Yoshinobu Nakamura - My portal - researchmap

Profile Information

Affiliation: Faculty of Pharmacy, Department of Pharmacy, Takasaki University of Health and Welfare

Degree: 博士（創薬科学）(Mar, 2019, 金沢大学)

ORCID ID: https://orcid.org/0000-0003-3658-1663
J-GLOBAL ID: 202001009803667954
researchmap Member ID: R000002678

External link: https://www.molecularkinetics.org

Research Areas

2

Research History

3

Apr, 2024 - Present

Lecturer, Faculty of Pharmacy Department of Pharmacy, Takasaki University of Health and Welfare
Apr, 2020 - Mar, 2024

Assistant professor, Faculty of Pharmacy Department of Pharmacy, Takasaki University of Health and Welfare
Apr, 2019 - Mar, 2020

Postdoctoral researcher, Department of Pharmacy, Shiga University of Medical Science Hospital

Education

3

Apr, 2016 - Mar, 2019

Faculty of Pharmaceutical Sciences, Institute of Medical and Health Sciences, Kanazawa University
Apr, 2014 - Mar, 2016

Faculty of Pharmaceutical Sciences, Institute of Medical and Health Sciences, Kanazawa University
Apr, 2010 - Mar, 2014

Kanazawa University

Professional Memberships

4

Dec, 2021 - Present

日本生理学会
Apr, 2017 - Present

日本脂質生化学会
Dec, 2015 - Present

日本薬学会
Jun, 2014 - Present

日本薬物動態学会

Committee Memberships

1

May, 2021 - Present

Frontiers in Pharmacology, Review Editor

Awards

4

Oct, 2020

優秀口頭発表賞, 第15回トランスポーター研究会年会

中村吉伸
Mar, 2019

学長賞, 金沢大学

中村吉伸
Oct, 2017

優秀発表賞, 第39回生体膜と薬物の相互作用シンポジウム

中村吉伸
Mar, 2016

優秀発表賞 (口頭の部), 日本薬学会第136年会

中村吉伸

Papers

14

Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10

Yoshinobu Nakamura, Masa-aki Ito, Yukino Hoshino, Isao Matsuoka, Toshiaki Okada, Yasunobu Okada, Takeo Nakanishi

American Journal of Physiology-Cell Physiology, Feb 19, 2024 Peer-reviewedLead author
An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD

Takeo Nakanishi, Yuki Kawasaki, Yoshinobu Nakamura, Yuuki Kimura, Kotone Kawamura, Melody N. Shumba, Noriaki Shimokawa

Experimental Cell Research, 431(1) 113740-113740, Oct, 2023 Peer-reviewed
N-glycosylation modifies prostaglandin E2 uptake by reducing cell surface expression of SLCO2A1

Yoshinobu Nakamura, Chisato Aizawa, Hinako Kawata, Takeo Nakanishi

Prostaglandins & Other Lipid Mediators, 165 106714-106714, Apr, 2023 Peer-reviewedLead author
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1

Yoshinobu Nakamura, Hina Kozakai, Tsubura Nishio, Kazuki Yoshida, Takeo Nakanishi

Drug Metabolism and Pharmacokinetics, 44 100452-100452, Jun, 2022 Peer-reviewedLead author
Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth

Tokuji Tsuji, Shin-ya Morita, Yoshinobu Nakamura, Yoshito Ikeda, Taiho Kambe, Tomohiro Terada

Scientific Reports, 11(1), Jan, 2021 Peer-reviewed
Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action

Takeo Nakanishi, Yoshinobu Nakamura, Junji Umeno

Pharmacology & Therapeutics, 223 107803-107803, Jan, 2021 Peer-reviewed
Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation

Takeo Nakanishi, Shiori Sakiyama, Hiroki Takashima, Ryokichi Honda, Melody N. Shumba, Yoshinobu Nakamura, Kazuo Kasahara, Ikumi Tamai

Toxicology and Applied Pharmacology, 115201-115201, Aug, 2020 Peer-reviewed
Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene.

Scientific reports, Mar 17, 2020 Peer-reviewed
Quantification of Prostaglandin E2 Concentration in Interstitial Fluid from the Hypothalamic Region of Free-moving Mice

BIO-PROTOCOL, Aug 5, 2019 Peer-reviewedLead author
Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System

Biological & pharmaceutical bulletin, Sep 1, 2018 Peer-reviewedInvitedLead author
Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever

The Journal of neuroscience : the official journal of the Society for Neuroscience, May 21, 2018 Peer-reviewedLead author
Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1.

Journal of pharmaceutical sciences, May 4, 2017 Peer-reviewed
Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.

Experimental cell research, Feb 2, 2016 Peer-reviewed
OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.

Biochemical pharmacology, Oct 22, 2015 Peer-reviewed

Misc.

2

POTENTIAL OF PROSTAGLANDIN TRANSPORTER OATP2A1/SLCO2A1 AS A TARGET OF NOVEL ANTI-INFLAMMATORY DRUG

Hiroaki Shimada, Takeo Nakanishi, Yoshinobu Nakamura, Masahiro Iwaki, Ikumi Tamai

DRUG METABOLISM AND PHARMACOKINETICS, 32(1) S102-S103, Jan, 2017 Peer-reviewed
RELEVANCE OF PROSTAGLANDIN TRANSPORTER (PGT) TO PGE(2) SECRETION FROM MACROPHAGES IN RESPONSE TO INFLAMMATORY STIMULATION

Nakamura Yoshinobu, Nakanishi Takeo, Shimada Hiroaki, Tamai Ikumi

DRUG METABOLISM REVIEWS, 47 288, Nov 20, 2015 Peer-reviewed

Presentations

26

Annexin A2およびS100A10がSLCO2A1のプロスタグランジンE2輸送活性に及ぼす影響

中村吉伸, 伊藤政明, 星野雪乃, 松岡功, 岡田俊昭, 岡田泰伸, 中西猛夫

日本薬学会第144年会, Mar 30, 2024
プロスタグランジン輸送体SLCO2A1のMaxi-Clチャネル活性発現機構

中村吉伸

第1回 Transformative Life Science Meeting, Mar 16, 2024
Do hypotonicity and accessory proteins required for Maxi-Cl channel affect SLCO2A1-mediated prostaglandin E2 transport activity?

Yoshinobu Nakamura, Masa-aki Ito, Yukino Hoshino, Isao Matsuoka, Takeo Nakanishi

2023 ICCP450/JSSX, Sep 26, 2023
Maxi-Clアクセサリータンパク質ANXA2およびS100A10がSLCO2A1のプロスタグランジンE2輸送活性に及ぼす影響

中村吉伸, 伊藤政明, 星野雪乃, 松岡功, 中西, 猛夫

第17回トランスポーター研究会年会, May 27, 2023
輸送体とチャネルのデュアル機能を備えた膜タンパク質がもたらす生理的意義

中村吉伸

Keio Pharmaceutics Research Forum 2023 Frontiers in Biopharmaceutics, 2023
Role of N-glycosylation in the function and subcellular localization of prostaglandin transporter SLCO2A1

Yoshinobu Nakamura, Chisato Aizawa, Hinako Kawata, Takeo Nakanishi

Nov 10, 2022
N型糖鎖修飾によるプロスタグランジン膜輸送体SLCO2A1の細胞内局在変動

中村吉伸, 相澤千里, 川田日向子, 中西猛夫

第16回トランスポーター研究会年会, Jul 30, 2022
低張性刺激がSLCO2A1のプロスタグランジンE2輸送能に及ぼす影響

中村吉伸, 伊藤政明, 岡田俊昭, 岡田泰伸, 松岡功, 中西, 猛夫

日本薬学会第142年会, Mar 27, 2022
プロスタグランジン膜輸送体SLCO2A1におけるN型糖鎖の役割

川田日向子, 中村吉伸, 相澤千里, 中西, 猛夫

日本薬学会第142年会, Mar 26, 2022
フェノールスルホンフタレインを用いたプロスタグランジン膜輸送体SLCO2A1機能評価

西尾円来, 中村吉伸, 小酒井陽奈, 吉田一貴, 中西, 猛夫

日本薬学会第142年会, Mar 26, 2022
低張性刺激がSLCO2A1のプロスタグランジンE2輸送及びMaxi-Clチャネル活性に及ぼす影響

中村吉伸, 伊藤政明, 岡田俊昭, 岡田泰伸, 松岡功, 中西, 猛夫

第99回日本生理学会大会, Mar 16, 2022
Phenol red as a novel substrate of prostaglandin transporter SLCO2A1

Nov 18, 2021
プロスタグランジン膜輸送体SLCO2A1による海馬PGD2濃度調節

中村吉伸, 中西猛夫

日本薬学会第141年会, Mar 27, 2021
Brain region-specific regulation of prostaglandin D2 distribution by SLCO2A1

Yoshinobu Nakamura, Takeo Nakanishi

35th JSSX, Dec 1, 2020
プロスタグランジン膜輸送体SLCO2A1による中枢神経系におけるPGD2濃度調節機構

中村吉伸, 坂口貴俊, 中西猛夫

第15回トランスポーター研究会年会, Oct 13, 2020
The role of Oatp2a1/Slco2a1 in macrophages in PGE2 disposition in the hypothalamus during fever

Yoshinobu Nakamura, Takeo Nakanishi, Hiroaki Shimada, Ikumi Tamai

2018 International Meeting on 22nd MDO and 33rd JSSX, Oct 3, 2018
Essential contribution of prostaglandin transporter OATP2A1/SLCO2A1 to the febrile response

Yoshinobu Nakamura, Takeo Nakanishi, Kei Higuchi, Takashi Okura, Yoshiharu Deguchi, Ikumi Tamai

59th International Conference on The Bioscience of Lipids, Sep 5, 2018
プロスタグランジン輸送体OATP2A1/SLCO2A1によるマクロファージ細胞内PGE2動態調節機構

中村吉伸, 中西猛夫, 清水淳也, 坂口貴俊, 玉井郁巳

第60回日本脂質生化学会, May 31, 2018
内毒素による脳内プロスタグランジンE2動態変化におけるOATP2A1の役割

中村吉伸, 中西猛夫, 樋口慧, 黄倉崇, 出口芳春, 玉井郁巳

第39回生体膜と薬物の相互作用シンポジウム, Oct 26, 2017
プロスタグランジン輸送体OATP2A1/SLCO2A1遺伝子欠損マウスにおける内毒素の発熱作用

中村吉伸, 中西猛夫, 清水淳也, 玉井郁巳

第59回日本脂質生化学会, Jun 15, 2017

More

Teaching Experience

6

2020 - Present

薬物動態学実習 (Takasaki University of Health and Welfare)
2020 - Present

製剤学実習 (高崎健康福祉大学)
2021 - Present

臨床系薬学実習 (Takasaki University of Health and Welfare)
2022 - Present

薬学総合演習III (Takasaki University of Health and Welfare)
2023 - Present

情報リテラシーIV (Takasaki University of Health and Welfare)
2024 - Present

テーラーメイド医療学 (高崎健康福祉大学)

Research Projects

4

Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (International Collaborative Research), Japan Society for the Promotion of Science, Sep, 2023 - Mar, 2027
SLCOトランスポーターをコアとするチャネル活性発現機構の解明

若手研究, 若手研究, 日本学術振興会科学研究費助成事業, Apr, 2022 - Mar, 2025

中村吉伸
Elucidation of the mechanisms of subcellular localization of the prostaglandin transporter

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, Sep, 2020 - Mar, 2022

Nakamura Yoshinobu
膜リン脂質非対称分布評価に基づくエキソソームの機能解明

平成31年度学長裁量経費研究助成 (若手萌芽研究), 滋賀医科大学, Apr, 2019 - Mar, 2020

中村吉伸