Sep, 2020 - Mar, 2022
Elucidation of the mechanisms of subcellular localization of the prostaglandin transporter
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up Grant-in-Aid for Research Activity start-up
- Grant number
- 20K22719
- Japan Grant Number (JGN)
- JP20K22719
- Grant amount
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- (Total)
- 2,860,000 Japanese Yen
- (Direct funding)
- 2,200,000 Japanese Yen
- (Indirect funding)
- 660,000 Japanese Yen
Prostaglandin (PG) transporter SLCO2A1 plays an important role in the regulation of PG actions. Its loss of function is responsible for two refractory diseases, pachydermoperiostosis (PDP) and chronic enteropathy associated with SLCO2A1 (CEAS). We found that SLCO2A1 localizes differently at the plasma membrane and/or intracellular vesicles depending on the cell types. This differential localization modulates PG actions in opposite directions, "attenuated" and "enhanced," however the mechanisms of subcellular localization of SLCO2A1 remain unclear. In this study, we found that N-glycosylation, a post-translational modification, is one of the localization regulators that modulates the plasma membrane expression levels of SLCO2A1.
- Link information
- ID information
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- Grant number : 20K22719
- Japan Grant Number (JGN) : JP20K22719