南雲康行 (Nagumo Yasuyuki) - 論文

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine (in press)

Yasuyuki Nagumo, Koki Katoh, Keita Iio, Tsuyoshi Saitoh, Noriki Kutsumura, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takeshi Baba, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase

2020年6月査読有り

Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations

Yasuyuki Nagumo, Yoshifumi Ueta, Hisako Nakayama, Hironobu Osaki, Yuichi Takeuchi, Naofumi Uesaka, Masanobu Kano, Mariko Miyata

Cell Reports 31(12) 107797 - 107797 2020年6月査読有り

Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities

Noriki Kutsumura, Yasuaki Koyama, Tsuyoshi Saitoh, Naoshi Yamamoto, Yasuyuki Nagumo, Yoshiyuki Miyata, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ōmura, Hiroshi Nagase

Molecules 2020年3月査読有り

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.

Tsuyoshi Saitoh, Kazunori Seki, Ryo Nakajima, Naoshi Yamamoto, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase

Bioorganic & medicinal chemistry letters 30(3) 126893 - 126893 2020年2月1日査読有り

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

Bioorganic & medicinal chemistry letters 29(18) 2655 - 2658 2019年9月

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H

Bioorganic & medicinal chemistry letters 29(18) 2655 - 2658 2019年9月査読有り

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase

Bioorganic and Medicinal Chemistry 27 1747 - 1758 2019年4月15日

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi

Bioorganic & medicinal chemistry 27(8) 1747 - 1758 2019年4月

A novel rearrangement reaction of morphinan to arylmorphan skeletons and the pharmacologies of arylmorphan derivatives.

Yata M, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y, Yamagisawa M, Nagase H

HETEROCYCLES 99(1) 134 - 144 2019年査読有り

SYNTHESIS OF NOVEL 1,3-DIOXA-5-THIAZATRIQUINANE AND 1-OXA-3,5-DITHIAZATRIQUINANE DERIVATIVES AND THEIR PHARMACOLOGIES

Ohshita R, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Hirayama S, Fujii H, Nagase H

Heterocycles 97(2) 687 - 695 2018年4月2日査読有り

Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton

Noriki Kutsumura, Yasuaki Koyama, Yuko Suzuki, Ken-Ichi Tominaga, Naoshi Yamamoto, Tsuyoshi Saitoh, Yasuyuki Nagumo, Hiroshi Nagase

Organic Letters 20(6) 1559 - 1562 2018年3月16日査読有り

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Sayaka Ohrui, Naoshi Yamamoto, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase

Bioorganic and Medicinal Chemistry Letters 28(4) 774 - 777 2018年2月15日査読有り

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(17) 4176 - 4179 2017年9月査読有り

Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon

Noriki Kutsumura, Ryuichiro Ohshita, Jumpei Horiuchi, Kotaro Tateno, Naoshi Yamamoto, Tsuyoshi Saitoh, Yasuyuki Nagumo, Hidetoshi Kawai, Hiroshi Nagase

TETRAHEDRON 73(34) 5214 - 5219 2017年8月査読有り

Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.

Kutsumura N, Koyama Y, Nagumo Y, Nakajima R, Miyata Y, Yamamoto N, Saitoh T, Yoshida N, Iwata S, Nagase H

Bioorganic & medicinal chemistry 25(16) 4375 - 4383 2017年8月査読有り

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Hiroshi Nagase, Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Daisuke Kuroda, Yurie Watanabe, Hiroaki Gouda, Masashi Yanagisawa

JOURNAL OF MEDICINAL CHEMISTRY 60(3) 1018 - 1040 2017年2月査読有り

The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata, Masanobu Kano

NEURON 91(5) 1097 - 1109 2016年9月査読有り

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain

Ryo Nakajima, Naoshi Yamamoto, Shigeto Hirayama, Takashi Iwai, Akiyoshi Saitoh, Yasuyuki Nagumo, Hideaki Fujii, Hiroshi Nagase

BIOORGANIC & MEDICINAL CHEMISTRY 23(19) 6271 - 6279 2015年10月査読有り

Rewiring of Afferent Fibers in the Somatosensory Thalamus of Mice Caused by Peripheral Sensory Nerve Transection

Yuichi Takeuchi, Miwako Yamasaki, Yasuyuki Nagumo, Keiji Imoto, Masahiko Watanabe, Mariko Miyata

JOURNAL OF NEUROSCIENCE 32(20) 6917 - 6930 2012年5月査読有り

Synapse- and subtype-specific modulation of synaptic transmission by nicotinic acetylcholine receptors in the ventrobasal thalamus

Yasuyuki Nagumo, Yuichi Takeuchi, Keiji Imoto, Mariko Miyata

NEUROSCIENCE RESEARCH 69(3) 203 - 213 2011年3月査読有り

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