論文

査読有り
1998年4月

Reduction of a model for an Onchidium pacemaker neuron

BIOLOGICAL CYBERNETICS
  • Y Maeda
  • ,
  • K Pakdaman
  • ,
  • T Nomura
  • ,
  • S Doi
  • ,
  • S Sato

78
4
開始ページ
265
終了ページ
276
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s004220050432
出版者・発行元
SPRINGER

The eight-variable model for the giant neuron localized in the esophageal ganglia of the marine pulmonate mollusk Onchidium verruculatum is reduced to four-and-three-dimensional systems by regrouping variables with similar time scales. These reduced models replicate the complex behavior including beating, periodic bursting and aperiodic bursting displayed by the original full model when the parameter I(ext) representing the intensity of the constant DC current stimulation is varied across a wide range. The complex behavior of the full model arises from the interaction of fast and slow dynamics, and depends on the time scale C(s) of the slow dynamics. The four-variable reduced model is constructed independently from the parameter C(s) so that it reproduces the two-dimensional bifurcation structure of the full model for the two parameters I(ext) and C(s). The three-variable reduced model is derived for a specific value of C(s). The parameters of this model are tuned so that its one-parameter bifurcation diagram for I(ext) closely matches that of the full model. Correspondence between bifurcation structures ensures that both reduced models reproduce the various discharge patterns of the full model. Similarity between the full and reduced models is also confirmed by comparing mean firing frequencies and membrane potential waveforms in various regimes. The reduction exposes the factors essential for reproducing the dynamics of the full model; indeed, it shows that the eight variables representing the membrane potential and seven gating variables of six ionic currents in the full model account, in fact, for three basic processes responsible for excitability, post-discharge refractoriness and slow membrane modulation.

リンク情報
DOI
https://doi.org/10.1007/s004220050432
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000074091100003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s004220050432
  • ISSN : 0340-1200
  • Web of Science ID : WOS:000074091100003

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