developmental changes in potassium currents at the calyx of Held presynaptic terminal

Nakamura Y, Takahashi T

The 84th Annual Meeting of the Physiological Society Japan, Mar 21, 2007
生後発達に伴う前シナプス活動電位変化のメカニズム

中村行宏, 高橋智幸

生理学研究所シナプス研究会, Nov 26, 2004
Mechanisms underlying developmental shortening of presynaptic action potential at the calyx of Held

Nakamura Y, Ishikawa T, Takahashi T

Annual meeting of Society for Neuroscience 2004, Oct, 2004

Teaching Experience

2016 - Present

生体と薬物（薬理学） (東京慈恵会医科大学)
機能系実習「薬理学系」 (東京慈恵会医科大学)

Professional Memberships

Research Projects

Study on the spatio-temporal dynamics of calcium and glutamate coupling at sensory ribbon synapses.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Elucidation of Ca sparks in CNS presynaptic terminals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
シナプスの短期可塑性を制御する即時放出可能シナプス小胞の空間分布の解明

科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2017 - Mar, 2020

中村行宏
Developmental changes in Ca channel density and single channel conductance at the presynaptic terminal of central nervous system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2011 - 2012

NAKAMURA Yukihiro
Developmental changes in calcium domain at the presynaptic terminal of the central synapse

Grants-in-Aid for Scientific Research(若手研究(B)), 若手研究(B), Ministry of Education, Culture, Sports, Science and Technology, Apr, 2008 - Mar, 2010

Yukihiro NAKAMURA

Industrial Property Rights

PCT/JP2002/011843 Transgenic animals

Akira Miyake, Yukihiro Nakamura, Jianwei Ni, Shinobu Mochizuki

Profile Information

Research Interests

Research Areas

Papers

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Books and Other Publications

Presentations

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Research Projects

Industrial Property Rights

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